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Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes.

Autor: Wigger L; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Barovic M; Department of Molecular Diabetology, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Brunner AD; Max Planck Institute of Biochemistry, Martinsried, Germany., Marzetta F; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Schöniger E; Department of Molecular Diabetology, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Mehl F; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Kipke N; Department of Molecular Diabetology, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Friedland D; Department of Molecular Diabetology, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Burdet F; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Kessler C; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Lesche M; DRESDEN-concept Genome Center, c/o Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany., Thorens B; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Bonifacio E; Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.; Center for Regenerative Therapies Dresden, Faculty of Medicine and Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany., Legido-Quigley C; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; King's College London, London, UK., Barbier Saint Hilaire P; DMPK Center, Technologie Servier, Orléans, France., Delerive P; Institut de Recherches Servier, Pôle d'Innovation Thérapeutique Métabolisme, Suresnes, France., Dahl A; DRESDEN-concept Genome Center, c/o Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany., Klose C; Lipotype GmbH, Dresden, Germany., Gerl MJ; Lipotype GmbH, Dresden, Germany., Simons K; Lipotype GmbH, Dresden, Germany., Aust D; Department of Pathology, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; NCT Biobank Dresden, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Weitz J; Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany., Distler M; Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany., Schulte AM; Sanofi-Aventis Deutschland GmbH, Diabetes Research, Industriepark Höchst, Frankfurt am Main, Germany., Mann M; Max Planck Institute of Biochemistry, Martinsried, Germany. mmann@biochem.mpg.de., Ibberson M; Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland. Mark.Ibberson@sib.swis., Solimena M; Department of Molecular Diabetology, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany. Michele.Solimena@uniklinikum-dresden.de.; Paul Langerhans Institute Dresden (PLID), Helmholtz Center Munich, University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany. Michele.Solimena@uniklinikum-dresden.de.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. Michele.Solimena@uniklinikum-dresden.de.

Publikováno v: Nature metabolism [Nat Metab] 2021 Jul; Vol. 3 (7), pp. 1017-1031. Date of Electronic Publication: 2021 Jun 28.