Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kerstin Wassmann"'
Autor:
Cornelius F.H. Mueller, Alexander Jung, Ulrich M. Becher, Christian Werner, Georg Nickenig, Kerstin Wassmann, Sven Wassmann, Martin Steinmetz, Sebastian Zimmer
Publikováno v:
Molecular and Cellular Biochemistry. 333:33-39
Enhanced proliferation of vascular smooth muscle cells (VSMCs) is one of the key features of the pathogenesis of atherosclerosis. The helix-loop-helix protein Inhibitor of DNA binding 3 (Id3) contributes to regulation of VSMC proliferation in a redox
Autor:
Sven Wassmann, Anja Berger, Georg Nickenig, Cornelius F.H. Mueller, Stefan Holz, Kerstin Wassmann
Publikováno v:
Biochemical and Biophysical Research Communications. 370:669-674
The AT1 receptor plays a pivotal role for the pathogenesis of hypertension and atherosclerosis. AT1 receptor expression is regulated posttranscriptionally via destabilization of the AT1 receptor mRNA by mRNA binding proteins. Recently, we identified
Publikováno v:
Current Hypertension Reports. 8:69-78
Data from numerous studies demonstrate that oxidative stress plays an important role in the pathogenesis of vascular disease. Oxidative stress leads to many pathologic events, such as inactivation of nitric oxide, lipid oxidation, enhanced mitogenici
Publikováno v:
Hypertension. 44:381-386
Pathological conditions that predispose to cardiovascular events, such as hypertension, hypercholesterolemia, and diabetes, are associated with oxidative stress. These observations and further data derived from a plethora of investigations provided a
Autor:
Talin Ebrahimian, Thomas Czech, Kerstin Wassmann, Omar Arfa, Sven Wassmann, Nikos Werner, Cathleen Endtmann, Vasileios Petoumenos, Georg Nickenig, Mathias Fritz, Ulrich Laufs
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 58(3)
Endothelial progenitor cells (EPCs) contribute to endothelial regeneration. Angiotensin II (Ang II) through Ang II type 1 receptor (AT 1 -R) activation plays an important role in vascular damage. The effect of Ang II on EPCs and the involved molecula
Autor:
Sven Wassmann, Cornelius F.H. Mueller, Kerstin Wassmann, Georg Nickenig, Ulrich M. Becher, Shazia Afzal
Publikováno v:
Journal of molecular and cellular cardiology. 49(3)
The multidrug resistance related protein-1 (MRP1) is a member of the ATP binding cassette (ABC) of cell surface transport proteins expressed in multiple cell lines and tissues including endothelial cells and haematopoietic stem cells. MRP1 blockade h
Autor:
Kerstin Wassmann, Cornelius F.H. Mueller, Georg Nickenig, Derya Sivritas, Annika Bohner, Sven Wassmann, Marc Ulrich Becher, Talin Ebrahimian, Stephanie Rapp, Omar Arfa, Takashi Umemura
Publikováno v:
Basic research in cardiology. 106(4)
The mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) and the zinc finger transcription factor Kruppel-like factor-4 (KLF4) are involved in the regulation of redox homeostasis, apoptosis and cell proliferation. We have shown tha
Autor:
Claas P. Naehle, Georg Nickenig, Andreas Zimmer, Suzin Jung, Sven Wassmann, Sebastian Zimmer, Dieter Lütjohann, Kerstin Wassmann, Vedat Tiyerili
Publikováno v:
Basic research in cardiology. 105(4)
Inhibition of the cannabinoid receptor CB(1) (CB(1)-R) exerts numerous positive cardiovascular effects such as modulation of blood pressure, insulin sensitivity and serum lipid concentrations. However, direct vascular effects of CB(1)-R inhibition re
Autor:
Georg Nickenig, Wolfram S. Kunz, Kerstin Wassmann, Julian D. Widder, Barbara Keuler, Cornelius F.H. Mueller, Chia Hui Chen, Sven Wassmann, Alexey P. Kudin
Publikováno v:
Circulation. 117(22)
Background— We recently showed that the multidrug resistance related protein-1 (MRP1) is important for the management of oxidative stress in vascular cells. However, the underlying mechanism and the in vivo relevance of these findings remain elusiv
Publikováno v:
Circulation research. 97(10)
Oxidative stress plays an important role in the pathogenesis of atherosclerosis and can be effectively influenced by radical scavenging enzymes. Estrogens exert antioxidative effects in the vasculature; however, cotreatment with progesterone may abro