The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling

Autor: Leah Schembs, Ariane Willems, Kerstin Hasenpusch-Theil, James D. Cooper, Katie Whiting, Karen Burr, Sunniva M.K. Bøstrand, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Thomas Theil

Publikováno v: Cell Reports, Vol 39, Iss 7, Pp 110811- (2022)

Summary: Defects in primary cilia, cellular antennas that control multiple intracellular signaling pathways, underlie several neurodevelopmental disorders, but it remains unknown how cilia control essential steps in human brain formation. Here, we sh

Externí odkaz: https://doaj.org/article/bdacfe54fbb54aa281ae7e58ff835c24

A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development

Autor: Kerstin Hasenpusch-Theil, Christine Laclef, Matt Colligan, Eamon Fitzgerald, Katherine Howe, Emily Carroll, Shaun R Abrams, Jeremy F Reiter, Sylvie Schneider-Maunoury, Thomas Theil

Publikováno v: eLife, Vol 9 (2020)

During the development of the cerebral cortex, neurons are generated directly from radial glial cells or indirectly via basal progenitors. The balance between these division modes determines the number and types of neurons formed in the cortex thereb

Externí odkaz: https://doaj.org/article/4ec1b1854e624433b874c7c5f09a5255

The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms

Autor: Justus Schneider, Hilmar Bading, Thomas Theil, Giles E. Hardingham, Jamie McQueen, Oliver Kann, Kerstin Hasenpusch-Theil, Carlos Bas-Orth, Andrea Lewen

Publikováno v: Bas-Orth, C, Schneider, J, Lewen, A, McQueen, J, Hasenpusch-Theil, K, Theil, T, Hardingham, G E, Bading, H & Kann, O 2020, ' The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms ', Journal of Cerebral Blood Flow and Metabolism, vol. 40, no. 11, pp. 2225-2239 . https://doi.org/10.1177/0271678X19887777
J Cereb Blood Flow Metab

The role of the mitochondrial calcium uniporter (MCU) gene ( Mcu) in cellular energy homeostasis and generation of electrical brain rhythms is widely unknown. We investigated this issue in mice and rats using Mcu-knockout and -knockdown strategies in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fc49faebc9bd771cb301ffee15b813
https://doi.org/10.1177/0271678x19887777

The Multifaceted Roles of Primary Cilia in the Development of the Cerebral Cortex

Autor: Kerstin Hasenpusch-Theil, Thomas Theil

Publikováno v: Frontiers in Cell and Developmental Biology
Hasenpusch-Theil, K & Theil, T 2021, ' The multifaceted roles of primary cilia in the development of the cerebral cortex ', Frontiers in Cell and Developmental Biology . https://doi.org/10.3389/fcell.2021.630161
Frontiers in Cell and Developmental Biology, Vol 9 (2021)

The primary cilium, a microtubule based organelle protruding from the cell surface and acting as an antenna in multiple signaling pathways, takes center stage in the formation of the cerebral cortex, the part of the brain that performs highly complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162dcec3742e50712fc68d0a8b3284f5
https://pubmed.ncbi.nlm.nih.gov/33604340

Author response: A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development

Autor: Thomas Theil, Eamon Fitzgerald, Sylvie Schneider-Maunoury, Emily Carroll, Kerstin Hasenpusch-Theil, Katherine Howe, Shaun R Abrams, Jeremy F. Reiter, Matt Colligan, Christine Laclef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::817d44f08dd49a3193e120a011a3bafe
https://doi.org/10.7554/elife.58162.sa2