Zobrazeno 1 - 10 of 74 pro vyhledávání: '"Kerstin Jahn"'
1
Akademický článek
A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice
Autor: Xiaobo Wang, Mark R. Sommerfeld, Kerstin Jahn‐Hofmann, Bishuang Cai, Aveline Filliol, Helen E. Remotti, Robert F. Schwabe, Aimo Kannt, Ira Tabas
Publikováno v: Hepatology Communications, Vol 3, Iss 9, Pp 1221-1234 (2019)
Nonalcoholic steatohepatitis (NASH) is emerging as a major public health issue and is associated with significant liver‐related morbidity and mortality. At present, there are no approved drug therapies for NASH. The transcriptional coactivator with
Externí odkaz: https://doaj.org/article/1e86ca922c85434d9c6ee005837b7f83
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2
Akademický článek
A siRNA mediated hepatic dpp4 knockdown affects lipid, but not glucose metabolism in diabetic mice.
Autor: Sven Wolfgang Görgens, Kerstin Jahn-Hofmann, Dinesh Bangari, Sheila Cummings, Christiane Metz-Weidmann, Uwe Schwahn, Paulus Wohlfart, Matthias Schäfer, Maximilian Bielohuby
Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0225835 (2019)
Systemic inhibition of dipeptidyl peptidase 4 (dpp4) represents an effective and established treatment option for type 2 diabetes (T2D). The current study investigated in mice if a liver selective knock-down of dpp4 by therapeutic siRNAs could be a n
Externí odkaz: https://doaj.org/article/bdc859f279094f99bbdd641ba03b1a8b
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3
Akademický článek
Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice
Autor: Sebastian Brachs, Angelika F. Winkel, Hui Tang, Andreas L. Birkenfeld, Bodo Brunner, Kerstin Jahn-Hofmann, Daniel Margerie, Hartmut Ruetten, Dieter Schmoll, Joachim Spranger
Publikováno v: Molecular Metabolism, Vol 5, Iss 11, Pp 1072-1082 (2016)
Objective: Non-alcoholic fatty liver disease is a world-wide health concern and risk factor for cardio-metabolic diseases. Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotrans
Externí odkaz: https://doaj.org/article/e5e65e2ccada43378f7614a3e68e2670
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5
Akademický článek
Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice.
Autor: Sebastian Brachs, Angelika F Winkel, James Polack, Hui Tang, Maria Brachs, Daniel Margerie, Bodo Brunner, Kerstin Jahn-Hofmann, Hartmut Ruetten, Joachim Spranger, Dieter Schmoll
Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0166110 (2016)
The transcription factor NF-E2-related factor 2 (Nrf2) induces cytoprotective genes, but has also been linked to the regulation of hepatic energy metabolism. In order to assess the pharmacological potential of hepatic Nrf2 activation in metabolic dis
Externí odkaz: https://doaj.org/article/83030c9dcb7343af9651ba7750e146b5
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6
Akademický článek
Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies
Autor: Britta Schneider, Michael Grote, Matthias John, Alexander Haas, Birgit Bramlage, Ludger M lckenstein, Kerstin Jahn-Hofmann, Frieder Bauss, Weijun Cheng, Rebecca Croasdale, Karin Daub, Simone Dill, Eike Hoffmann, Wilma Lau, Helmut Burtscher, James L Ludtke, Silke Metz, Olaf Mundigl, Zane C Neal, Werner Scheuer, Jan Stracke, Hans Herweijer, Ulrjch Brinkmann
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Bispecific antibodies (bsAbs) that bind to cell surface antigens and to digoxigenin (Dig) were used for targeted small interfering RNA (siRNA) delivery. They are derivatives of immunoglobulins G (IgGs) that bind tumor antigens, such as Her2, IGF1-R,
Externí odkaz: https://doaj.org/article/6bec11c8644d43c8bfff095546e986f7
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7
Akademický článek
Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection.
Autor: Miguel Prudêncio, Cristina D Rodrigues, Michael Hannus, Cécilie Martin, Eliana Real, Lígia A Gonçalves, Céline Carret, Robert Dorkin, Ingo Röhl, Kerstin Jahn-Hoffmann, Adrian J F Luty, Robert Sauerwein, Christophe J Echeverri, Maria M Mota
Publikováno v: PLoS Pathogens, Vol 4, Iss 11, p e1000201 (2008)
Plasmodium sporozoites, the causative agent of malaria, are injected into their vertebrate host through the bite of an infected Anopheles mosquito, homing to the liver where they invade hepatocytes to proliferate and develop into merozoites that, upo
Externí odkaz: https://doaj.org/article/ee3d77daad3b4c33b7108927f3fa883c
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