Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kerstin Haas"'
Autor:
Maja C. Stöber, Rocío Chamorro González, Lotte Brückner, Thomas Conrad, Nadine Wittstruck, Annabell Szymansky, Angelika Eggert, Johannes H. Schulte, Richard P. Koche, Anton G. Henssen, Roland F. Schwarz, Kerstin Haase
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114711- (2024)
Summary: Neuroblastoma exhibits significant inter- and intra-tumor genetic heterogeneity and varying clinical outcomes. Extrachromosomal DNAs (ecDNAs) may drive this heterogeneity by independently segregating during cell division, leading to rapid on
Externí odkaz:
https://doaj.org/article/ab3a75bbde6043eaa8410044fc79d0e5
Autor:
Clinton Turner, Richard A. Scolyer, Pippa Corrie, Peter M. Ferguson, Kim Wong, Iman Osman, Georgina V. Long, David J. Adams, Kerstin Haas, Morgan R. Davidson, Patrick O. Emanuel, Roy Rabbie, Christine Parkinson, Jodi M. Saunus, Una Moran, Brindha Shivalingam, Dominique-Laurent Couturier, Sunil R. Lakhani
Publikováno v:
British Journal of Cancer
Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440
Brain metastases are a major cause of melanoma-related mortality and morbidity. We undertook whole-exome sequencing of 50 tumours from patients undergoing surgical resect
Brain metastases are a major cause of melanoma-related mortality and morbidity. We undertook whole-exome sequencing of 50 tumours from patients undergoing surgical resect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6a0ef2c310430fab98e5eaf4115d6e
https://www.repository.cam.ac.uk/handle/1810/315744
https://www.repository.cam.ac.uk/handle/1810/315744
Autor:
Anssi Nurminen, Serafiina Jaatinen, Sinja Taavitsainen, Gunilla Högnäs, Tom Lesluyes, Naser Ansari-Pour, Teemu Tolonen, Kerstin Haase, Antti Koskenalho, Matti Kankainen, Juho Jasu, Hanna Rauhala, Jenni Kesäniemi, Tiia Nikupaavola, Paula Kujala, Irina Rinta-Kiikka, Jarno Riikonen, Antti Kaipia, Teemu Murtola, Teuvo L. Tammela, Tapio Visakorpi, Matti Nykter, David C. Wedge, Peter Van Loo, G. Steven Bova
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Prostate cancer (PrCa) genomic heterogeneity causes resistance to therapies such as androgen deprivation. Such heterogeneity can be deciphered in the context of evolutionary principles, but current clinical trials do not include e
Externí odkaz:
https://doaj.org/article/7808b5d0d78d41449b9f048d30c6fc39
Autor:
Thomas B K Watkins, Emma C Colliver, Matthew R Huska, Tom L Kaufmann, Emilia L Lim, Cody B Duncan, Kerstin Haase, Peter Van Loo, Charles Swanton, Nicholas McGranahan, Roland F Schwarz
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 10, p e1011379 (2023)
Most computational methods that infer somatic copy number alterations (SCNAs) from bulk sequencing of DNA analyse tumour samples individually. However, the sequencing of multiple tumour samples from a patient's disease is an increasingly common pract
Externí odkaz:
https://doaj.org/article/813504d2d9cb4d0b820b2c0d5e22969e
Autor:
Elias Rodriguez-Fos, Mercè Planas-Fèlix, Martin Burkert, Montserrat Puiggròs, Joern Toedling, Nina Thiessen, Eric Blanc, Annabell Szymansky, Falk Hertwig, Naveed Ishaque, Dieter Beule, David Torrents, Angelika Eggert, Richard P. Koche, Roland F. Schwarz, Kerstin Haase, Johannes H. Schulte, Anton G. Henssen
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100402- (2023)
Summary: Neuroblastoma is a pediatric solid tumor characterized by strong clinical heterogeneity. Although clinical risk-defining genomic alterations exist in neuroblastomas, the mutational processes involved in their generation remain largely unclea
Externí odkaz:
https://doaj.org/article/0df526825af642e280ef874891c577b1
Autor:
Kerstin Haas, Jürgen Mottok
Publikováno v:
Advances in Intelligent Systems and Computing ISBN: 9783319732091
Research-oriented learning provides students the opportunity to develop their research competences by experiencing research practice, this often happens in the surrounding of research associations with different universities and companies. This paper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1495d729d172faf56ecb6407f024d874
https://doi.org/10.1007/978-3-319-73210-7_81
https://doi.org/10.1007/978-3-319-73210-7_81
Autor:
Jürgen Mottok, Kerstin Haas
Publikováno v:
EDULEARN proceedings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3209c8dffb82ca3e9bac16e70cfa28c5
https://doi.org/10.21125/edulearn.2017.0872
https://doi.org/10.21125/edulearn.2017.0872
Autor:
Tom L. Kaufmann, Marina Petkovic, Thomas B. K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi, Roland F. Schwarz
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-27 (2022)
Abstract Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide information for the complex task of phylogenetic inference. We present MEDICC2, a method for
Externí odkaz:
https://doaj.org/article/e4b330fa56874857bbfdc7ede9300d31
Autor:
Heathcliff Dorado García, Fabian Pusch, Yi Bei, Jennifer von Stebut, Glorymar Ibáñez, Kristina Guillan, Koshi Imami, Dennis Gürgen, Jana Rolff, Konstantin Helmsauer, Stephanie Meyer-Liesener, Natalie Timme, Victor Bardinet, Rocío Chamorro González, Ian C. MacArthur, Celine Y. Chen, Joachim Schulz, Antje M. Wengner, Christian Furth, Birgit Lala, Angelika Eggert, Georg Seifert, Patrick Hundsoerfer, Marieluise Kirchner, Philipp Mertins, Matthias Selbach, Andrej Lissat, Frank Dubois, David Horst, Johannes H. Schulte, Simone Spuler, Daoqi You, Filemon Dela Cruz, Andrew L. Kung, Kerstin Haase, Michela DiVirgilio, Monika Scheer, Michael V. Ortiz, Anton G. Henssen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Alveolar rhabdomyosarcoma is a clinically challenging disease due to the lack of druggable targets. Here the authors show preclinical evidence for ATR inhibitors as a therapeutic option for alveolar rhabdomyosarcoma.
Externí odkaz:
https://doaj.org/article/7544d8ec795c4dae8babbe7a0a303edd
Autor:
Karin Schmelz, Joern Toedling, Matt Huska, Maja C. Cwikla, Louisa-Marie Kruetzfeldt, Jutta Proba, Peter F. Ambros, Inge M. Ambros, Sengül Boral, Marco Lodrini, Celine Y. Chen, Martin Burkert, Dennis Guergen, Annabell Szymansky, Kathy Astrahantseff, Annette Kuenkele, Kerstin Haase, Matthias Fischer, Hedwig E. Deubzer, Falk Hertwig, Patrick Hundsdoerfer, Anton G. Henssen, Roland F. Schwarz, Johannes H. Schulte, Angelika Eggert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Neuroblastoma is a devastating tumour in children. Here, the authors analyse multi-region patient samples using genomics and transcriptomics, revealing temporal and spatial heterogeneity and questioning the reliability of single-biopsy based diagnost
Externí odkaz:
https://doaj.org/article/2390ab09b04a41c28245bac3ed08f2c9