Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Kerstin B. Kaufmann"'
Autor:
Winnie L. Kan, Urmi Dhagat, Kerstin B. Kaufmann, Timothy R. Hercus, Tracy L. Nero, Andy GX. Zeng, John Toubia, Emma F. Barry, Sophie E. Broughton, Guillermo A. Gomez, Brooks A. Benard, Mara Dottore, Karen S. Cheung Tung Shing, Helena Boutzen, Saumya E. Samaraweera, Kaylene J. Simpson, Liqing Jin, Gregory J. Goodall, C. Glenn Begley, Daniel Thomas, Paul G. Ekert, Denis Tvorogov, Richard J. D'Andrea, John E. Dick, Michael W. Parker, Angel F. Lopez
Publikováno v:
Cancer Discovery.
Leukemia stem cells (LSC) possess distinct self-renewal and arrested differentiation properties that are responsible for disease emergence, therapy failure and recurrence in acute myeloid leukemia (AML). Despite AML displaying extensive biological an
Autor:
Geethu Emily Thomas, Grace Egan, Laura García-Prat, Aaron Botham, Veronique Voisin, Parasvi S. Patel, Fieke W. Hoff, Jordan Chin, Boaz Nachmias, Kerstin B. Kaufmann, Dilshad H. Khan, Rose Hurren, Xiaoming Wang, Marcela Gronda, Neil MacLean, Cristiana O’Brien, Rashim P. Singh, Courtney L. Jones, Shane M. Harding, Brian Raught, Andrea Arruda, Mark D. Minden, Gary D. Bader, Razq Hakem, Steve Kornblau, John E. Dick, Aaron D. Schimmer
Publikováno v:
Nature Cell Biology, 24(6), 872-884. Nature Publishing Group
Thomas, Egan et al. report that hexokinase 2 localizes to the nucleus of leukaemic and normal haematopoietic cells to maintain stemness by interacting with nuclear proteins and modulating chromatin accessibility independently of its kinase activity.M
Autor:
John E. Dick, Mark D. Minden, Timm Schroeder, Chiara Luberto, Yusuf A. Hannun, Jean C.Y. Wang, Gary D. Bader, Veronique Voisin, Yang Zhang, Gareth Holmes, Joseph Jargstorf, Melissa Kleinau, Héléna Boutzen, Qiang Liu, James A. Kennedy, Amanda Mitchell, Elvin Wagenblast, Jessica McLeod, Liqing Jin, Andy G.X. Zeng, ChangJiang Xu, Stanley W.K. Ng, Shin-ichiro Takayanagi, Laura Garcia-Prat, Elisa Laurenti, Olga I. Gan, Michelle Chan-Seng-Yue, Weijia Wang, Kerstin B. Kaufmann, Stephanie Z. Xie
Supplemental Movie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d025d58e392c34a88c50b6d131c715e
https://doi.org/10.1158/2643-3230.22542151
https://doi.org/10.1158/2643-3230.22542151
Autor:
John E. Dick, Mark D. Minden, Timm Schroeder, Chiara Luberto, Yusuf A. Hannun, Jean C.Y. Wang, Gary D. Bader, Veronique Voisin, Yang Zhang, Gareth Holmes, Joseph Jargstorf, Melissa Kleinau, Héléna Boutzen, Qiang Liu, James A. Kennedy, Amanda Mitchell, Elvin Wagenblast, Jessica McLeod, Liqing Jin, Andy G.X. Zeng, ChangJiang Xu, Stanley W.K. Ng, Shin-ichiro Takayanagi, Laura Garcia-Prat, Elisa Laurenti, Olga I. Gan, Michelle Chan-Seng-Yue, Weijia Wang, Kerstin B. Kaufmann, Stephanie Z. Xie
Figure S1 to S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1222fc32e518523765292a642027a26e
https://doi.org/10.1158/2643-3230.22542139
https://doi.org/10.1158/2643-3230.22542139
Autor:
John E. Dick, Mark D. Minden, Timm Schroeder, Chiara Luberto, Yusuf A. Hannun, Jean C.Y. Wang, Gary D. Bader, Veronique Voisin, Yang Zhang, Gareth Holmes, Joseph Jargstorf, Melissa Kleinau, Héléna Boutzen, Qiang Liu, James A. Kennedy, Amanda Mitchell, Elvin Wagenblast, Jessica McLeod, Liqing Jin, Andy G.X. Zeng, ChangJiang Xu, Stanley W.K. Ng, Shin-ichiro Takayanagi, Laura Garcia-Prat, Elisa Laurenti, Olga I. Gan, Michelle Chan-Seng-Yue, Weijia Wang, Kerstin B. Kaufmann, Stephanie Z. Xie
Supplementary tables 1 to 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b65df25d4831768670290c1ed7781e6
https://doi.org/10.1158/2643-3230.22542145.v1
https://doi.org/10.1158/2643-3230.22542145.v1
Autor:
