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Targeting the Wnt pathway in zebrafish as a screening method to identify novel therapeutic compounds
Autor:
Joshua K. Robertson, Solape Bamikole, Katherine Blake, Sherise Charles, Annia Olivares, Terence J. Van Raay, Meghan Olson, Kestral Danzmann
Publikováno v:
Experimental biology and medicine (Maywood, N.J.). 239(2)
Activating mutations in the Wnt signaling pathway account for the initiation of greater than 90% of all colorectal cancers and this pathway has been implicated in numerous other diseases. Therefore, identifying small molecule inhibitors of this pathw