Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Keshab Bhattacharya"'
Autor:
Jennifer M. Thorn, Keshab Bhattacharya, Renata Crutcher, Justin Sperry, Colleen Isele, Barbara Kelly, Libbey Yates, James Zobel, Ningli Zhang, Heather L. Davis, Michael J. McCluskie
Publikováno v:
Vaccines, Vol 5, Iss 2, p 11 (2017)
Smoking remains one of the major causes of morbidity and mortality worldwide. One approach to assisting smoking cessation is via anti-nicotine vaccines, composed of nicotine-like haptens conjugated to a carrier protein plus adjuvant(s). We have previ
Externí odkaz:
https://doaj.org/article/c9bde9921e754ec989c485e11d57098d
Autor:
Justin B. Sperry, Maire H. Caparon, Qin Zou, Qing Chang, Mark A. Massa, Paul Wright, Kristin Wucherer, Keshab Bhattacharya, Anouk Dirksen, David Robert Stead, Sandeep Kumar, Matthew B. Francis, Jake Jaffe
Publikováno v:
Bioconjugate Chemistry. 30:47-53
Conjugate vaccines prepared with the cross-reactive material 197 (CRM197) carrier protein have been successful in the clinic and are of great interest in the field of immunotherapy. One route to preparing peptide–CRM197 conjugate vaccines involves
Autor:
Jake, Jaffe, Kristin, Wucherer, Justin, Sperry, Qin, Zou, Qing, Chang, Mark A, Massa, Keshab, Bhattacharya, Sandeep, Kumar, Maire, Caparon, David, Stead, Paul, Wright, Anouk, Dirksen, Matthew B, Francis
Publikováno v:
Bioconjugate chemistry. 30(1)
Conjugate vaccines prepared with the cross-reactive material 197 (CRM
Autor:
Kyle A. Totaro, Bradley L. Pentelute, Keshab Bhattacharya, Sa V. Ho, Jennifer Marie Thorn, Jari I. Finneman, Xiaoli Liao, Mark A. Massa, Justin B. Sperry
Publikováno v:
Bioconjugate Chemistry. 27:994-1004
1-Ethyl-3-(3-(dimethylamino)propyl)carbodiimide (EDC) bioconjugations have been utilized in preparing variants for medical research. While there have been advances in optimizing the reaction for aqueous applications, there has been limited focus towa
Autor:
James F. Zobel, Libbey Anne Yates, Jennifer Marie Thorn, Colleen Isele, Michael J. McCluskie, Keshab Bhattacharya, Justin B. Sperry, Renata Crutcher, Barbara Kelly, Ningli Zhang, Heather L. Davis
Publikováno v:
Vaccines, Vol 5, Iss 2, p 11 (2017)
Vaccines
Vaccines
Smoking remains one of the major causes of morbidity and mortality worldwide. One approach to assisting smoking cessation is via anti-nicotine vaccines, composed of nicotine-like haptens conjugated to a carrier protein plus adjuvant(s). We have previ
Autor:
Brad Evans, Keith A. Davis, Joe T. Collins, Keshab Bhattacharya, Anouk Dirksen, Jari I. Finneman, Paul W. Brown, Erin Pepin, Jeffrey S. Ryczek, Ratish Mangalathillam, William B. Wellborn, Mark John Pozzo, Rory F. Finn
Publikováno v:
Biopolymers.
A scalable, viable process was developed for the Fibroblast Growth Factor 21 (FGF21) protein-antibody conjugate, CVX-343, an extended half-life therapeutic for the treatment of metabolic disease. CVX-343 utilizes the CovX antibody scaffold technology
Autor:
Mauro Mileni, Stephen Swaney, Eranthie Weerapana, Benjamin F. Cravatt, Marya Liimatta, Michele K. McKinney, Sarah E. Smith, Lazerwith Scott E, Nalini Sadagopan, David Beidler, Cory Michael Stiff, Satwik Kamtekar, Douglas S. Johnson, Keri Van Becelaere, Keshab Bhattacharya, Yanhua Zhang, Jonathan Z. Long, Kay Ahn, Raymond C. Stevens
Publikováno v:
Chemistry & Biology. 16:411-420
SummaryEndocannabinoids are lipid signaling molecules that regulate a wide range of mammalian behaviors, including pain, inflammation, and cognitive/emotional state. The endocannabinoid anandamide is principally degraded by the integral membrane enzy
Autor:
Keshab Bhattacharya, Jennifer Marie Thorn, Michael J. McCluskie, Ghania Chikh, Jari I. Finneman, Dana M. Evans, Ningli Zhang, Heather L. Davis, James R. Merson, Paul Robert Mehelic, David Robert Stead, Michele Bailey Piatchek, Janna Cartier, Parag Kolhe
Publikováno v:
International immunopharmacology. 25(2)
Anti-nicotine vaccines aim to prevent nicotine entering the brain, and thus reduce or eliminate the reward that drives nicotine addiction. Those tested in humans to date have failed to improve quit rates over placebo, possibly because antibody (Ab) r
Publikováno v:
Measurement Science and Technology. 16:1075-1082
Interferometric optical fibre sensors have proved to be many orders of magnitude more sensitive than their electrical counterparts, but they suffer from limitations in signal demodulation caused by phase ambiguity and complex fringe counting when the
Autor:
David B. Evans, Adele M. Pauley, Keshab Bhattacharya, Zhigang Wang, Jennifer A Johnston, Satish K. Sharma, Kenneth B. Rank, Timothy J. Fleck
Publikováno v:
FEBS Letters. 514:263-268
We report here that aggregated beta-amyloid (Abeta) 1-42 promotes tau aggregation in vitro in a dose-dependent manner. When Abeta-mediated aggregated tau was used as a substrate for tau protein kinase II (TPK II), an 8-fold increase in the rate of TP