Preclinical and first-in-human safety studies on a novel magnetism-based haemofiltration method

Autor: Nicole Waalders, Dirk van Lier, Jelle Gerretsen, Lucy Moran, Kerstin A. Stegmann, Will Twigger, Cristina Blanco-Andujar, George Frodsham, Matthijs Kox, Peter Pickkers

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Abstract Extracorporeal haemofiltration devices that selectively remove cytokines could represent an adjunctive treatment in inflammatory diseases. One such device is the “IL-6-Sieve”, wherein magnetic Anti-IL-6 Beads are introduced into an extra

Externí odkaz: https://doaj.org/article/15641466c67f457e8b1d51dc901564a2

CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity

Autor: Roland Preece, Andrea Pavesi, Soragia Athina Gkazi, Kerstin A. Stegmann, Christos Georgiadis, Zhi Ming Tan, Jia Ying Joey Aw, Mala K. Maini, Antonio Bertoletti, Waseem Qasim

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 149-161 (2020)

Emerging base editing technology exploits CRISPR RNA-guided DNA modification effects for highly specific C > T conversion, which has been used to efficiently disrupt gene expression. These tools can enhance synthetic T cell immunity by restricting sp

Externí odkaz: https://doaj.org/article/00ec11294bb54f618d18c76675005e30

Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence

Autor: Leo Swadling, Laura J. Pallett, Mariana O. Diniz, Josephine M. Baker, Oliver E. Amin, Kerstin A. Stegmann, Alice R. Burton, Nathalie M. Schmidt, Anna Jeffery-Smith, Nekisa Zakeri, Kornelija Suveizdyte, Farid Froghi, Giuseppe Fusai, William M. