Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Kerstin Borgmann"'
Autor:
Marie Vogt, Sandra Classen, Ann Kristin Krause, Nadja-Juanita Peter, Cordula Petersen, Kai Rothkamm, Kerstin Borgmann, Felix Meyer
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 762 (2024)
The ubiquitin specific protease 7 (USP7) is a deubiquitinating enzyme with numerous substrates. Aberrant expression of USP7 is associated with tumor progression. This study aims to investigate how a deregulated USP7 expression affects chromosomal ins
Externí odkaz:
https://doaj.org/article/87a1cedc242645c9bed4b15f52ce9c47
Autor:
Joanna Kempska, Leticia Oliveira-Ferrer, Astrid Grottke, Minyue Qi, Malik Alawi, Felix Meyer, Kerstin Borgmann, Fabienne Hamester, Kathrin Eylmann, Maila Rossberg, Daniel J. Smit, Manfred Jücker, Elena Laakmann, Isabell Witzel, Barbara Schmalfeldt, Volkmar Müller, Karen Legler
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe PI3K/AKT pathway is activated in 43-70% of breast cancer (BC)-patients and promotes the metastatic potential of BC cells by increasing cell proliferation, invasion and radioresistance. Therefore, AKT1-inhibition in combination with ra
Externí odkaz:
https://doaj.org/article/7882ba2141484a4e949b72c38b608411
Autor:
Simon Gehre, Felix Meyer, Azzaya Sengedorj, Fridolin Grottker, Clara M. Reichardt, Jannik Alomo, Kerstin Borgmann, Benjamin Frey, Rainer Fietkau, Michael Rückert, Udo S. Gaipl
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Only a subset of patients with triple-negative breast cancer (TNBC) benefits from a combination of radio- (RT) and immunotherapy. Therefore, we aimed to examine the impact of radioresistance and brain metastasizing potential on the immunological phen
Externí odkaz:
https://doaj.org/article/2c3daa9acc1c4ab1be80ebca2d3caa0b
Autor:
Tara Al Zubaidi, O. H. Fiete Gehrisch, Marie-Michelle Genois, Qi Liu, Shan Lu, Jong Kung, Yunhe Xie, Jan Schuemann, Hsiao-Ming Lu, Aaron N. Hata, Lee Zou, Kerstin Borgmann, Henning Willers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Mutant KRAS is a common tumor driver and frequently confers resistance to anti-cancer treatments such as radiation. DNA replication stress in these tumors may constitute a therapeutic liability but is poorly understood. Here, using single-mo
Externí odkaz:
https://doaj.org/article/c9f65698ab184d44a3f15db972aba8ea
Autor:
Felix Meyer, Anna Maria Engel, Ann Kristin Krause, Tim Wagner, Lena Poole, Anna Dubrovska, Claudia Peitzsch, Kai Rothkamm, Cordula Petersen, Kerstin Borgmann
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cancer stem cells (CSCs) are a major cause of tumor therapy failure. This is mainly attributed to increased DNA repair capacity and immune escape. Recent studies have shown that functional DNA repair via homologous recombination (HR) prevents radiati
Externí odkaz:
https://doaj.org/article/fdb2d8df0fc941a283280939b46c8565
Publikováno v:
Cancers, Vol 15, Iss 1, p 211 (2022)
Breast cancer is the most diagnosed cancer in women, and symptomatic brain metastases (BCBMs) occur in 15–20% of metastatic breast cancer cases. Despite technological advances in radiation therapy (RT), the prognosis of patients is limited. This ha
Externí odkaz:
https://doaj.org/article/e5de3a6a707a47608038473c2017a0c7
Autor:
Sandra Classen, Elena Rahlf, Johannes Jungwirth, Nina Albers, Luca Philipp Hebestreit, Alexandra Zielinski, Lena Poole, Marco Groth, Philipp Koch, Thomas Liehr, Stefanie Kankel, Nils Cordes, Cordula Petersen, Kai Rothkamm, Helmut Pospiech, Kerstin Borgmann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13363 (2022)
BRCA1 is a well-known breast cancer risk gene, involved in DNA damage repair via homologous recombination (HR) and replication fork protection. Therapy resistance was linked to loss and amplification of the BRCA1 gene causing inferior survival of bre
Externí odkaz:
https://doaj.org/article/2dbe15c5a79049cb958da09e7ac76e0b
Autor:
Carlotta Riebensahm, Simon A. Joosse, Malte Mohme, Annkathrin Hanssen, Jakob Matschke, Yvonne Goy, Isabell Witzel, Katrin Lamszus, Jolanthe Kropidlowski, Cordula Petersen, Anja Kolb-Kokocinski, Sascha Sauer, Kerstin Borgmann, Markus Glatzel, Volkmar Müller, Manfred Westphal, Sabine Riethdorf, Klaus Pantel, Harriet Wikman
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-11 (2019)
Abstract Background The incidence of brain metastases in breast cancer (BCBM) patients is increasing. These patients have a very poor prognosis, and therefore, identification of blood-based biomarkers, such as circulating tumor cells (CTCs), and unde
Externí odkaz:
https://doaj.org/article/9ce323027a994649b8033de0443befc4
Autor:
Claudia Koch, Andra Kuske, Simon A Joosse, Gökhan Yigit, George Sflomos, Sonja Thaler, Daniel J Smit, Stefan Werner, Kerstin Borgmann, Sebastian Gärtner, Parinaz Mossahebi Mohammadi, Laura Battista, Laure Cayrefourcq, Janine Altmüller, Gabriela Salinas‐Riester, Kaamini Raithatha, Arne Zibat, Yvonne Goy, Leonie Ott, Kai Bartkowiak, Tuan Zea Tan, Qing Zhou, Michael R Speicher, Volkmar Müller, Tobias M Gorges, Manfred Jücker, Jean‐Paul Thiery, Cathrin Brisken, Sabine Riethdorf, Catherine Alix‐Panabières, Klaus Pantel
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp n/a-n/a (2020)
Abstract Functional studies giving insight into the biology of circulating tumor cells (CTCs) remain scarce due to the low frequency of CTCs and lack of appropriate models. Here, we describe the characterization of a novel CTC‐derived breast cancer
Externí odkaz:
https://doaj.org/article/6fcb45740e9c4955a376a11179160a9e
Autor:
Jacqueline Nathansen, Felix Meyer, Luise Müller, Marc Schmitz, Kerstin Borgmann, Anna Dubrovska
Publikováno v:
Cancers, Vol 13, Iss 19, p 4818 (2021)
Cancer stem cells (CSCs) are pluripotent and highly tumorigenic cells that can re-populate a tumor and cause relapses even after initially successful therapy. As with tissue stem cells, CSCs possess enhanced DNA repair mechanisms. An active DNA damag
Externí odkaz:
https://doaj.org/article/9b4f644b7abe4b0faf366516c5406686