Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Keta Joshipura"'
Autor:
John Hardy, Jennifer Webster, Priti Nath, Jennifer Clarke, Christopher B. Heward, Peter Holmans, Alice Zhao, Mona Kaleem, Weixiong Zhang, Donald S. McCorquodale, Amanda J. Myers, Leslie Bryden, Eric M. Reiman, Diane Hu-Lince, Cindy Cuello, J. Raphael Gibbs, Victoria Zismann, Doris G. Leung, Keith D. Coon, Monika Ray, Kristen Rohrer, Dietrich A. Stephan, Lauren Marlowe, Matthew J. Huentelman, John V. Pearson, David Craig, Keta Joshipura
Publikováno v:
The American Journal of Human Genetics. 84(4):445-458
We recently surveyed the relationship between the human brain transcriptome and genome in a series of neuropathologically normal postmortem samples. We have now analyzed additional samples with a confirmed pathologic diagnosis of late-onset Alzheimer
Autor:
Rebecca F. Halperin, Rivka Ravid, Diane Hu-Lince, Amanda J. Myers, David Craig, Jennifer Webster, Mona Kaleem, John Hardy, Matthew J. Huentelman, Andreas Papassotiropoulos, Victoria Zismann, Keta Joshipura, Douglas G. Walker, John V. Pearson, Lauren Marlowe, Christopher B. Heward, Joseph M. Rogers, Thomas G. Beach, Leslie Bryden, Dietrich A. Stephan, Doris G. Leung, Eric M. Reiman, Keith D. Coon
Publikováno v:
Neurodegenerative Diseases. 5:60-64
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogen
Autor:
April McVey, Daniel T. O'Connor, Michael C. Graves, Carlayne E. Jackson, Jonathan S. Katz, Sharon E. Hesterlee, David Letizia, Travis Dunckley, Mike Hutton, Alan Pestronk, Tahseen Mozaffar, Dietrich A. Stephan, David Craig, Stanley H. Appel, Catherine Lomen-Hoerth, Kendall Jensen, Jeffrey Rosenfeld, Hiroshi Mitsumoto, Henrik Ryberg, Todd Levine, Keta Joshipura, Richard J. Barohn, Richard Crook, Rebecca F. Halperin, Robert Bowser, Ericka Simpson, Arthur Dick, Peter Bosch, Matthew J. Huentelman, John V. Pearson, Szabolcs Szelinger, Chelsea Stamper, Kuixing Zhang, Robert G. Miller, Tulio E. Bertorini
Publikováno v:
New England Journal of Medicine. 357:775-788
Approximately 90% of persons with amyotrophic lateral sclerosis (ALS) have the sporadic form, which may be caused by the interaction of multiple environmental factors and previously unknown genes.We performed a genomewide association analysis using 7
Autor:
Doris G. Leung, Keith D. Coon, Stacey Melquist, Jennifer Webster, Alice S. Zhao, Christopher B. Heward, Mona Kaleem, Walter A. Kukull, Diane Hu-Lince, John Hardy, Amanda J. Myers, Leslie Bryden, Matthew J. Huentelman, R. C. Petersen, Dietrich A. Stephan, Travis Dunckley, Eric M. Reiman, Joseph Rogers, Diego Mastroeni, Richard J. Caselli, Victoria Zismann, Andreas Papassotiropoulos, Mike Hutton, Winnie S. Liang, Andrew Grover, Lauren Marlowe, John V. Pearson, Gene E. Alexander, Rivka Ravid, Kristen Rohrer, Ri Lee H. Herbert, Thomas G. Beach, David Craig, Keta Joshipura
Publikováno v:
Neuron. 54:713-720
The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single-nucleotide polymorphisms (SNPs) to characterize and confirm other LO
Autor:
Keta Joshipura, Jennifer Webster, Victoria Zismann, Jianping Hua, Edward R. Dougherty, Dietrich A. Stephan, David Craig, Marcel Brun, Matthew J. Huentelman, Waibhav Tembe
Publikováno v:
Bioinformatics. 23:57-63
Motivation: The technology to genotype single nucleotide polymorphisms (SNPs) at extremely high densities provides for hypothesis-free genome-wide scans for common polymorphisms associated with complex disease. However, we find that some errors intro
