Noise-induced cochlear synaptopathy in C57BL/6 N mice as a function of trauma strength: ribbons are more vulnerable than postsynapses

Autor: Kerstin Blum, Pauline Schepsky, Philip Derleder, Philipp Schätzle, Fahmi Nasri, Philipp Fischer, Jutta Engel, Simone Kurt

Publikováno v: Frontiers in Cellular Neuroscience, Vol 18 (2024)

Noise-induced cochlear synaptopathy is characterized by irreversible loss of synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) despite normal hearing thresholds. We analyzed hearing performance and cochlear structure in C57B

Externí odkaz: https://doaj.org/article/d56b50c7176e46b29ec9f9e219a19f7b

Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets

Autor: Mandy Sonntag, Maren Blosa, Sophie Schmidt, Katja Reimann, Kerstin Blum, Tobias Eckrich, Gudrun Seeger, Dietmar Hecker, Bernhard Schick, Thomas Arendt, Jutta Engel, Markus Morawski

Publikováno v: BMC Biology, Vol 16, Iss 1, Pp 1-18 (2018)

Abstract Background Perineuronal nets (PNNs) are specialized aggregations of extracellular matrix (ECM) molecules surrounding specific neurons in the central nervous system (CNS). PNNs are supposed to control synaptic transmission and are frequently

Externí odkaz: https://doaj.org/article/0cbf0673ed574acb9e63b8c16b5b13fa

Cochlea-Specific Deletion of Cav1.3 Calcium Channels Arrests Inner Hair Cell Differentiation and Unravels Pitfalls of Conditional Mouse Models

Autor: Stephanie Eckrich, Dietmar Hecker, Katharina Sorg, Kerstin Blum, Kerstin Fischer, Stefan Münkner, Gentiana Wenzel, Bernhard Schick, Jutta Engel

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)

Inner hair cell (IHC) Cav1.3 Ca2+ channels are multifunctional channels mediating Ca2+ influx for exocytosis at ribbon synapses, the generation of Ca2+ action potentials in pre-hearing IHCs and gene expression. IHCs of deaf systemic Cav1.3-deficient

Externí odkaz: https://doaj.org/article/f2ebd11783264bceb66d34f31439d70f

Integrated primary care in Germany: the road ahead

Autor: Sophia Schlette, Melanie Lisac, Kerstin Blum

Publikováno v: International Journal of Integrated Care, Vol 9, Iss 2 (2009)

Problem statement: Health care delivery in Germany is highly fragmented, resulting in poor vertical and horizontal integration and a system that is focused on curing acute illness or single diseases instead of managing patients with more complex or c

Externí odkaz: https://doaj.org/article/e2f74b5f90d14aedb755c3f9c2d96f60

What Causes the Dependency between Perceived Aesthetics and Perceived Usability?

Autor: Jörg Thomaschewski, Raphael Otten, Kerstin Blum, Martin Schrepp

Publikováno v: International Journal of Interactive Multimedia and Artificial Intelligence, Vol 6, Iss 6, Pp 78-85 (2021)
Re-Unir. Archivo Institucional de la Universidad Internacional de La Rioja
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Several studies reported a dependency between perceived beauty and perceived usability of a user interface. But it is still not fully clear which psychological mechanism is responsible for this dependency. We suggest a new explanation based on the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291028612b0896a2452e345903975e70
https://www.ijimai.org/journal/bibcite/reference/2872