Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology

Autor: Andreia Gomes-Duarte, Morten T. Venø, Marina de Wit, Ketharini Senthilkumar, Mark H. Broekhoven, Joëlle van den Herik, Fleur R. Heeres, Daniëlle van Rossum, Mateja Rybiczka-Tesulov, Ivano Legnini, Peter C. van Rijen, Pieter van Eijsden, Peter H. Gosselaar, Nikolaus Rajewsky, Jørgen Kjems, Vamshidhar R. Vangoor, R. Jeroen Pasterkamp

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Mesial temporal lobe epilepsy (mTLE) is a chronic disease characterized by recurrent seizures that originate in the temporal lobes of the brain. Anti-epileptic drugs (AEDs) are the standard treatment for managing seizures in mTLE patients, but are fr

Externí odkaz: https://doaj.org/article/410e483a1b334ae3bc86f6ea487598f0

Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment

Autor: James D. Mills, Anand M. Iyer, Jackelien van Scheppingen, Anika Bongaarts, Jasper J. Anink, Bart Janssen, Till S. Zimmer, Wim G. Spliet, Peter C. van Rijen, Floor E. Jansen, Martha Feucht, Johannes A. Hainfellner, Pavel Krsek, Josef Zamecnik, Katarzyna Kotulska, Sergiusz Jozwiak, Anna Jansen, Lieven Lagae, Paolo Curatolo, David J. Kwiatkowski, R. Jeroen Pasterkamp, Ketharini Senthilkumar, Lars von Oerthel, Marco F. Hoekman, Jan A. Gorter, Peter B. Crino, Angelika Mühlebner, Brendon P. Scicluna, Eleonora Aronica

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)

Abstract Tuberous Sclerosis Complex (TSC) is a rare genetic disorder that results from a mutation in the TSC1 or TSC2 genes leading to constitutive activation of the mechanistic target of rapamycin complex 1 (mTORC1). TSC is associated with autism, i

Externí odkaz: https://doaj.org/article/201057c7a40346ccbc3ef966170890fc

Diagnostic and prognostic factors in patients with prostate cancer

Autor: Antonella Cardone, Nicolas Mottet, Lisa Moris, Michael Lardas, Anna Haire, Francesco Barletta, Simone Scuderi, Eleni Vradi, Giorgio Gandaglia, Steven MacLennan, Bahman Farahmand, Sara J Maclennan, Zsuzsanna Devecseri, Alex Asiimwe, Laurence Collette, Anders Bjartell, James Ndow, James N'Dow, Karin Plass, Maria Ribal, Thomas Van den Broeck, Peter-Paul Willemse, Karl H Pang, Riccardo Campi, Isabella Greco, Mauro Gacci, Sergio Serni, Susan Evans-Axelsson, Ragnar Lonnerbro, Daniele Crosti, Massimiliano Meoni, Roberto Garzonio, Chris Bangma, Monique Roobol, Sebastiaan Remmers, Derya Tilki, Teemu Murtola, Tapio Visakorpi, Kirsi Talala, Teuvo Tammela, Aino Siltari, Stephane Lejeune, Femke van Diggelen, Georgia Taxiarchopoulou, Ketharini Senthilkumar, Stefanie Schütte, Sophie Byrne, Luz Fialho, Paulina Gono, Monica De Vetter, Klevisa Ceke, Bertrand De Meulder, Charles Auffray, Irina-Afrodita Balaur, Nesrine Taibi, Shaun Power, Nazanin Zounemat Kermani, Kees van Bochove, Marinel Cavelaars, Maxim Moinat, Emma Voss, Chiara Bernini, Denis Horgan, Louise Fullwood, Marc Holtorf, Doron Lancet, Gabi Bernstein, Imran Omar, Sara MacLennan, Jemma Healey, Johannes Huber, Manfred Wirth, Michael Froehner, Beate Brenner, Angelika Borkowetz, Christian Thomas, Friedemann Horn, Kristin Reiche, Markus Kreuz, Andreas Josefsson, Delila Gasi Tandefelt, Jonas Hugosson, Jack Schalken, Henkjan Huisman, Thomas Hofmarcher, Emelie Andersson, Adam Fridhammar, Frank Verholen, John-Edward Butler-Ransohoff, Todd Williamson, Kumari Chandrawansa, Dorothy Dlamini, Reg Waldeck, Megan Molnar, Amanda Bruno, Ronald Herrera, Ekaterina Nevedomskaya, Niculae Constantinovici, Carl Steinbeißer, Sini Thomas, Monika Maass, Patrizia Torremante, Marc Dietrich Voss, Guido Cuperus, Chad Dau Kishore, Papineni Jing, Wang-silvanto Steve, Hass Robert, Snijder Verena, Doyé Xuewei, Wang Andy Garnham, Mark Lambrecht, Russ Wolfinger, Stijn Rogiers, Angela Servan, Florence Lefresne, Joaquin Casariego, Mohamed Samir, Joe Lawson, Katie Pascoe, Bertrand Jaton, Daniel Bakkard, Heidi Turunen, Olavi Kilkku, Pasi Pohjanjousi, Olli Voima, Liina Nevalaita, Sonia Araujo, Elaine Longden-Chapman, Gordon McVie, Danny Burke, Paul Agapow, Sahra Derkits, Muriel Licour, Charles McCrea, Sarah Payne, Alan Yong, Flavia Lujan, Billy Franks, Michael Bussmann, Inken Köhle

Publikováno v: BMJ Open, 11(2):e040531. BMJ Publishing Group
BMJ Open, Vol 11, Iss 2 (2021)
BMJ Open, 11, 2
BMJ Open
BMJ Open, 11

IntroductionAs part of the PIONEER (Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe) Consortium, we will explore which diagnostic and prognostic factors (DPFs) are currently being researched to previously d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6072f1e1513abfbb49b535bd2b3408b
https://pure.eur.nl/en/publications/be3fa593-e34d-41f8-9787-1617757d790c

Small molecule inhibition of PIKFYVE kinase rescues gain- and loss-of-function C9ORF72 ALS/FTD disease processes in vivo

Autor: Shaoyu Lin, Yingfei Wang, Kim D, Justin K. Ichida, Ketharini Senthilkumar, Koutsodendris N, Yingxiao Shi, Ya-tang Li, Vamshidhar R. Vangoor, Wen-Hsuan Chang, Morgan Chateau, Paula M. Cannon, Kim A. Staats, Pasterkamp Rj, Carina Seah, Gray Ka, Berislav V. Zlokovic, Sahimi A

The most common known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a hexanucleotide repeat expansion (HRE) in C9ORF72 that contributes to neurodegeneration by both loss-of-function (decreased C9ORF72 protein level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6988c45830ebe2bdcb6bac457afdae76

Antagonizing Increased

Autor: Vamshidhar R, Vangoor, Cristina R, Reschke, Ketharini, Senthilkumar, Lieke L, van de Haar, Marina, de Wit, Giuliano, Giuliani, Mark H, Broekhoven, Gareth, Morris, Tobias, Engel, Gary P, Brennan, Ronan M, Conroy, Peter C, van Rijen, Peter H, Gosselaar, Stephanie, Schorge, Roel Q J, Schaapveld, David C, Henshall, Pierre N E, De Graan, R Jeroen, Pasterkamp

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(26)

Mesial temporal lobe epilepsy (mTLE) is a chronic neurological disease characterized by recurrent seizures. The antiepileptic drugs currently available to treat mTLE are ineffective in one-third of patients and lack disease-modifying effects. miRNAs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04e536ed66bd35d9a24aacd44e0c67dc
https://pubmed.ncbi.nlm.nih.gov/31015341