Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Kesavan Meganathan"'
Autor:
Kesavan Meganathan, Ramachandran Prakasam, Dustin Baldridge, Paul Gontarz, Bo Zhang, Fumihiko Urano, Azad Bonni, Susan E. Maloney, Tychele N. Turner, James E. Huettner, John N. Constantino, Kristen L. Kroll
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-26 (2021)
Abstract Background Copy number variants (CNVs) linked to genes involved in nervous system development or function are often associated with neuropsychiatric disease. While CNVs involving deletions generally cause severe and highly penetrant patient
Externí odkaz:
https://doaj.org/article/28040e7bbee74beeb05f76bab9132942
Autor:
Emily M. A. Lewis, Kesavan Meganathan, Dustin Baldridge, Paul Gontarz, Bo Zhang, Azad Bonni, John N. Constantino, Kristen L. Kroll
Publikováno v:
Molecular Autism, Vol 10, Iss 1, Pp 1-23 (2019)
Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with pronounced heritability in the general population. This is largely attributable to the effects of polygenic susceptibility, with inherited liability exhibiting d
Externí odkaz:
https://doaj.org/article/b771a97a74a446ba8807749dd5918580
Autor:
Anja Zeigerer, Roman L. Bogorad, Kirti Sharma, Jerome Gilleron, Sarah Seifert, Susanne Sales, Nikolaus Berndt, Sascha Bulik, Giovanni Marsico, Rochelle C.J. D’Souza, Naharajan Lakshmanaperumal, Kesavan Meganathan, Karthick Natarajan, Agapios Sachinidis, Andreas Dahl, Hermann-Georg Holzhütter, Andrej Shevchenko, Matthias Mann, Victor Koteliansky, Marino Zerial
Publikováno v:
Cell Reports, Vol 11, Iss 6, Pp 884-892 (2015)
The liver maintains glucose and lipid homeostasis by adapting its metabolic activity to the energy needs of the organism. Communication between hepatocytes and extracellular environment via endocytosis is key to such homeostasis. Here, we addressed t
Externí odkaz:
https://doaj.org/article/baacc26e5eff48688b9e18a1e0dc126a
Autor:
Markus Storbeck, Kristina Hupperich, John Antonydas Gaspar, Kesavan Meganathan, Lilian Martínez Carrera, Radu Wirth, Agapios Sachinidis, Brunhilde Wirth
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89020 (2014)
Alternative splicing (AS) increases the informational content of the genome and is more prevalent in the brain than in any other tissue. The splicing factor Tra2b (Sfrs10) can modulate splicing inclusion of exons by specifically detecting GAA-rich bi
Externí odkaz:
https://doaj.org/article/c7902662dbc7407d9bcccd95bb59be23
Autor:
Kesavan Meganathan, Smita Jagtap, Vilas Wagh, Johannes Winkler, John Antonydas Gaspar, Diana Hildebrand, Maria Trusch, Karola Lehmann, Jürgen Hescheler, Hartmut Schlüter, Agapios Sachinidis
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e44228 (2012)
Embryonic development can be partially recapitulated in vitro by differentiating human embryonic stem cells (hESCs). Thalidomide is a developmental toxicant in vivo and acts in a species-dependent manner. Besides its therapeutic value, thalidomide al
Externí odkaz:
https://doaj.org/article/6b00c48684334bb5a81076f377afc156
Autor:
Irene Antony, Elizabeth D. Buttermore, Gerarda Cappuccio, Juan Cruz Casabona, Gareth Chapman, Ivy Pin-Fang Chen, Harue Chou, Laurence Daheron, Alfred K. Dei-Ampeh, Thomas M. Durcan, Sandra J. Engle, Patrick Faloon, Kevin T. FitzGerald, Deborah L. French, James Giordano, Madison R. Glass, Komal Kaushik, Robin J. Kleiman, Teun Klein Gunnewiek, Kristen L. Kroll, Felix A. Kyere, Herbert M. Lachman, Brooke Latour, Mirjana Maletic-Savatic, Xiaobo Mao, Abigail Mariga, Gilles Maussion, Kesavan Meganathan, Swati Mishra, Nael Nadif Kasri, Andrew Petersen, Luisa Pimentel, Ramachandran Prakasam, Aiko Robert, Cecilia Rocha, Manuj Shah, Jason L. Stein, Maria Sundberg, Rik Van Der Kant, Coen Van Deursen, Elisa A. Waxman, Samantha Wu, Mingyao Ying, Damian W. Young, Jessica E. Young
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54858eaa91d9b0c887066db49c4fb4e5
https://doi.org/10.1016/b978-0-12-822277-5.01002-6
https://doi.org/10.1016/b978-0-12-822277-5.01002-6
Autor:
James E. Huettner, Kristen L. Kroll, Kesavan Meganathan, Fumihiko Urano, Susan E. Maloney, Ramachandran Prakasam, Dustin Baldridge, Azad Bonni, John N. Constantino, Bo Zhang, Paul Gontarz, Tychele N. Turner
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-26 (2021)
BMC Biology
BMC Biology
Background Copy number variants (CNVs) linked to genes involved in nervous system development or function are often associated with neuropsychiatric disease. While CNVs involving deletions generally cause severe and highly penetrant patient phenotype
Autor:
Nickesha C. Anderson, Andrew J. Petersen, Pin-Fang Chen, Wardiya Afshar Saber, Kristen L. Kroll, Anita Bhattacharyya, Mustafa Sahin, Kesavan Meganathan
Publikováno v:
Stem Cell Reports
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their differentiation into neural lineages is a revolutionary experimental system for studying neurological disorders, including intellectual and developmental disabilitie
Autor:
Dustin Baldridge, Ramachandran Prakasam, Fumihiko Urano, Azad Bonni, James E. Huettner, Paul Gontarz, John N. Constantino, Kristen L. Kroll, Bo Zhang, Kesavan Meganathan
BackgroundCopy number variants at chromosome 15q13.3 contribute to liability for multiple intellectual and developmental disabilities including Autism Spectrum Disorder (ASD). Individuals with duplications of this interval, which includes the gene CH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208b9a5cf885e107d9bf2161fc10b972