Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kethireddy V.V. Ananthalakshmi"'
Publikováno v:
Developmental & Comparative Immunology. 74:200-208
We recently demonstrated Ang 1–7 reduced inflammation in the dextran sulfate sodium (DSS) colitis model. In this study we examined the effect of Ang 1–7 on modulation of plasma levels of selected cytokines and chemokines and immune cell effector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0612b8bbd090e33610502e82b6099981
https://doi.org/10.1016/j.dci.2017.05.005
https://doi.org/10.1016/j.dci.2017.05.005
Autor:
Mohamed G. Qaddoumi, Kethireddy V.V. Ananthalakshmi, Ivan O. Edafiogho, Oludotun A. Phillips, Samuel B. Kombian
Publikováno v:
European Journal of Medicinal Chemistry. 76:20-30
Due to the excellent anticonvulsant activity of previously synthesized halogenated enaminones, more disubstituted analogs were synthesized and evaluated in vitro. The new enaminones either had no effect, depressed, or enhanced population spike (PS) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3014e1e8818b513ef925875180530b
https://doi.org/10.1016/j.ejmech.2014.02.002
https://doi.org/10.1016/j.ejmech.2014.02.002
Anti-Inflammatory Properties of the Enaminone E121 in the Dextran Sulfate Sodium (DSS) Colitis Model
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 12, p e0168567 (2016)
PLoS ONE, Vol 11, Iss 12, p e0168567 (2016)
Background Enaminones are synthetic compounds with an established role in the prevention of various forms of seizures. Recent evidence suggests potent anti-tussive, bronchodilation and anti-inflammatory properties. Pre-treatment with particularly E12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0671a54ad52cad9df96c0a7110bcec99
http://europepmc.org/articles/PMC5173236
http://europepmc.org/articles/PMC5173236
Publikováno v:
Medical Principles and Practice. 17:365-372
Objectives: We tested if E139, an anticonvulsant enaminone, interacts with norepinephrine (NE) to suppress population responses and chemically induced in vitro seizures in the rat hippocampus. Materials and Methods: Evoked field population spikes (PS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd117caeebbd85ae2857e10e238e3ad7
https://doi.org/10.1159/000141499
https://doi.org/10.1159/000141499
Autor:
Noha N. Salama, Natalie D. Eddington, Ivan O. Edafiogho, Kethireddy V.V. Ananthalakshmi, Samuel B. Kombian, Patrice L. Jackson, K. R. Scott, Mariano S. Alexander, Tiffany L. Wilson, Clive D. Hanson
Publikováno v:
Journal of Pharmaceutical Sciences. 96:2509-2531
Enaminones, enamines of beta-dicarbonyl compounds, have been known for many years. Their early use has been relegated to serving as synthetic intermediates in organic synthesis and of late, in pharmaceutical development. Recently, the therapeutic pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23838db88d4d3899c10282d6f25ffe1d
https://doi.org/10.1002/jps.20967
https://doi.org/10.1002/jps.20967
Publikováno v:
Epilepsy Research. 76:85-92
Some enaminones are reported to have in vivo anticonvulsant activity. We asked if methyl 4-(4'-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate (E139), one of such enaminones produced in vitro effects that may underlie or explain these in vivo an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5787f19d47417ace3872b2799aafc2
https://doi.org/10.1016/j.eplepsyres.2007.07.001
https://doi.org/10.1016/j.eplepsyres.2007.07.001
Autor:
Subramanian S. Parvathy, Samuel B. Kombian, Kethireddy V.V. Ananthalakshmi, Wandikayi C. Matowe
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 84:203-211
We recently reported that the activation of cholecystokinin-2 receptors depress evoked excitatory postsynaptic currents (EPSCs) in nucleus accumbens (NAc) indirectly through γ-aminobutyric acid (GABA) acting on γ-aminobutyric acid-B (GABAB) recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402e33d563fb1d4e69cb15d7a4ed2c63
https://doi.org/10.1139/y05-119
https://doi.org/10.1139/y05-119
Publikováno v:
Neuroscience. 141:345-356
Enaminones are a novel group of compounds some of which possess anticonvulsant activity in in vivo animal models of seizures. We recently reported that some enaminones, including methyl 4-(4'-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate, depr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20924faa7ad90105d4dfb9223a314d2d
https://doi.org/10.1016/j.neuroscience.2006.03.021
https://doi.org/10.1016/j.neuroscience.2006.03.021
Publikováno v:
British Journal of Pharmacology. 145:945-953
Enaminones are a novel group of compounds that have been shown to possess anticonvulsant activity in in vivo animal models of seizures. The cellular mechanism by which these compounds produce their anticonvulsant effects is not yet known. This study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcbbd1877d4937dfe90ba24a546e013e
https://doi.org/10.1038/sj.bjp.0706250
https://doi.org/10.1038/sj.bjp.0706250
Autor:
Kethireddy V.V. Ananthalakshmi, Subramanian S. Parvathy, Samuel B. Kombian, Wandikayi C. Matowe
Publikováno v:
Journal of Neuroscience Research. 79:412-420
We recently reported that cholecystokinin (CCK) excited nucleus accumbens (NAc) cells and depressed excitatory synaptic transmission indirectly through gamma-aminobutyric acid (GABA), acting on presynaptic GABAB receptors (Kombian et al. [2004] J. Ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c97ead141e0ab23d1d13e97e5cf804f
https://doi.org/10.1002/jnr.20349
https://doi.org/10.1002/jnr.20349