Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kester Jeffrey A"'
Autor:
B. K. Sorensen, Kennan C. Marsh, Eugene I. Novosad, T. J. Opgenorth, T. W. Von Geldern, Jinshyun R. Wu-Wong, William J. Chiou, Douglas B. Dixon, Jae Hwan-Soo, A. S. Tasker, Kester Jeffrey A, Steven A. Boyd, M. Winn, Lisa M. Hernández, Robert A. Mantei, Radhika Bal
Publikováno v:
Journal of Medicinal Chemistry. 39:1039-1048
We have discovered a novel class of endothelin (ET) receptor antagonists through pharmacophore analysis of the existing non-peptide ET antagonists. On the basis of this analysis, we determined that a pyrrolidine ring might replace the indian ring in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c21de90706af0ac034ce4ad4217e0c
https://doi.org/10.1021/jm9505369
https://doi.org/10.1021/jm9505369
Autor:
Kester Jeffrey A, Douglas B. Dixon, Jinshyun R. Wu-Wong, William J. Chiou, Radhika Bal, T. J. Opgenorth, T. W. Von Geldern
Publikováno v:
Journal of Medicinal Chemistry. 39:968-981
Structure-activity studies have been performed in an attempt to improve the potency of a novel series of azole-based endothelin-A (ET A ) selective antagonists. Modifications of the hydrophobic group on the terminal urea produced substantial effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a74069aa426750f7fa109d2b3b49e16
https://doi.org/10.1021/jm950592+
https://doi.org/10.1021/jm950592+
Autor:
Samuel V. Calzadilla, Douglas B. Dixon, Daniel J. Hoffman, Brian D. Dayton, Hugh N. Nellans, Lisa E. Hernandez, William J. Chiou, Jinshyun R. Wu-Wong, Kennan C. Marsh, Kester Jeffrey A, T. J. Opgenorth, T. W. Von Geldern
Publikováno v:
Journal of Medicinal Chemistry. 39:982-991
The oral absorption profile of a family of azole-based ET(A)-selective antagonists has been improved through a rational series of structural modifications which were suggested by analysis of the physicochemical parameter delta log P. Comparison of ur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fafcb821dd25a65d8813bb585b940a
https://doi.org/10.1021/jm9505932
https://doi.org/10.1021/jm9505932
Autor:
Radhika Bal, T. J. Opgenorth, T. W. Von Geldern, William J. Chiou, Kester Jeffrey A, Jinshyun R. Wu-Wong, Douglas B. Dixon
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a49826eb60ee0e3041abd7907debb37
https://doi.org/10.1002/chin.199623224
https://doi.org/10.1002/chin.199623224
Autor:
T. J. Opgenorth, T. W. Von Geldern, H.-S. Jae, Kennan C. Marsh, Steven A. Boyd, Jinshyun R. Wu-Wong, Eugene I. Novosad, B. K. Sorensen, William J. Chiou, Lisa M. Hernández, M. Winn, Douglas B. Dixon, Robert A. Mantei, Kester Jeffrey A, A. S. Tasker, Radhika Bal
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ee79cb15e11b4e4c8f929aa42454f8
https://doi.org/10.1002/chin.199627143
https://doi.org/10.1002/chin.199627143
Autor:
Douglas B. Dixon, Kester Jeffrey A, T. J. Opgenorth, T. W. Von Geldern, C. Hutchins, Jinshyun R. Wu-Wong, William J. Chiou
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7684c38aa4e0a1fc68135ddc81e573ad
https://doi.org/10.1002/chin.199623223
https://doi.org/10.1002/chin.199623223
Publikováno v:
Advances in Food and Nutrition Research ISBN: 9780123737403
There has been considerable investigation into the health benefits of calcium citrate malate (CCM) since it was first patented in the late 1980s. This chapter is a comprehensive summary of the supporting science and available evidence on the bioavail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::515b18c5f69d1fda26d01c969b4c74fc
https://doi.org/10.1016/s1043-4526(07)00006-x
https://doi.org/10.1016/s1043-4526(07)00006-x
Autor:
Ronald J. Jandacek, Thomas Joseph Wehmeier, Kester Jeffrey John, Alyce Johnson Papa, Peter Yau Tak Lin
Publikováno v:
Lipids. 34(8)
Olestra is a mixture of compounds comprising sucrose esterified with 6-8 long-chain fatty acids. It is not hydrolyzed by pancreatic lipase and as a result is not absorbed from the small intestine. Olestra in general has physical properties similar to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d84a6f6bca8323f7db795d81ae71bf
https://pubmed.ncbi.nlm.nih.gov/10529087
https://pubmed.ncbi.nlm.nih.gov/10529087
Autor:
and Douglas B. Dixon, Terry J. Opgenorth, Jinshyun R. Wu-Wong, Kester Jeffrey A, Charles W. Hutchins, Thomas W. von Geldern, William J. Chiou
Publikováno v:
Journal of medicinal chemistry. 39(4)
The pseudotetrapeptide FR-139317 is a potent and highly selective antagonist of the endothelin-A (ET(A)) receptor; however, its peptidic nature leads to poor oral absorption characteristics which make it an unlikely drug candidate. In an attempt to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8819e72c2ec0d1d33b06f130c2563e
https://pubmed.ncbi.nlm.nih.gov/8632419
https://pubmed.ncbi.nlm.nih.gov/8632419
Publikováno v:
IEEE Transactions on Power Delivery. Apr98, Vol. 13 Issue 2, p446. 7p. 4 Black and White Photographs, 5 Charts, 7 Graphs.