Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kerstin Ehlert"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3215-3218
3-Substituted 6-anilinouracils, presently the most promising class of inhibitors of the bacterial DNA polymerase in Gram-positive bacteria, have been prepared by a general and straightforward three-step procedure starting from a readily available 1-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8e7875b85d2d5c59f82498a45e0e0c
https://doi.org/10.1016/j.bmcl.2008.04.061
https://doi.org/10.1016/j.bmcl.2008.04.061
Publikováno v:
Microbiology. 153:2093-2103
(-)-Epicatechin gallate (ECg), a component of green tea, sensitizes meticillin-resistant Staphylococcus aureus (MRSA) to beta-lactam antibiotics, promotes staphylococcal cell aggregation and increases cell-wall thickness. The potentiation of beta-lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a3f846f89560aaa6b1d6df16f7bb6e
https://doi.org/10.1099/mic.0.2007/007807-0
https://doi.org/10.1099/mic.0.2007/007807-0
Autor:
Dieter Haebich, Alexander Kuhl, Annegret Binas, Christoph Ladel, Karl Ziegelbauer, Michael Otteneder, Thomas Lampe, Helga Rübsamen-Waigmann, Niels Svenstrup, Michael Brands, Guido Schiffer, Kerstin Ehlert
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:987-995
Novel N-3-alkylated 6-anilinouracils have been identified as potent and selective inhibitors of bacterial DNA polymerase IIIC, the enzyme essential for the replication of chromosomal DNA in gram-positive bacteria. A nonradioactive assay measuring the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d40559aa3435c7b8cc728f45b324f8
https://doi.org/10.1128/aac.49.3.987-995.2005
https://doi.org/10.1128/aac.49.3.987-995.2005
Autor:
Brian J. Wilkinson, Jennifer L. Koehl, Arunachalam Muthaiyan, Harald Labischinski, Radheshyam K. Jayaswal, Kerstin Ehlert
Publikováno v:
Antimicrobial Agents and Chemotherapy. 48:3749-3757
The cell wall composition and autolytic properties of passage-selected glycopeptide-intermediate Staphylococcus aureus (GISA) isolates and their parent strains were studied in order to investigate the mechanism of decreased vancomycin susceptibility.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873decab11c75e903775eec108ada50e
https://doi.org/10.1128/aac.48.10.3749-3757.2004
https://doi.org/10.1128/aac.48.10.3749-3757.2004
Autor:
Ralph W. Jack, Kerstin Ehlert, Claudia Stößer, Gursharan S. Chhatwal, Kerstin Möller, Dieter J. Reinscheid, Bernhard J. Eikmanns
Publikováno v:
Microbiology. 148:3245-3254
Group B streptococcus (GBS) is surrounded by a capsule. However, little is known about peptidoglycan metabolism in these bacteria. In the present study, a 65 kDa protein was isolated from the culture supernatant of GBS and N-terminally sequenced, per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c89a400c63c19d9459df3577596d0eab
https://doi.org/10.1099/00221287-148-10-3245
https://doi.org/10.1099/00221287-148-10-3245
Autor:
Motoyuki Sugai, Kouji Ohta, Harald Labischinski, Hitoshi Komatsuzawa, Sakuo Yamada, Junko Kajimura, Tamaki Fujiwara, Kerstin Ehlert
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:75-81
The glycopeptide antibiotics vancomycin and teicoplanin are frequently used for the treatment of methicillin-resistant Staphylococcus aureus infections. Since the emergence of a clinically vancomycin-resistant S. aureus (VRSA) strain (strain Mu50) wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adb3f77f90d2eab3c4f94d802b96279
https://doi.org/10.1128/aac.46.1.75-81.2002
https://doi.org/10.1128/aac.46.1.75-81.2002
Publikováno v:
Antimicrobial Agents and Chemotherapy. 45:1431-1437
The potential for the development of resistance in oxacillin-resistantStaphylococcus aureus(ORSA) to lysostaphin, a glycylglycine endopeptidase produced byStaphylococcus simulansbiovarstaphylolyticus, was examined in vitro and in an in vivo model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b494f0317a261be63bd458abb86a6fb4
https://doi.org/10.1128/aac.45.5.1431-1437.2001
https://doi.org/10.1128/aac.45.5.1431-1437.2001
Publikováno v:
Molecular Microbiology. 16:761-768
Summary On the basis of the published N-terminal amino acid sequence of the soluble lytic transglycosylase 35 (Slt35) of Escherichia coli, an open reading frame (ORF) was cloned from the 60.8 min region of the E. coli chromosome. The nucleotide seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840b6b1f43d7a24fb6d002d53c529b67
https://doi.org/10.1111/j.1365-2958.1995.tb02437.x
https://doi.org/10.1111/j.1365-2958.1995.tb02437.x
Publikováno v:
ChemMedChem. 3(10)
The development of resistance has rendered several antibiotics clinically ineffective, and there is an urgent medical need for potent and safe antibacterials with a novel and valid mode of action. To avoid cross-resistance, they should preferably inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65db32985b1c1fc3847e1e25701f6e53
https://pubmed.ncbi.nlm.nih.gov/18792034
https://pubmed.ncbi.nlm.nih.gov/18792034
Publikováno v:
Expert opinion on investigational drugs. 7(8)
Many antimicrobial drugs have become less effective at combating infectious diseases, and experts in the field are concerned about the possibility of a ‘post-antibiotic era’ for some clinically important pathogens, particularly staphylococci. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f211d128b81b9fdce97261fd1b8e77
https://pubmed.ncbi.nlm.nih.gov/15992028
https://pubmed.ncbi.nlm.nih.gov/15992028