Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer

Autor: Kerzeli, Iliana K., Kostakis, Alexandros, Turker, Polat, malmström, per-uno, Hemdan, Tammer, Mezheyeuski, Artur

Publikováno v: Scientia

Biomarkers; Proteomics; Urothelial bladder cancer Biomarcadores; Proteómica; Cáncer de vejiga urotelial Biomarcadors; Proteòmica; Càncer de bufeta urotelial Background Urothelial bladder cancer is most frequently diagnosed at the non-muscle-invas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3991::49461c400e64d2195696a67235e458f4
https://hdl.handle.net/11351/9987

MALT1 inhibition suppresses antigen-specific T cell responses.

Autor: Kerzeli IK; Department of Pharmacy, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Nasi A; Department of Pharmacy, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Fletcher E; Department of Pharmacy, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Chourlia A; Department of Pharmacy, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Kallin A; Medivir AB, Lunastigen 5, 141 22 Huddinge, Sweden., Finnberg N; Medivir AB, Lunastigen 5, 141 22 Huddinge, Sweden., Ersmark K; Medivir AB, Lunastigen 5, 141 22 Huddinge, Sweden., Lampinen M; Department of Pharmacy, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Albertella M; Medivir AB, Lunastigen 5, 141 22 Huddinge, Sweden., Öberg F; Medivir AB, Lunastigen 5, 141 22 Huddinge, Sweden., Mangsbo SM; Department of Pharmacy, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Electronic address: sara.mangsbo@farmaci.uu.se.

Publikováno v: Cellular immunology [Cell Immunol] 2024 Mar-Apr; Vol. 397-398, pp. 104814. Date of Electronic Publication: 2024 Feb 24.

Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations.

Autor: Kerzeli IK; Department of Pharmaceutical Biosciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Lord M; Department of Pharmaceutical Biosciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Doroszko M; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Elgendy R; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Chourlia A; Department of Pharmaceutical Biosciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Stepanek I; Department of Pharmaceutical Biosciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Larsson E; Department of Pharmaceutical Biosciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., van Hooren L; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Nelander S; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Malmstrom PU; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Dragomir A; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Segersten U; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Mangsbo SM; Department of Pharmaceutical Biosciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Publikováno v: PloS one [PLoS One] 2021 Jul 07; Vol. 16 (7), pp. e0253178. Date of Electronic Publication: 2021 Jul 07 (Print Publication: 2021).

Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses.

Autor: Fotaki G; Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Jin C; Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Ramachandran M; Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Kerzeli IK; Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Karlsson-Parra A; Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Immunicum AB., Yu D; Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Essand M; Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Publikováno v: Oncoimmunology [Oncoimmunology] 2017 Nov 27; Vol. 7 (3), pp. e1395126. Date of Electronic Publication: 2017 Nov 27 (Print Publication: 2018).