Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Kerstin Hünniger"'
Autor:
Antje Häder, Sascha Schäuble, Jan Gehlen, Nadja Thielemann, Benedikt C. Buerfent, Vitalia Schüller, Timo Hess, Thomas Wolf, Julia Schröder, Michael Weber, Kerstin Hünniger, Jürgen Löffler, Slavena Vylkova, Gianni Panagiotou, Johannes Schumacher, Oliver Kurzai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait loci (eQTLs) and transcriptomes of monocytes from 215 individuals stimulated by fungal, Gram-negative or Gram-positive bacterial pathogens. We identify
Externí odkaz:
https://doaj.org/article/2cf885178e8843868db0af93d72f7768
Autor:
Ivan Belyaev, Alessandra Marolda, Jan-Philipp Praetorius, Arjun Sarkar, Anna Medyukhina, Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2297-2308 (2022)
Rapid identification of pathogens is required for early diagnosis and treatment of life-threatening bloodstream infections in humans. This requirement is driving the current developments of molecular diagnostic tools identifying pathogens from human
Externí odkaz:
https://doaj.org/article/daee8fdced5243888f8df60b2a584dbb
Ex vivo immune profiling in patient blood enables quantification of innate immune effector functions
Autor:
Teresa Lehnert, Ines Leonhardt, Sandra Timme, Daniel Thomas-Rüddel, Frank Bloos, Christoph Sponholz, Oliver Kurzai, Marc Thilo Figge, Kerstin Hünniger
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The assessment of a patient’s immune function is critical in many clinical situations. In complex clinical immune dysfunction like sepsis, which results from a loss of immune homeostasis due to microbial infection, a plethora of pro- and a
Externí odkaz:
https://doaj.org/article/44e5ddd83d8842ec9aabf80b07ef38dc
Autor:
Beeke Tappe, Chris D. Lauruschkat, Lea Strobel, Jezreel Pantaleón García, Oliver Kurzai, Silke Rebhan, Sabrina Kraus, Elena Pfeuffer-Jovic, Lydia Bussemer, Lotte Possler, Matthias Held, Kerstin Hünniger, Olaf Kniemeyer, Sascha Schäuble, Axel A. Brakhage, Gianni Panagiotou, P. Lewis White, Hermann Einsele, Jürgen Löffler, Sebastian Wurster
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Patients suffering from coronavirus disease-2019 (COVID-19) are susceptible to deadly secondary fungal infections such as COVID-19-associated pulmonary aspergillosis and COVID-19-associated mucormycosis. Despite this clinical observation, direct expe
Externí odkaz:
https://doaj.org/article/d722827bb9fc46acb787b360a554ab51
Autor:
Silke Machata, Sravya Sreekantapuram, Kerstin Hünniger, Oliver Kurzai, Christine Dunker, Katja Schubert, Wibke Krüger, Bianca Schulze-Richter, Cornelia Speth, Günter Rambach, Ilse D. Jacobsen
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Murine infection models are widely used to study systemic candidiasis caused by C. albicans. Whole-blood models can help to elucidate host-pathogens interactions and have been used for several Candida species in human blood. We adapted the human whol
Externí odkaz:
https://doaj.org/article/c1ca1de9ff614e508fb95416a7ce81ba
Autor:
Teresa Lehnert, Maria T E Prauße, Kerstin Hünniger, Jan-Philipp Praetorius, Oliver Kurzai, Marc Thilo Figge
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249372 (2021)
Computer simulations of mathematical models open up the possibility of assessing hypotheses generated by experiments on pathogen immune evasion in human whole-blood infection assays. We apply an interdisciplinary systems biology approach in which vir
Externí odkaz:
https://doaj.org/article/eb5f616ccbdf4c54a4d58279f443b7d1
Autor:
Philipp Kämmer, Sylvie McNamara, Thomas Wolf, Theresia Conrad, Stefanie Allert, Franziska Gerwien, Kerstin Hünniger, Oliver Kurzai, Reinhard Guthke, Bernhard Hube, Jörg Linde, Sascha Brunke
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Only four species, Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis, together account for about 90% of all Candida bloodstream infections and are among the most common causes of invasive fungal infections of humans. However,
Externí odkaz:
https://doaj.org/article/f2fe89eb2bd349eb97a5aea2719f38fa
Autor:
Esther Weiss, Jan Schlegel, Ulrich Terpitz, Michael Weber, Jörg Linde, Anna-Lena Schmitt, Kerstin Hünniger, Lothar Marischen, Florian Gamon, Joachim Bauer, Claudia Löffler, Oliver Kurzai, Charles Oliver Morton, Markus Sauer, Hermann Einsele, Juergen Loeffler
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Delayed natural killer (NK) cell reconstitution after allogeneic stem cell transplantation (alloSCT) is associated with a higher risk of developing invasive aspergillosis. The interaction of NK cells with the human pathogen Aspergillus (A.) fumigatus
Externí odkaz:
https://doaj.org/article/c83d94d16f584d25a9f56cbbca05603d
Autor:
Sophia Ruben, Enrico Garbe, Selene Mogavero, Daniela Albrecht-Eckardt, Daniela Hellwig, Antje Häder, Thomas Krüger, Katrin Gerth, Ilse D. Jacobsen, Osama Elshafee, Sascha Brunke, Kerstin Hünniger, Olaf Kniemeyer, Axel A. Brakhage, Joachim Morschhäuser, Bernhard Hube, Slavena Vylkova, Oliver Kurzai, Ronny Martin
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT The capacity of Candida albicans to reversibly change its morphology between yeast and filamentous stages is crucial for its virulence. Formation of hyphae correlates with the upregulation of genes ALS3 and ECE1, which are involved in pathog
Externí odkaz:
https://doaj.org/article/92ada380a5544ab2b0f537336c459272
Autor:
Vera Voltersen, Matthew G. Blango, Sahra Herrmann, Franziska Schmidt, Thorsten Heinekamp, Maria Strassburger, Thomas Krüger, Petra Bacher, Jasmin Lother, Esther Weiss, Kerstin Hünniger, Hong Liu, Peter Hortschansky, Alexander Scheffold, Jürgen Löffler, Sven Krappmann, Sandor Nietzsche, Oliver Kurzai, Hermann Einsele, Olaf Kniemeyer, Scott G. Filler, Utz Reichard, Axel A. Brakhage
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Aspergillus fumigatus is a common airborne fungal pathogen of humans and a significant source of mortality in immunocompromised individuals. Here, we provide the most extensive cell wall proteome profiling to date of A. fumigatus resting con
Externí odkaz:
https://doaj.org/article/9fe5a0ecbee347959685d1702c23f58a