Requirements for Protein Phosphorylation and the Kinase Activity of Polo-like Kinase 1 (Plk1) for the Kinetochore Function of Mitotic Arrest Deficiency Protein 1 (Mad1)

Autor: Yan Li, Michael D. Ward, Kerstin Haller, Kuan-Teh Jeang, Ya-Hui Chi, O. John Semmes

Publikováno v: Journal of Biological Chemistry. 283:35834-35844

Mitotic arrest deficiency protein 1 (Mad1) is associated with microtubule-unattached kinetochores in mitotic cells and is a component of the spindle assembly checkpoint (SAC). Here, we have studied the phosphorylation of Mad1 and mapped using liquid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9ec7a106030d034c2ab1bd743e87e6
https://doi.org/10.1074/jbc.m804967200

Histone Acetyltransferase hALP and Nuclear Membrane Protein hsSUN1 Function in De-condensation of Mitotic Chromosomes

Autor: Jean-Marie Peloponese, Kuan-Teh Jeang, Ya-Hui Chi, Kerstin Haller

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, 282 (37), pp.27447-27458. ⟨10.1074/jbc.M703098200⟩

International audience; Replicated mammalian chromosomes condense to segregate during anaphase, and they de-condense at the conclusion of mitosis. Currently, it is not understood what the factors and events are that specify de-condensation. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c393299374e6c21a0fc36969f1b17d
https://hal.archives-ouvertes.fr/hal-02137882/document

Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein

Autor: Akiko Miyazato, Kuan-Teh Jeang, Jean-Marie Peloponese, Kerstin Haller

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2005, 102 (52), pp.18974-18979. ⟨10.1073/pnas.0506659103⟩

International audience; Human T cell leukemia virus type-1 (HTLV-1) is an oncogenic retrovirus etiologically causal of adult T cell leukemia. The virus encodes a Tax oncoprotein that functions in transcriptional regulation, cell cycle control, and tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf7ef2292d8b41e6b61f2c2ebe5e956
https://hal.archives-ouvertes.fr/hal-02137892

Segregation of NF-κB activation through NEMO/IKKγ by Tax and TNFα: implications for stimulus-specific interruption of oncogenic signaling

Autor: Jean Marie Peloponese, Akiko Miyazato, Karen V. Kibler, Venkat R. K. Yedavalli, Hidekatsu Iha, Kerstin Haller, Kuan-Teh Jeang, Takefumi Kasai

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2003, 22 (55), pp.8912-8923. ⟨10.1038/sj.onc.1207058⟩

International audience; Nuclear factor-kappaB essential modulator (NEMO), also called IKKgamma, has been proposed as a 'universal' adaptor of the I-kappaB kinase (IKK) complex for stimuli such as proinflammatory cytokines, microbes, and the HTLV-I Ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db01575428a69e82ae3ce139ea39743a
https://hal.archives-ouvertes.fr/hal-02137967

Tax-dependent stimulation of G1 phase-specific cyclin-dependent kinases and increased expression of signal transduction genes characterize HTLV type 1-transformed T cells

Autor: Elisabeth Derow, Domenica Saul, Iris Schmitt, Kerstin Haller, Tobias Ruckes, Ralph Grassmann

Publikováno v: AIDS research and human retroviruses. 16(16)

Human T cell leukemia virus protein induces T cells to permanent IL-2-dependent growth. These cells occasionally convert to factor independence. The viral oncoprotein Tax acts as an essential growth factor of transformed lymphocytes and stimulates th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f157ff73a814b91ae92e0d67e64b708
https://pubmed.ncbi.nlm.nih.gov/11080810