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Akademický článek

Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia.

Autor: van der Lee DI; Department of Hematology, and., Reijmers RM; Department of Hematology, and., Honders MW; Department of Hematology, and., Hagedoorn RS; Department of Hematology, and., de Jong RC; Department of Hematology, and., Kester MG; Department of Hematology, and., van der Steen DM; Department of Hematology, and., de Ru AH; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands., Kweekel C; Department of Hematology, and., Bijen HM; Department of Hematology, and., Jedema I; Department of Hematology, and., Veelken H; Department of Hematology, and., van Veelen PA; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands., Heemskerk MH; Department of Hematology, and., Falkenburg JHF; Department of Hematology, and., Griffioen M; Department of Hematology, and.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2019 Feb 01; Vol. 129 (2), pp. 774-785. Date of Electronic Publication: 2019 Jan 14.

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Akademický článek

Identification of non-mutated neoantigens presented by TAP-deficient tumors.

Autor: Marijt KA; Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands., Blijleven L; Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands., Verdegaal EME; Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands., Kester MG; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands., Kowalewski DJ; Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany.; German Cancer Consortium, German Cancer Research Center, Tübingen, Germany., Rammensee HG; Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany.; German Cancer Consortium, German Cancer Research Center, Tübingen, Germany., Stevanović S; Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany.; German Cancer Consortium, German Cancer Research Center, Tübingen, Germany., Heemskerk MHM; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands., van der Burg SH; Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands., van Hall T; Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands T.van_Hall@lumc.nl.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2018 Sep 03; Vol. 215 (9), pp. 2325-2337. Date of Electronic Publication: 2018 Aug 16.

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Akademický článek

TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1.

Autor: Jahn L; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Hombrink P; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Hematopoiesis, Sanquin Research, Amsterdam, The Netherlands., Hagedoorn RS; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Kester MG; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., van der Steen DM; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Rodriguez T; Research and Development, Bellicum Pharmaceuticals, Inc., Houston, TX., Pentcheva-Hoang T; Research and Development, Bellicum Pharmaceuticals, Inc., Houston, TX., de Ru AH; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands., Schoonakker MP; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Meeuwsen MH; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Griffioen M; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., van Veelen PA; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands., Falkenburg JH; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Heemskerk MH; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Blood [Blood] 2017 Mar 09; Vol. 129 (10), pp. 1284-1295. Date of Electronic Publication: 2017 Jan 04.

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Akademický článek

Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses ex vivo .

Autor: Thordardottir S; Department of Laboratory Medicine - Laboratory of Hematology, Radboud University Medical Center , Nijmegen, the Netherlands., Schaap N; Department of Hematology, Radboud University Medical Center , Nijmegen, the Netherlands., Louer E; Department of Laboratory Medicine - Laboratory of Hematology, Radboud University Medical Center , Nijmegen, the Netherlands., Kester MG; Department of Hematology, Leiden University Medical Center , Leiden, the Netherlands., Falkenburg JH; Department of Hematology, Leiden University Medical Center , Leiden, the Netherlands., Jansen J; Department of Laboratory Medicine - Laboratory of Hematology, Radboud University Medical Center , Nijmegen, the Netherlands., Radstake TR; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Hobo W; Department of Laboratory Medicine - Laboratory of Hematology, Radboud University Medical Center , Nijmegen, the Netherlands., Dolstra H; Department of Laboratory Medicine - Laboratory of Hematology, Radboud University Medical Center , Nijmegen, the Netherlands.

Publikováno v: Oncoimmunology [Oncoimmunology] 2017 Feb 06; Vol. 6 (3), pp. e1285991. Date of Electronic Publication: 2017 Feb 06 (Print Publication: 2017).

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Akademický článek

Generation of CD20-specific TCRs for TCR gene therapy of CD20low B-cell malignancies insusceptible to CD20-targeting antibodies.

Autor: Jahn L; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van der Steen DM; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Hagedoorn RS; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Hombrink P; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Department of Hematopoiesis, Sanquin Research, 1006 AD Amsterdam, The Netherlands., Kester MG; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Schoonakker MP; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., de Ridder D; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van Veelen PA; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Falkenburg JH; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Heemskerk MH; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Publikováno v: Oncotarget [Oncotarget] 2016 Nov 22; Vol. 7 (47), pp. 77021-77037.

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Akademický článek

A CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer.

Autor: Jahn L; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Hagedoorn RS; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van der Steen DM; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Hombrink P; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Department of Hematopoiesis, Sanquin Research, 1006 AD Amsterdam, The Netherlands., Kester MG; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Schoonakker MP; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., de Ridder D; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van Veelen PA; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Falkenburg JH; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Heemskerk MH; Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Publikováno v: Oncotarget [Oncotarget] 2016 Nov 01; Vol. 7 (44), pp. 71536-71547.

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