John E. Dick, Mark D. Minden, Timm Schroeder, Chiara Luberto, Yusuf A. Hannun, Jean C.Y. Wang, Gary D. Bader, Veronique Voisin, Yang Zhang, Gareth Holmes, Joseph Jargstorf, Melissa Kleinau, Héléna Boutzen, Qiang Liu, James A. Kennedy, Amanda Mitchell, Elvin Wagenblast, Jessica McLeod, Liqing Jin, Andy G.X. Zeng, ChangJiang Xu, Stanley W.K. Ng, Shin-ichiro Takayanagi, Laura Garcia-Prat, Elisa Laurenti, Olga I. Gan, Michelle Chan-Seng-Yue, Weijia Wang, Kerstin B. Kaufmann, Stephanie Z. Xie
Acute myeloid leukemia (AML) is a caricature of normal hematopoiesis driven from leukemia stem cells (LSC) that share some hematopoietic stem cell (HSC) programs including responsiveness to inflammatory signaling. Although inflammation dysregulates m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f669fc934cf802690e8832e1eb652b
https://doi.org/10.1158/2643-3230.c.6549814
https://doi.org/10.1158/2643-3230.c.6549814
Autor:
Carys S. Johnson, Kendig Sham, Serena Belluschi, Xiaonan Wang, Winnie Lau, Kerstin B. Kaufmann, Gabriela Krivdova, Emily F. Calderbank, Nicole Mende, Jessica McLeod, Giovanna Mantica, Matthew J. Williams, Charlotte Grey-Wilson, Michael Drakopoulos, Shubhankar Sinha, Evangelia Diamanti, Christina Basford, Anthony R. Green, Nicola K. Wilson, Steven J. Howe, John E. Dick, Bertie Göttgens, Natalie Francis, Elisa Laurenti
Loss of long-term haematopoietic stem cell function (LT-HSC) hampers the success ofex vivoHSC gene therapy and expansion procedures, but the kinetics and the mechanisms by which this occurs remain incompletely characterized. Here through time-resolve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d30ea449c3cf6457e4ebfe0569ef3fb6
https://doi.org/10.1101/2022.11.17.516906
https://doi.org/10.1101/2022.11.17.516906
Autor:
Etienne Coyaud, Rahul Satija, Michelle Chan-Seng-Yue, John E. Dick, Héléna Boutzen, Alex Murison, Shin ichiro Takayanagi, Kerstin B. Kaufmann, Laura García-Prat, Andy G.X. Zeng, Kristele Pan, Olga I. Gan, Estelle M.N. Laurent, Sasan Zandi, Stephanie Z. Xie, Brian Raught, Jessica McLeod, Efthymia Papalexi
Publikováno v:
Nature Immunology
Nature Immunology, 2021, Nature Immunology, 22, pp.723-734. ⟨10.1038/s41590-021-00925-1⟩
Nature Immunology, 2021, Nature Immunology, 22, pp.723-734. ⟨10.1038/s41590-021-00925-1⟩
Continuous supply of immune cells throughout life relies on the delicate balance in the hematopoietic stem cell (HSC) pool between long-term maintenance and meeting the demands of both normal blood production and unexpected stress conditions. Here we
Autor:
Héléna Boutzen, Seyed Ali Madani Tonekaboni, Michelle Chan-Seng-Yue, Alex Murison, Naoya Takayama, Nathan Mbong, Elvin Wagenblast, Elias Orouji, Andrea Arruda, Amanda Mitchell, Faiyaz Notta, Mark D. Minden, Mathieu Lupien, Kerstin B. Kaufmann, John E. Dick
Publikováno v:
Leukemia. 36(11)
Many cancers are organized as cellular hierarchies sustained by cancer stem cells (CSC), whose eradication is crucial for achieving long-term remission. Difficulties to isolate and undertake in vitro and in vivo experimental studies of rare CSC under
Autor:
Héléna Boutzen, Michelle Chan-Seng-Yue, Alex Murison, Nathan Mbong, Elvin Wagenblast, Christopher Arlidge, Seyed Ali Madani Tonekaboni, Elias Orouji, Andrea Arruda, Amanda Mitchell, Faiyaz Notta, Mathieu Lupien, Mark D. Minden, Kerstin B. Kaufmann, John E. Dick
The ability of leukemic stem cells (LSC) to evade therapy and fuel leukemic progression causing relapse impedes therapeutic success in acute myeloid leukemia (AML). The LSC pool within a patient sample is not homogenous but comprises distinct LSC sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee169d9e7566582465949abdefe3637b
https://doi.org/10.1101/2022.03.01.482535
https://doi.org/10.1101/2022.03.01.482535