Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Kerstin Menck"'
Autor:
Suganja Chandrabalan, Linh Dang, Uwe Hansen, Melanie Timmen, Corinna Wehmeyer, Richard Stange, Tim Beißbarth, Claudia Binder, Annalen Bleckmann, Kerstin Menck
Publikováno v:
Biological Procedures Online, Vol 26, Iss 1, Pp 1-17 (2024)
Abstract Background Osteoclasts are the tissue-specific macrophage population of the bone and unique in their bone-resorbing activity. Hence, they are fundamental for bone physiology in health and disease. However, efficient protocols for the isolati
Externí odkaz:
https://doaj.org/article/1c6c35f19f30456b964c2af20178a2ad
Autor:
Anna-Maria Diedrich, Assal Daneshgar, Peter Tang, Oliver Klein, Annika Mohr, Olachi A. Onwuegbuchulam, Sabine von Rueden, Kerstin Menck, Annalen Bleckmann, Mazen A. Juratli, Felix Becker, Igor M. Sauer, Karl H. Hillebrandt, Andreas Pascher, Benjamin Struecker
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-16 (2024)
Abstract Background The extracellular matrix (ECM) is a three-dimensional network of proteins that encases and supports cells within a tissue and promotes physiological and pathological cellular differentiation and functionality. Understanding the co
Externí odkaz:
https://doaj.org/article/184b7542c395420292ac63157f983099
Autor:
Nadja Schöne, Marcel Kemper, Kerstin Menck, Georg Evers, Carolin Krekeler, Arik Bernard Schulze, Georg Lenz, Eva Wardelmann, Claudia Binder, Annalen Bleckmann
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract Immunotherapy has revolutionized the treatment of patients with non‐small cell lung cancer (NSCLC). High expression of tissue PD‐L1 (tPD‐L1) is currently the only approved biomarker for predicting treatment response. However, even tPD
Externí odkaz:
https://doaj.org/article/33b401bedfa54e9ba0cbe7aa50c5a449
Autor:
Barnabas Irmer, Janes Efing, Lea Elisabeth Reitnauer, Allegra Angenendt, Saskia Heinrichs, Antonia Schubert, Matthias Schulz, Claudia Binder, Joke Tio, Uwe Hansen, Christiane Geyer, Mirjam Gerwing, Annalen Bleckmann, Kerstin Menck
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Extracellular vesicles (EVs) harbor a plethora of different biomolecules, which they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a favorable tumor microenvironment. So far, EV uptake an
Externí odkaz:
https://doaj.org/article/2d48326b02b54a75a3384e4a27350f60
Autor:
Kerstin Menck, Saskia Heinrichs, Darius Wlochowitz, Maren Sitte, Helen Noeding, Andreas Janshoff, Hannes Treiber, Torben Ruhwedel, Bawarjan Schatlo, Christian von der Brelie, Stefan Wiemann, Tobias Pukrop, Tim Beißbarth, Claudia Binder, Annalen Bleckmann
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
Abstract Background Breast cancer has been associated with activation of the WNT signaling pathway, although no driver mutations in WNT genes have been found yet. Instead, a high expression of the alternative WNT receptor ROR2 was observed, in partic
Externí odkaz:
https://doaj.org/article/d0a5a0c967764391a19be071ba9a9dca
Autor:
Carolin Krekeler, Klaus Wethmar, Jan-Henrik Mikesch, Andrea Kerkhoff, Kerstin Menck, Georg Lenz, Hans-Ulrich Schildhaus, Michael Wessolly, Matthias W. Hoffmann, Andreas Pascher, Inga Asmus, Eva Wardelmann, Annalen Bleckmann
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12056 (2023)
DNA mismatch repair deficient (dMMR) and microsatellite instable (MSI) metastatic colorectal cancer (mCRC) can be successfully treated with FDA- and EMA-approved immune checkpoint inhibitors (ICI) pembrolizumab and nivolumab (as single agents targeti
Externí odkaz:
https://doaj.org/article/d54ab952bd2342a491d0c232b97b1a54
Autor:
Hryhorii Chereda, Annalen Bleckmann, Kerstin Menck, Júlia Perera-Bel, Philip Stegmaier, Florian Auer, Frank Kramer, Andreas Leha, Tim Beißbarth
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)
Abstract Background Contemporary deep learning approaches show cutting-edge performance in a variety of complex prediction tasks. Nonetheless, the application of deep learning in healthcare remains limited since deep learning methods are often consid
Externí odkaz:
https://doaj.org/article/f1afd85784f749c9a222fea3c981750d
Autor:
Judith Buentzel, Henry Gerd Klemp, Ralph Kraetzner, Matthias Schulz, Gry Helene Dihazi, Frank Streit, Annalen Bleckmann, Kerstin Menck, Darius Wlochowitz, Claudia Binder
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13540 (2021)
Malignant cells differ from benign ones in their metabolome and it is largely unknown whether this difference is reflected in the metabolic profile of their microvesicles (MV), which are secreted into the blood of cancer patients. Here, they are pres
Externí odkaz:
https://doaj.org/article/65e773cb3acc4f6daf595dc149b1f59c
Publikováno v:
Cells, Vol 10, Iss 1, p 142 (2021)
The WNT pathway is one of the major signaling cascades frequently deregulated in human cancer. While research had initially focused on signal transduction centered on β-catenin as a key effector activating a pro-tumorigenic transcriptional response,
Externí odkaz:
https://doaj.org/article/e2b0d9057bcb4f408efecf8b36bba28e
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5373 (2020)
Extracellular vesicles (EV) are secreted by all cell types in a tumor and its microenvironment (TME), playing an essential role in intercellular communication and the establishment of a TME favorable for tumor invasion and metastasis. They encompass
Externí odkaz:
https://doaj.org/article/b2bf69b553fe4703a3c80364f8f57e55