Autor:
Brent E. Masel, Randall J. Urban, Dennis J. Zgaljardic, Kurt A. Mossberg, Jack Foreman, Keta Joshipura, Melinda Sheffield-Moore, William J. Durham
Publikováno v:
Brain injury. 28(4)
Background: Fatigue is a common and debilitating phenomenon experienced by individuals with traumatic brain injury (TBI) that can negatively influence rate and extent of functional recovery by reducing participation in brain injury rehabilitation ser
Autor:
Dietrich A. Stephan, Frank Jessen, Diane Hu-Lince, Jennifer Webster, R. C. Petersen, Joseph G. Rogers, Stacey Melquist, Jason J. Corneveaux, Eric M. Reiman, Keith D. Coon, John V. Pearson, Heike Kölsch, Winnie S. Liang, Rivka Ravid, Richard J. Caselli, Diego Mastroeni, Mike Hutton, Wendy Lee, Andreas Papassotiropoulos, Sigrid Botne Sando, Andrew Grover, Jan O. Aasly, David Craig, Daniel Bandy, Reinhard Heun, Amanda J. Myers, Keta Joshipura, Matthew J. Huentelman, Kewei Chen, Victoria Zismann, Travis Dunckley, Gene E. Alexander, Thomas G. Beach
Publikováno v:
Neurobiology of Aging, 31, 901-909. Elsevier B.V.
We recently reported evidence for an association between the individual variation in normal human episodic memory and a common variant of the KIBRA gene, KIBRA rs17070145 (T-allele). Since memory impairment is a cardinal clinical feature of Alzheimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e5322f537628b0b97e71d0bda40392
https://pure.knaw.nl/portal/en/publications/0bf7e47c-57c2-4384-8d69-0e1210224416
https://pure.knaw.nl/portal/en/publications/0bf7e47c-57c2-4384-8d69-0e1210224416
Autor:
Jennifer A, Webster, Amanda J, Myers, John V, Pearson, David W, Craig, Diane, Hu-Lince, Keith D, Coon, Victoria L, Zismann, Thomas, Beach, Doris, Leung, Leslie, Bryden, Rebecca F, Halperin, Lauren, Marlowe, Mona, Kaleem, Matthew J, Huentelman, Keta, Joshipura, Douglas, Walker, Christopher B, Heward, Rivka, Ravid, Joseph, Rogers, Andreas, Papassotiropoulos, John, Hardy, Eric M, Reiman, Dietrich A, Stephan
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62d4b63804c9f5a42a1bf3fcb35442b
https://www.zora.uzh.ch/id/eprint/49532/
https://www.zora.uzh.ch/id/eprint/49532/
Autor:
Priti Nath, Lauren Marlowe, Eric M. Reiman, Jennifer Webster, Kristen Rohrer, Victoria Zismann, Matthew J. Huentelman, John V. Pearson, Christopher B. Heward, J. Raphael Gibbs, David Craig, Dietrich A. Stephan, Keith D. Coon, John Hardy, Alice Zhao, Leslie Bryden, Keta Joshipura, Diane Hu-Lince, Mona Kaleem, Amanda J. Myers, Peter Holmans, Doris G. Leung
Publikováno v:
Nature genetics. 39(12)
It is widely assumed that genetic differences in gene expression underpin much of the difference among individuals and many of the quantitative traits of interest to geneticists. Despite this, there has been little work on genetic variability in huma
Autor:
David Craig, Keta Joshipura, Jennifer Webster, Jianping Hua, Marcel Brun, Dietrich A. Stephan, Victoria Zismann, M. J. Huentelman, Edward R. Dougherty
Publikováno v:
2006 IEEE/NLM Life Science Systems and Applications Workshop.
The fast development in high-throughput single nucleotide polymorphism (SNP) genotyping technology provides unprecedented power for genome-wide SNP association studies. However, inaccurate genotyping can lead to false association between markers and