Výsledky vyhledávání - "Ketan Hippalgaonkar"

Indomethacin-Loaded Solid Lipid Nanoparticles for Ocular Delivery: Development, Characterization, and In Vitro Evaluation

Autor: Michael A. Repka, Soumyajit Majumdar, Goutham R. Adelli, Kanchan Hippalgaonkar, Ketan Hippalgaonkar

Publikováno v: Journal of Ocular Pharmacology and Therapeutics. 29:216-228

The goal of this study was to develop and characterize indomethacin-loaded solid lipid nanoparticles (IN-SLNs; 0.1% w/v) for ocular delivery.Various lipids, homogenization pressures/cycles, Tween 80 fraction in the mixture of surfactants (Poloxamer 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9610b6559c4437b5ae34b3cfd0b09d0
https://doi.org/10.1089/jop.2012.0069

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Evaluation of the Intravenous and Topical Routes for Ocular Delivery of Hesperidin and Hesperetin

Autor: Ketan Hippalgaonkar, Bharathi Avula, Soumyajit Majumdar, Ikhlas A. Khan, Ramesh Srirangam

Publikováno v: Journal of Ocular Pharmacology and Therapeutics. 28:618-627

The objective of this study was to determine the ocular bioavailability of hesperidin and hesperetin, especially with respect to their distribution into the posterior segment of the eye, following systemic and topical administration in rabbits.Hesper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed01e9bdabb0887a933d8129dae3404
https://doi.org/10.1089/jop.2012.0040

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Intravitreal Kinetics of Hesperidin, Hesperetin, and Hesperidin G: Effect of Dose and Physicochemical Properties

Autor: Ketan Hippalgaonkar, Ramesh Srirangam, Soumyajit Majumdar

Publikováno v: Journal of Pharmaceutical Sciences. 101:1631-1638

Hesperidin, a flavanone glycoside, and its aglycone hesperetin are potential candidates for the treatment of diabetic retinopathy and macular edema. The objective of this study was to delineate vitreal pharmacokinetics of hesperidin and hesperetin an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d3f23f187e99cf20d91d20bffbca2e
https://doi.org/10.1002/jps.23047

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Injectable Lipid Emulsions—Advancements, Opportunities and Challenges

Autor: Ketan Hippalgaonkar, Viral Kansara, Soumyajit Majumdar

Publikováno v: AAPS PharmSciTech. 11:1526-1540

Injectable lipid emulsions, for decades, have been clinically used as an energy source for hospitalized patients by providing essential fatty acids and vitamins. Recent interest in utilizing lipid emulsions for delivering lipid soluble therapeutic ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499f6898489b0f9e8873b9c6c302c6b2
https://doi.org/10.1208/s12249-010-9526-5

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Enhanced Solubility, Stability, and Transcorneal Permeability of Delta-8-Tetrahydrocannabinol in the Presence of Cyclodextrins

Autor: Soumyajit Majumdar, Ketan Hippalgaonkar, Mahmoud A. ElSohly, Michael A. Repka, Waseem Gul

The purpose of this study was to investigate the effect of cyclodextrins (CDs) on aqueous solubility, stability, and in vitro corneal permeability of delta-8-tetrahydrocannabinol (Δ(8)-THC). Phase solubility of Δ(8)-THC was studied in the presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c5b08d53f04d155cb8a8625cc35b50
https://europepmc.org/articles/PMC3134676/

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Interaction between topically and systemically coadministered P-glycoprotein substrates/inhibitors: effect on vitreal kinetics

Autor: Soumyajit Majumdar, Bharathi Avula, Ikhlas A. Khan, Ketan Hippalgaonkar, Ramesh Srirangam

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 38(10)

The objective of the present study was to investigate the effect of topically coadministered P-glycoprotein (P-gp) substrates/inhibitors on the vitreal kinetics of a systemically administered P-gp substrate. Anesthetized male rabbits were used in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068429049d2fb0978b8a927c6968bbad
https://pubmed.ncbi.nlm.nih.gov/20595378

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Vitreal Kinetics of Quinidine in Rabbits in the Presence of Topically Coadministered P-Glycoprotein Substrates/Modulators

Autor: Soumyajit Majumdar, Ketan Hippalgaonkar, Ramesh Srirangam

The purpose of this study was to investigate whether topically administered P-glycoprotein (P-gp) substrates/modulators can alter vitreal kinetics of intravitreally administered quinidine. Male New Zealand rabbits were used under anesthesia. Vitreal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991ea81d1f4597438a25528a699e77c9
https://europepmc.org/articles/PMC2712438/

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Effect of chitosan, benzalkonium chloride and ethylenediaminetetraacetic acid on permeation of acyclovir across isolated rabbit cornea

Autor: Soumyajit Majumdar, Ketan Hippalgaonkar, Michael A. Repka

Publikováno v: International journal of pharmaceutics. 348(1-2)

The overall objective of this study was to evaluate the effect of chitosan, benzalkonium chloride (BAK) and disodium ethylendiaminetetraacetic acid (EDTA), alone and in combination, on permeation of acyclovir (ACV) across excised rabbit cornea. Corne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::febd6c47368cb3b92b4a758a36789946
https://pubmed.ncbi.nlm.nih.gov/17897799

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