Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kerstin A. Hagenfeldt"'
Autor:
Peter A. Antinozzi, Haiyan Wang, Pierre Maechler, Anneli Björklund, Kerstin A. Hagenfeldt-Johansson, Laura Herrero, Claes B. Wollheim
Publikováno v:
Journal of Biological Chemistry. 278:16622-16629
Accumulation of lipids in non-adipose tissues is often associated with Type 2 diabetes and its complications. Elevated expression of the lipogenic transcription factor, sterol regulatory element binding protein-1c (SREBP-1c), has been demonstrated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc96d6975a679b06db04750bb1520f07
https://doi.org/10.1074/jbc.m212488200
https://doi.org/10.1074/jbc.m212488200
Autor:
Benoit R. Gauthier, Luc A. Otten, Haiyan Wang, Kerstin A. Hagenfeldt-Johansson, Pedro Luis Herrera, Claes B. Wollheim
Publikováno v:
Diabetes, Vol. 51, No Suppl 3 (2002) pp. S333-342
Six monogenic forms of maturity-onset diabetes of the young (MODY) have been identified to date. Except for MODY2 (glucokinase), all other MODY subtypes have been linked to transcription factors. We have established a MODY3 transgenic model through t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb7e7b3c41e79040e473da77d5547e2
https://doi.org/10.2337/diabetes.51.2007.s333
https://doi.org/10.2337/diabetes.51.2007.s333
Autor:
Haiyan Wang, Beate Ritz-Laser, Claes B. Wollheim, Hisamitsu Ishihara, Kerstin A. Hagenfeldt, Jacques Philippe, Pierre Maechler
Publikováno v:
Journal of Biological Chemistry, Vol. 276, No 27 (2001) pp. 25279-86
The absence of Pdx1 and the expression of brain-4 distinguish alpha-cells from other pancreatic endocrine cell lineages. To define the transcription factor responsible for pancreatic cell differentiation, we employed the reverse tetracycline-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8762477d178f25d36062de96ed9eff22
https://doi.org/10.1074/jbc.m101233200
https://doi.org/10.1074/jbc.m101233200
Publikováno v:
The EMBO Journal. 19:4257-4264
The reverse tetracycline-dependent transactivator system was employed in insulinoma INS-1 cells to achieve controlled inducible expression of hepatocyte nuclear factor-1 alpha (HNF1 alpha)-P291fsinsC, the most common mutation associated with subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de105173f6834f205c9dcf17eda977fa
https://doi.org/10.1093/emboj/19.16.4257
https://doi.org/10.1093/emboj/19.16.4257
Autor:
Benoit R. Gauthier, Haiyan Wang, Claes B. Wollheim, Mariella Iezzi, Kerstin A. Hagenfeldt-Johansson
Publikováno v:
Journal of Biological Chemistry, Vol. 277, No 20 (2002) pp. 17564-70
The transcription factor Foxa2 is implicated in blood glucose homeostasis. Conditional expression of Foxa2 or its dominant-negative mutant DN-Foxa2 in INS-1 cells reveals that Foxa2 regulates the expression of genes important for glucose sensing in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71aa8aca0492aeafc48c72248b80a537
https://archive-ouverte.unige.ch/unige:34554
https://archive-ouverte.unige.ch/unige:34554
Autor:
Kerstin A. Hagenfeldt-Johansson, Asllan Gjinovci, Haiyan Wang, Claes B. Wollheim, Pedro Luis Herrera, Hisamitsu Ishihara
Publikováno v:
Endocrinology, Vol. 142, No 12 (2001) pp. 5311-5320
Mutations in the transcription factor hepatocyte nuclear factor-1 alpha (HNF-1 alpha) cause maturity-onset diabetes of the young 3, a severe form of diabetes characterized by pancreatic beta-cell dysfunction. We have used targeted expression of a dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b6d1f95654642d2fe090bda26d27b1
https://pubmed.ncbi.nlm.nih.gov/11713231
https://pubmed.ncbi.nlm.nih.gov/11713231
Publikováno v:
Journal of Biological Chemistry, Vol. 275, No 46 (2000) pp. 35953-9
Mutations in the HNF4alpha gene are associated with the subtype 1 of maturity-onset diabetes of the young (MODY1), which is characterized by impaired insulin secretory response to glucose in pancreatic beta-cells. Hepatocyte nuclear factor 4alpha (HN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc9477a9eb0b1bad40d29770b7bb115
https://archive-ouverte.unige.ch/unige:35181
https://archive-ouverte.unige.ch/unige:35181
Publikováno v:
EMBO Journal, Vol. 17, No 22 (1998) pp. 6701-13
Mutations in the hepatocyte nuclear factor-1alpha (HNF-1alpha) have been linked to subtype 3 of maturity-onset diabetes of the young (MODY3), which is characterized by a primary defect in insulin secretion. The role of HNF-1alpha in the regulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188c94f2e9675e8bf7d6a329dc08eed4
https://pubmed.ncbi.nlm.nih.gov/9822613
https://pubmed.ncbi.nlm.nih.gov/9822613