Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kerstin Schafer-Eckart"'
Autor:
David Baden, Sven Zukunft, Gema Hernandez, Nadine Wolgast, Sophie Steinhauser, Alexander Pohlmann, Christoph Schliemann, Jan-Henrik Mikesch, Bjorn Steffen, Tim Sauer, Maher Hanoun, Kerstin Schafer-Eckart, Stefan W. Krause, Mathias Hanel, Hermann Einsele, Edgar Jost, Tim H. Brummendorf, Sebastian Scholl, Andreas Hochhaus, Andreas Neubauer, Andreas Burchert, Martin Kaufmann, Dirk Niemann, Markus Schaich, Wolfgang Blau, Alexander Kiani, Martin Gorner, Ulrich Kaiser, Johannes Kullmer, Thomas Weber, Wolfgang E Berdel, Gerhard Ehninger, Carsten Muller-Tidow, Uwe Platzbecker, Hubert Serve, Martin Bornhauser, Christoph Rollig, Claudia D Baldus, Lars Fransecky
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
In newly diagnosed acute myeloid leukemia, immediate initiation of treatment is standard of care. However, deferral of antileukemic therapy may be indicated to assess comorbidities or pre-therapeutic risk factors. We explored the impact of time from
Externí odkaz:
https://doaj.org/article/a18a7d664edd4e4590ac8fdec959dd27
Autor:
Jan-Niklas Eckardt, Waldemar Hahn, Christoph Röllig, Sebastian Stasik, Uwe Platzbecker, Carsten Müller-Tidow, Hubert Serve, Claudia D. Baldus, Christoph Schliemann, Kerstin Schäfer-Eckart, Maher Hanoun, Martin Kaufmann, Andreas Burchert, Christian Thiede, Johannes Schetelig, Martin Sedlmayr, Martin Bornhäuser, Markus Wolfien, Jan Moritz Middeke
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Clinical research relies on high-quality patient data, however, obtaining big data sets is costly and access to existing data is often hindered by privacy and regulatory concerns. Synthetic data generation holds the promise of effectively by
Externí odkaz:
https://doaj.org/article/41c3e7d761b34403bf733f68f1cca5e0
Autor:
Julia-Annabell Georgi, Sebastian Stasik, Jan-Niklas Eckardt, Sven Zukunft, Marita Hartwig, Christoph Röllig, Jan Moritz Middeke, Uta Oelschlägel, Utz Krug, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Tim H. Brümmendorf, Ralph Naumann, Björn Steffen, Hermann Einsele, Markus Schaich, Andreas Burchert, Andreas Neubauer, Kerstin Schäfer-Eckart, Christoph Schliemann, Stefan W. Krause, Mathias Hänel, Richard Noppeney, Ulrich Kaiser, Claudia D. Baldus, Martin Kaufmann, Carsten Müller-Tidow, Uwe Platzbecker, Wolfgang E. Berdel, Hubert Serve, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig, Frank Kroschinsky, Christian Thiede, Study Alliance Leukemia (SAL)
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Tandem-duplication mutations of the UBTF gene (UBTF-TDs) coding for the upstream binding transcription factor have recently been described in pediatric patients with acute myeloid leukemia (AML) and were found to be associated with particula
Externí odkaz:
https://doaj.org/article/0565ea65de654675a35a8905aa9c8f36
Autor:
Jan-Niklas Eckardt, Christoph Röllig, Klaus Metzeler, Peter Heisig, Sebastian Stasik, Julia-Annabell Georgi, Frank Kroschinsky, Friedrich Stölzel, Uwe Platzbecker, Karsten Spiekermann, Utz Krug, Jan Braess, Dennis Görlich, Cristina Sauerland, Bernhard Woermann, Tobias Herold, Wolfgang Hiddemann, Carsten Müller-Tidow, Hubert Serve, Claudia D. Baldus, Kerstin Schäfer-Eckart, Martin Kaufmann, Stefan W. Krause, Mathias Hänel, Wolfgang E. Berdel, Christoph Schliemann, Jiri Mayer, Maher Hanoun, Johannes Schetelig, Karsten Wendt, Martin Bornhäuser, Christian Thiede, Jan Moritz Middeke
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-13 (2023)
Abstract Background Increasingly large and complex biomedical data sets challenge conventional hypothesis-driven analytical approaches, however, data-driven unsupervised learning can detect inherent patterns in such data sets. Methods While unsupervi
Externí odkaz:
https://doaj.org/article/c4960d518e3d43029bd21cdce38e327f
Autor:
Jan-Niklas Eckardt, Sebastian Stasik, Christoph Röllig, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. Brümmendorf, Ralph Naumann, Björn Steffen, Volker Kunzmann, Hermann Einsele, Markus Schaich, Andreas Burchert, Andreas Neubauer, Kerstin Schäfer-Eckart, Christoph Schliemann, Stefan W. Krause, Regina Herbst, Mathias Hänel, Maher Hanoun, Ulrich Kaiser, Martin Kaufmann, Zdenek Rácil, Jiri Mayer, Tiago Cerqueira, Frank Kroschinsky, Wolfgang E. Berdel, Hubert Serve, Carsten Müller-Tidow, Uwe Platzbecker, Claudia D. Baldus, Johannes Schetelig, Timo Siepmann, Martin Bornhäuser, Jan Moritz Middeke, Christian Thiede
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Functional perturbations of the cohesin complex with subsequent changes in chromatin structure and replication are reported in a multitude of cancers including acute myeloid leukemia (AML). Mutations of its STAG2 subunit may predict unfavora
Externí odkaz:
https://doaj.org/article/80bac00bb1434846a10e015d95c2ab03
Autor:
Desiree Kunadt, Sebastian Stasik, Klaus H. Metzeler, Christoph Röllig, Christoph Schliemann, Philipp A. Greif, Karsten Spiekermann, Maja Rothenberg-Thurley, Utz Krug, Jan Braess, Alwin Krämer, Andreas Hochhaus, Sebastian Scholl, Inken Hilgendorf, Tim H. Brümmendorf, Edgar Jost, Björn Steffen, Gesine Bug, Hermann Einsele, Dennis Görlich, Cristina Sauerland, Kerstin Schäfer-Eckart, Stefan W. Krause, Mathias Hänel, Maher Hanoun, Martin Kaufmann, Bernhard Wörmann, Michael Kramer, Katja Sockel, Katharina Egger-Heidrich, Tobias Herold, Gerhard Ehninger, Andreas Burchert, Uwe Platzbecker, Wolfgang E. Berdel, Carsten Müller-Tidow, Wolfgang Hiddemann, Hubert Serve, Matthias Stelljes, Claudia D. Baldus, Andreas Neubauer, Johannes Schetelig, Christian Thiede, Martin Bornhäuser, Jan M. Middeke, Friedrich Stölzel, the A. M. L. Cooperative Group (AMLCG), Study Alliance Leukemia (SAL)
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-15 (2022)
Abstract Background The role of allogeneic hematopoietic cell transplantation (alloHCT) in acute myeloid leukemia (AML) with mutated IDH1/2 has not been defined. Therefore, we analyzed a large cohort of 3234 AML patients in first complete remission (
Externí odkaz:
https://doaj.org/article/1665eacc6b1a46028a7f2723eae46d4a
Autor:
Marius Bill, Leo Ruhnke, Sven Zukunft, Silvia Schäfer, Jan-Niklas Eckardt, Sebastian Stasik, Maher Hanoun, Thomas Schroeder, Lars Fransecky, Björn Steffen, Stefan W. Krause, Sebastian Scholl, Andreas Hochhaus, Tim Sauer, Sabrina Kraus, Kerstin Schäfer-Eckart, Martin Kaufmann, Edgar Jost, Tim H Brümmendorf, Christoph Schliemann, Jan-Henrik Mikesch, Utz Krug, Mathias Hänel, Anke Morgner, Markus Schaich, Andreas Neubauer, Roland Repp, Dirk Niemann, Ruth Seggewiss-Bernhardt, Achim Meinhardt, Johannes Kullmer, Ulrich Kaiser, Wolfgang Blau, Alexander Kiani, Götz Ulrich Grigoleit, Aristoteles Giagounidis, Alexander Wurm, Heidi Altmann, Jan Moritz Middeke, Johannes Schetelig, Carsten Müller-Tidow, Friedrich Stölzel, Claudia Baldus, Uwe Platzbecker, Hubert Serve, Martin Bornhäuser, Christian Thiede, Christoph Röllig
Publikováno v:
HemaSphere, Vol 7, p e72156a7 (2023)
Externí odkaz:
https://doaj.org/article/4f60a7cb94af465e91534560db0cc6e5
Autor:
Wally Ferraro, Aurelio Civilleri, Clemens Gögele, Camilla Carbone, Ilenia Vitrano, Francesco Carfi Pavia, Valerio Brucato, Vincenzo La Carrubba, Christian Werner, Kerstin Schäfer-Eckart, Gundula Schulze-Tanzil
Publikováno v:
Polymers, Vol 16, Iss 3, p 331 (2024)
Bilayer scaffolds could provide a suitable topology for osteochondral defect repair mimicking cartilage and subchondral bone architecture. Hence, they could facilitate the chondro- and osteogenic lineage commitment of multipotent mesenchymal stromal
Externí odkaz:
https://doaj.org/article/ef5c5bd71ab74347b3e60de0337c7998
Autor:
Jan-Niklas Eckardt, Friedrich Stölzel, Desiree Kunadt, Christoph Röllig, Sebastian Stasik, Lisa Wagenführ, Korinna Jöhrens, Friederike Kuithan, Alwin Krämer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. Brümmendorf, Ralph Naumann, Björn Steffen, Volker Kunzmann, Hermann Einsele, Markus Schaich, Andreas Burchert, Andreas Neubauer, Kerstin Schäfer-Eckart, Christoph Schliemann, Stefan W. Krause, Regina Herbst, Mathias Hänel, Maher Hanoun, Ulrich Kaiser, Martin Kaufmann, Zdenek Rácil, Jiri Mayer, Frank Kroschinsky, Wolfgang E. Berdel, Gerhard Ehninger, Hubert Serve, Carsten Müller-Tidow, Uwe Platzbecker, Claudia D. Baldus, Johannes Schetelig, Martin Bornhäuser, Christian Thiede, Jan Moritz Middeke
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-13 (2022)
Abstract Background Extramedullary manifestations (EM) are rare in acute myeloid leukemia (AML) and their impact on clinical outcomes is controversially discussed. Methods We retrospectively analyzed a large multi-center cohort of 1583 newly diagnose
Externí odkaz:
https://doaj.org/article/7c229e9c63c24005bd9dc3138d4201e7
Autor:
Sabine Kayser, David Martínez-Cuadrón, Rebeca Rodriguez-Veiga, Mathias Hänel, Mar Tormo, Kerstin Schäfer-Eckart, Carmen Botella, Friedrich Stölzel, Teresa Bernal del Castillo, Ulrich Keller, Carlos Rodriguez-Medina, Gerhard Held, Maria-Luz Amigo, Christoph Schliemann, Mercedes Colorado, Martin Kaufmann, Manuel Barrios Garcia, Stefan W. Krause, Martin Görner, Edgar Jost, Björn Steffen, Sven Zukunft, Uwe Platzbecker, Anthony D. Ho, Claudia D. Baldus, Hubert Serve, Carsten Müller-Tidow, Christian Thiede, Martin Bornhäuser, Pau Montesinos, Christoph Röllig, Richard F. Schlenk
Publikováno v:
Haematologica, Vol 108, Iss 8 (2023)
We retrospectively studied 97 acute myeloid leukemia patients with trisomy 19 (median age at diagnosis 57 years; range, 17- 83 years) treated between 2001 and 2019 within two multicenter study groups. Trisomy 19 occurred alone in ten (10.5%) patients
Externí odkaz:
https://doaj.org/article/31bde89fd8cf4147a028bc0c80771b36