Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Ketan J Patel"'
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36970 (2012)
The many proteins that function in the Fanconi anaemia (FA) monoubiquitylation pathway initiate replicative DNA crosslink repair. However, it is not clear whether individual FA genes participate in DNA repair pathways other than homologous recombinat
Externí odkaz:
https://doaj.org/article/591308a5da0d441b86b6059e5a89f409
Publikováno v:
PLoS Genetics, Vol 5, Iss 9, p e1000645 (2009)
Organisms like Dictyostelium discoideum, often referred to as DNA damage "extremophiles", can survive exposure to extremely high doses of radiation and DNA crosslinking agents. These agents form highly toxic DNA crosslinks that cause extensive DNA da
Externí odkaz:
https://doaj.org/article/14be99851ca94e03a5567e9882faed56
Autor:
Johannes Meiser, Anne Schuster, Matthias Pietzke, Johan Vande Voorde, Dimitris Athineos, Kristell Oizel, Guillermo Burgos-Barragan, Niek Wit, Sandeep Dhayade, Jennifer P. Morton, Emmanuel Dornier, David Sumpton, Gillian M. Mackay, Karen Blyth, Ketan J. Patel, Simone P. Niclou, Alexei Vazquez
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Serine catabolism to formate supplies one-carbon units for biosynthesis. Here the authors show that formate production in murine cancers with high oxidative metabolism exceeds the biosynthetic demand and that high formate levels promotes invasion of
Externí odkaz:
https://doaj.org/article/3791b6fce2b1446482c02c147ec6dfd2
Autor:
Sally B. Morton, L. David Finger, Roxanne van der Sluijs, William D. Mulcrone, Michael Hodskinson, Christopher L. Millington, Christina Vanhinsbergh, Ketan J. Patel, Mark J. Dickman, Puck Knipscheer, Jane A. Grasby, David M. Williams
Publikováno v:
Journal of the American Chemical Society.
DNA interstrand cross-links (ICLs) prevent DNA replication and transcription and can lead to potentially lethal events, such as cancer or bone marrow failure. ICLs are typically repaired by proteins within the Fanconi Anemia (FA) pathway, although th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1b46b5a757461d1e3eaa694eafae56
https://pubmed.ncbi.nlm.nih.gov/36584283
https://pubmed.ncbi.nlm.nih.gov/36584283
Autor:
Shabih Shakeel, Christopher J. Russo, Gianluca Degliesposti, Pablo Alcón, Eeson Rajendra, J.M. Skehel, Ketan J. Patel, Sarah L. Maslen, Carol V. Robinson, Chris H. Hill, Dror S. Chorev, Francis J. O’Reilly, Juri Rappsilber, Shaoda He, Sjors H.W. Scheres, Lori A. Passmore
Publikováno v:
Shakeel, S, Rajendral, E, Alcón, P, O’Reilly, F J, Chorev, D S, Maslen, S, Degliesposti, G, Russo, C J, He, S, Hill, C H, Skehel, J M, Scheres, S H W, Patel, K J, Rappsilber, J, Robinson, C V & Passmore, L A 2019, ' Structure of the fanconi anaemia monoubiquitin ligase complex ', Nature, vol. 575, pp. 234-237 . https://doi.org/10.1038/s41586-019-1703-4
Nature
Nature
The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress1,2. Genetic inactivation of this pathway by mutation of genes encoding FA complementation group (FANC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bffaa0a6d75638ea3668a8eca98bf3
https://doi.org/10.1038/s41586-019-1703-4
https://doi.org/10.1038/s41586-019-1703-4
Autor:
Olga V. Kochenova, Justin L. Sparks, Meng Wang, Lin Deng, Johannes C. Walter, Michael R. G. Hodskinson, Daniel R. Semlow, Ravindra Amunugama, Gheorghe Chistol, Claudia A. Mimoso, Emily Low, R. Alex Wu, Ketan J. Patel, Ashley N. Kamimae-Lanning
Publikováno v:
Nature
Cells often use multiple pathways to repair the same DNA lesion, and the choice of pathway has substantial implications for the fidelity of genome maintenance. DNA interstrand crosslinks covalently link the two strands of DNA, and thereby block repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7999320f7690bda56182d186dfb54b8
https://doi.org/10.1038/s41586-019-1002-0
https://doi.org/10.1038/s41586-019-1002-0
Autor:
Gillian M. Mackay, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Ketan J. Patel, Alexei Vazquez, Matthias Pietzke, Guillermo Burgos-Barragan
Publikováno v:
Communications Chemistry, Vol 3, Iss 1, Pp 1-10 (2020)
Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways starting from the reaction of form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e943349fe88a693787d28e05f9389df8
https://www.repository.cam.ac.uk/handle/1810/317845
https://www.repository.cam.ac.uk/handle/1810/317845
Autor:
David M. Williams, Mohan Mahesh, Merlijn Witte, Ketan J. Patel, Puck Knipscheer, Koichi Sato, Jason W. Chin, Maya Petek, Koos Rooijers, Michael R. G. Hodskinson, Ashley N. Kamimae-Lanning, Jan Silhan, Jop Kind, Alice Bolner
Publikováno v:
Nature
Nature, 579(7800), 603-608. Nature Publishing Group
Cell Res
Nature, 579(7800), 603-608. Nature Publishing Group
Cell Res
Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption1. Impaired detoxification of acetaldehyde is common in the Asian population, and is associated with alcohol-related cancers1,2. Cells are protected a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f54122ce1c4a07e245de32eda5cc1b
https://europepmc.org/articles/PMC7116288/
https://europepmc.org/articles/PMC7116288/
Publikováno v:
Alcón, P, Shakeel, S, Chen, Z A, Rappsilber, J, Patel, K J & Passmore, L A 2020, ' FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair ', Nature Structural and Molecular Biology, vol. 27, no. 3, pp. 240-248 . https://doi.org/10.1038/s41594-020-0380-1
Nature structural & molecular biology
Nature structural & molecular biology
Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks. Numerous factors involved in crosslink repair have been identified, and mutations in their corresponding genes cause Fanconi anemia (FA). A key step in crosslink repai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dee59bf22e62e4f4da816000c77dee
https://www.pure.ed.ac.uk/ws/files/157669496/PMID32066963_AAM_Rappsilber.pdf
https://www.pure.ed.ac.uk/ws/files/157669496/PMID32066963_AAM_Rappsilber.pdf
Autor:
Lee Mulderrig, Naomi Park, Serena Nik-Zainal, Frederic Langevin, Juan I. Garaycoechea, Guillaume Guilbaud, Fentang Yang, Gerry P. Crossan, Ketan J. Patel, Sophie Roerink, Sandra Louzada, Michael R. Stratton
Publikováno v:
Nature. 553:171-177
Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damage initiates malignancies. Here we describe the features and mutational landscape of DNA damage caused by acetaldehyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8c4f41485eb2814ca4ed75f1c67c97
https://doi.org/10.1038/nature25154
https://doi.org/10.1038/nature25154