Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kerstin Hadamek"'
Autor:
Marian Brenner, Christoph Zink, Linda Witzinger, Angelika Keller, Kerstin Hadamek, Sebastian Bothe, Martin Neuenschwander, Carmen Villmann, Jens Peter von Kries, Hermann Schindelin, Elisabeth Jeanclos, Antje Gohla
Publikováno v:
eLife, Vol 13 (2024)
Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation improves cogn
Externí odkaz:
https://doaj.org/article/2acd61b1b59445af81ae1d6f654bae80
Autor:
Elisabeth Jeanclos, Jan Schlötzer, Kerstin Hadamek, Natalia Yuan-Chen, Mohammad Alwahsh, Robert Hollmann, Stefanie Fratz, Dilan Yesilyurt-Gerhards, Tina Frankenbach, Daria Engelmann, Angelika Keller, Alexandra Kaestner, Werner Schmitz, Martin Neuenschwander, Roland Hergenröder, Christoph Sotriffer, Jens Peter von Kries, Hermann Schindelin, Antje Gohla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Targeting cellular glucose metabolism is a therapeutic strategy in human diseases such as autoimmunity or cancer. Here, the authors demonstrate the druggability of phosphoglycolate phosphatase, and validate an alternative approach to control glycolys
Externí odkaz:
https://doaj.org/article/fece9c1dab514555a6b20fa9b7dd7974
Dissection and Explant Culture of Murine Allantois for the In Vitro Analysis of Allantoic Attachment
Publikováno v:
Journal of Visualized Experiments.
The placenta is essential for the growth and development of mammalian embryos. For this reason, numerous genetic alterations and likely also environmental insults that disturb placenta development or function can cause early pregnancy loss in mice an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d3ecfb077d7c1a2d86efe850e16b50
https://doi.org/10.3791/56712
https://doi.org/10.3791/56712
Autor:
Elisabeth Jeanclos, Martin J. Mueller, Annegrit Seifried, Antje Gohla, Agnes Fekete, Kerstin Hadamek, Frank Koentgen, Manfred Gessler, Matthias Zundler, Gabriela Segerer
Publikováno v:
Scientific Reports
Mammalian phosphoglycolate phosphatase (PGP) is thought to target phosphoglycolate, a 2-deoxyribose fragment derived from the repair of oxidative DNA lesions. However, the physiological role of this activity and the biological function of the DNA dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5441a2c02e64a9bb2ddff43573a30c1
http://europepmc.org/articles/PMC5059750
http://europepmc.org/articles/PMC5059750
Publikováno v:
Nature Genetics. 31:311-315
A substantial percentage of human pregnancies are lost as spontaneous abortions after implantation. This is often caused by an inadequately developed placenta. Proper development of the placental vascular system is essential to nutrient and gas excha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1842864465e8c07c7527578ca9a947
https://doi.org/10.1038/ng919
https://doi.org/10.1038/ng919
Autor:
Frank Wiesmann, Martin J. Lohse, Lorenz Meinel, Jörg Peters, Lutz Hein, Andreas Simm, Kerstin Hadamek, Marc Brede, Axel Haase, Stefan Engelhardt
Publikováno v:
Circulation. 104:2602-2607
Background Angiotensin II activates 2 distinct G protein–coupled receptors, the AT 1 and AT 2 receptors. Most of the known cardiovascular effects of angiotensin II are mediated by the AT 1 receptor subtype. The aim of the present study was to test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45942f7397a9ec992d20c9ecad2081b9
https://doi.org/10.1161/hc4601.099401
https://doi.org/10.1161/hc4601.099401
Autor:
Bela Szabo, Ralf Gilsbach, Kerstin Hadamek, Lutz Hein, Johanna Schneider, Christoph Röser, Nadine Beetz, Michal J. Urbanski, Melanie Philipp, Miriam Haubold, Jost Leemhuis, Marc Brede, David Weinshenker
Publikováno v:
Molecular pharmacology. 75(5)
Alpha(2)-adrenoceptors mediate diverse functions of the sympathetic system and are targets for the treatment of cardiovascular disease, depression, pain, glaucoma, and sympathetic activation during opioid withdrawal. To determine whether alpha(2)-adr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971d8b12912ab8d4063922719225f4a1
https://pubmed.ncbi.nlm.nih.gov/19251826
https://pubmed.ncbi.nlm.nih.gov/19251826
Autor:
Roland Hetzer, Marc Brede, Lutz Hein, Berthold Hocher, Hans B. Lehmkuhl, Kerstin Hadamek, Vera Regitz-Zagrosek, Martin Bettmann, Carolin Gerstner
Publikováno v:
Regitz-Zagrosek, Vera; Hocher, Berthold; Bettmann, Martin; Brede, Marc; Hadamek, Kerstin; Gerstner, Carolin; Lehmkuhl, Hans Brendan; Hetzer, Roland; Hein, Lutz (2006). α2C-Adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy. European Heart Journal, 27(4), pp. 454-459. Oxford University Press 10.1093/eurheartj/ehi659
Aims The sympathetic nervous system plays a central role in cardiac growth but its overstimulation is associated with increased mortality in patients with chronic heart failure. Pre-synaptic α2-adrenoceptors are essential feedback regulators to cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c6d7d8473e63890bbd381508e6a2f7
https://boris.unibe.ch/115815/
https://boris.unibe.ch/115815/
Autor:
Marc Brede, Stefan Neubauer, Frank Wiesmann, Martin J. Lohse, Carsten Arnolt, Roland Jahns, Lutz Hein, Kerstin Hadamek
Publikováno v:
Circulation. 106(19)
Background— Elevated plasma norepinephrine levels are associated with increased mortality in patients and in animal models with chronic heart failure. To test which α 2 -adrenoceptor subtypes operate as presynaptic inhibitory receptors to control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa94b0d61d3deda452da1a9236fb1805
https://pubmed.ncbi.nlm.nih.gov/12417535
https://pubmed.ncbi.nlm.nih.gov/12417535