What monozygotic twins discordant for phenotype illustrate about mechanisms influencing genetic forms of neurodegeneration.

Autor: Ketelaar, ME, Hofstra, RMW, Hayden, MR

Publikováno v: Clinical Genetics; Apr2012, Vol. 81 Issue 4, p325-333, 9p

IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status.

Autor: Saikumar Jayalatha AK; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Department of Pathology and Medical Biology, Groningen, The Netherlands.; Shared first authorship., Ketelaar ME; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Department of Pathology and Medical Biology, Groningen, The Netherlands.; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, The Netherlands.; Shared first authorship., Hesse L; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Department of Pathology and Medical Biology, Groningen, The Netherlands.; Shared first authorship., Badi YE; National Heart and Lung Institute, Department of Respiratory Cell and Molecular Biology, Imperial College London, London, UK., Zounemat-Kermani N; National Heart and Lung Institute, Department of Respiratory Cell and Molecular Biology, Imperial College London, London, UK., Brouwer S; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Department of Pathology and Medical Biology, Groningen, The Netherlands., Dijk NF; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, The Netherlands., van den Berge M; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Department of Pulmonary Diseases, Groningen, The Netherlands., Guryev V; University of Groningen, GRIAC Research Institute and European Research Institute for the Biology of Ageing, Groningen, The Netherlands., Sayers I; Centre for Respiratory Research, NIHR Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Vonk JE; University of Groningen, University Medical Center Groningen, GRIAC Research institute, Department of Epidemiology, Groningen, The Netherlands., Adcock IM; National Heart and Lung Institute, Department of Respiratory Cell and Molecular Biology, Imperial College London, London, UK., Koppelman GH; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, The Netherlands., Nawijn MC; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Department of Pathology and Medical Biology, Groningen, The Netherlands m.c.nawijn@umcg.nl.

Publikováno v: The European respiratory journal [Eur Respir J] 2024 Jun 20; Vol. 63 (6). Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024).

The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention.

Autor: Saikumar Jayalatha AK; University of Groningen, University Medical Centre Groningen, Department of Pathology and Medical Biology, Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Groningen, the Netherlands; University of Groningen University Medical Centre Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands., Hesse L; University of Groningen, University Medical Centre Groningen, Department of Pathology and Medical Biology, Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Groningen, the Netherlands; University of Groningen University Medical Centre Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands., Ketelaar ME; University of Groningen, University Medical Centre Groningen, Department of Pathology and Medical Biology, Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Groningen, the Netherlands; University of Groningen University Medical Centre Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands; University of Groningen University Medical Centre Groningen, Beatrix Children's Hospital, Department of Paediatric Pulmonology and Paediatric Allergology, Groningen, the Netherlands., Koppelman GH; University of Groningen University Medical Centre Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands; University of Groningen University Medical Centre Groningen, Beatrix Children's Hospital, Department of Paediatric Pulmonology and Paediatric Allergology, Groningen, the Netherlands., Nawijn MC; University of Groningen, University Medical Centre Groningen, Department of Pathology and Medical Biology, Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Groningen, the Netherlands; University of Groningen University Medical Centre Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands. Electronic address: m.c.nawijn@umcg.nl.

Publikováno v: Pharmacology & therapeutics [Pharmacol Ther] 2021 Sep; Vol. 225, pp. 107847. Date of Electronic Publication: 2021 Apr 02.

Phenotypic and functional translation of IL33 genetics in asthma.

Autor: Ketelaar ME; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Division of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom. Electronic address: m.e.ketelaar@umcg.nl., Portelli MA; Division of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Dijk FN; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Shrine N; Department of Health Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research Leicester Respiratory Biomedical Research Centre, Leicester, United Kingdom., Faiz A; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Vermeulen CJ; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Xu CJ; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; CiiM & TWINCORE, Helmholtz-Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Hankinson J; Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom., Bhaker S; Division of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Henry AP; Division of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Billington CK; Division of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Shaw DE; Division of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Johnson SR; Division of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Benest AV; Division of Cancer and Stem Cells, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, and COMPARE University of Birmingham and University of Nottingham, Nottingham, United Kingdom., Pang V; Division of Cancer and Stem Cells, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, and COMPARE University of Birmingham and University of Nottingham, Nottingham, United Kingdom., Bates DO; Division of Cancer and Stem Cells, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, and COMPARE University of Birmingham and University of Nottingham, Nottingham, United Kingdom., Pogson ZEK; Department of Respiratory Medicine, Lincoln County Hospital, Lincoln, United Kingdom; Division of Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom., Fogarty A; Division of Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom., McKeever TM; Division of Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom., Singapuri A; Institute for Lung Health, Department of Respiratory Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom., Heaney LG; Centre for Infection and Immunity, Queen's University of Belfast, Belfast, United Kingdom., Mansur AH; Respiratory Medicine, Birmingham Heartlands Hospital and University of Birmingham, Birmingham, United Kingdom., Chaudhuri R; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Thomson NC; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Holloway JW; Human Development and Health, Faculty of Medicine and National Institute of Health Biomedical Research Centre, University of Southampton, Southampton, United Kingdom; Clinical and Experimental Sciences, Faculty of Medicine and National Institute of Health Biomedical Research Centre, University of Southampton, Southampton, United Kingdom., Lockett GA; Human Development and Health, Faculty of Medicine and National Institute of Health Biomedical Research Centre, University of Southampton, Southampton, United Kingdom; Clinical and Experimental Sciences, Faculty of Medicine and National Institute of Health Biomedical Research Centre, University of Southampton, Southampton, United Kingdom., Howarth PH; Human Development and Health, Faculty of Medicine and National Institute of Health Biomedical Research Centre, University of Southampton, Southampton, United Kingdom; Clinical and Experimental Sciences, Faculty of Medicine and National Institute of Health Biomedical Research Centre, University of Southampton, Southampton, United Kingdom., Niven R; Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom., Simpson A; Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom., Tobin MD; Department of Health Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research Leicester Respiratory Biomedical Research Centre, Leicester, United Kingdom., Hall IP; Division of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Wain LV; Department of Health Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research Leicester Respiratory Biomedical Research Centre, Leicester, United Kingdom., Blakey JD; Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Australia., Brightling CE; National Institute for Health Research Leicester Respiratory Biomedical Research Centre, Leicester, United Kingdom; Institute for Lung Health, Department of Respiratory Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom., Obeidat M; The Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada., Sin DD; The Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Nickle DC; Department of Genetics and Pharmacogenomics, Merck Research Laboratories, Boston, Mass., Bossé Y; Department of Molecular Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec City, Quebec, Canada., Vonk JM; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., van den Berge M; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Division of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Koppelman GH; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Sayers I; Division of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Nawijn MC; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Jan; Vol. 147 (1), pp. 144-157. Date of Electronic Publication: 2020 May 19.

Predictive value of serum sST2 in preschool wheezers for development of asthma with high FeNO.

Autor: Ketelaar ME; Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Pathology and Medical Biology, Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., van de Kant KD; Department of Pediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands., Dijk FN; Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Klaassen EM; Department of General Practice, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands., Grotenboer NS; Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Pathology and Medical Biology, Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Nawijn MC; Department of Pathology and Medical Biology, Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Dompeling E; Department of Pediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands., Koppelman GH; Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Publikováno v: Allergy [Allergy] 2017 Nov; Vol. 72 (11), pp. 1811-1815. Date of Electronic Publication: 2017 May 23.