Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kerstin Schott"'
Autor:
Angel Bulnes-Ramos, Kerstin Schott, Jesse Rabinowitz, Charlotte Luchsinger, Cinzia Bertelli, Eri Miyagi, Corey H. Yu, Mirjana Persaud, Caitlin Shepard, Renate König, Baek Kim, Dmitri N. Ivanov, Klaus Strebel, Felipe Diaz-Griffero
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT In humans, sterile alpha motif (SAM) domain- and histidine–aspartic acid (HD) domain-containing protein 1 (SAMHD1) is a dNTPase enzyme that prevents HIV-1 infection in non-cycling cells, such as differentiated THP-1 cells and human primary
Externí odkaz:
https://doaj.org/article/c9f56ba73d444171b8aaf82bbd3b5756
Autor:
Moritz Schüssler, Kerstin Schott, Nina Verena Fuchs, Adrian Oo, Morssal Zahadi, Paula Rauch, Baek Kim, Renate König
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4+ T cells. The anti-vira
Externí odkaz:
https://doaj.org/article/1c167ea212ec4a49b4f9019e5796d44f
Autor:
Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens, Renate König
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active i
Externí odkaz:
https://doaj.org/article/3b8f796c4d5d4e31b78e854d8aab59b2
Autor:
Wenying Lu, Rebekka Aarsand, Kerstin Schotte, Jing Han, Elizaveta Lebedeva, Elena Tsoy, Nino Maglakelidze, Joan B Soriano, Werner Bill, David M G Halpin, M. Patricia Rivera, Kwun M Fong, Hasmeena Kathuria, Arzu Yorgancıoğlu, Monika Gappa, David CL Lam, Sarah Rylance, Sukhwinder Singh Sohal
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract The WHO recently published a Tobacco Knowledge Summary (TKS) synthesizing current evidence on tobacco and COPD, aiming to raise awareness among a broad audience of health care professionals. Furthermore, it can be used as an advocacy tool in
Externí odkaz:
https://doaj.org/article/305cd0c7a29f40a48aa984ae8d6a778b
Autor:
Moritz Schüssler, Paula Rauch, Kerstin Schott, Adrian Oo, Nina Verena Fuchs, Baek Kim, Renate König
Sterile α motif (SAM) and HD domain-containing protein 1 (SAMHD1) is a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4+ T cells. As a dNTP triphosphate triphosphohydrolase (dNTPase), SAMHD1 is propos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8474c2dfc556cca71b7d3eedfc7b719
https://doi.org/10.1101/2022.01.04.475018
https://doi.org/10.1101/2022.01.04.475018
Autor:
Renate König, Markus Munder, Mirko H H Schmidt, Liam Childs, Alla Bulashevska, Kerstin Schott, Catharina Majer, Krishnaraj Rajalingam
Publikováno v:
Journal of molecular medicine, 100(3):351-372
Human sterile α motif and HD domain-containing protein 1 (SAMHD1), originally described as the major cellular deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase) balancing the intracellular deoxynucleotide (dNTP) pool, has come recently i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552eacbf8bfe11a19b15753f107833f5
https://link.springer.com/article/10.1007/s00109-021-02131-w#Sec14
https://link.springer.com/article/10.1007/s00109-021-02131-w#Sec14
Autor:
Renate König, Kerstin Schott
Publikováno v:
Trends in Microbiology. 25:243-245
Host proteins are essential for entry and replication of HIV and provide important non-viral therapeutic targets. Large-scale RNAi-based screens have identified nearly a thousand candidate host factors, but with little agreement among studies and few
Autor:
Ananda Ayyappan Jaguva Vasudevan, Baek Kim, Renate König, Karl S. Lang, Edmund Osei Kuffour, Jessica Holler, Kerstin Schott, Carsten Münk, Dieter Häussinger, Philipp A. Lang, Wolfgang A. Schulz
Publikováno v:
Journal of virology. 92(20)
The host intrinsic innate immune system drives antiviral defenses and viral restriction, which includes the production of soluble factors, such as type I and III interferon (IFN), and activation of restriction factors, including SAMHD1, a deoxynucleo
Publikováno v:
Current topics in microbiology and immunology. 419
Cells use an elaborate innate immune surveillance and defense system against virus infections. Here, we discuss recent studies that reveal how HIV-1 is sensed by the innate immune system. Furthermore, we present mechanisms on the counteraction of HIV
Publikováno v:
Roles of Host Gene and Non-coding RNA Expression in Virus Infection ISBN: 9783030053680
Cells use an elaborate innate immune surveillance and defense system against virus infections. Here, we discuss recent studies that reveal how HIV-1 is sensed by the innate immune system. Furthermore, we present mechanisms on the counteraction of HIV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1911f04b2ba213429d7115a16da1ee82
https://doi.org/10.1007/82_2017_29
https://doi.org/10.1007/82_2017_29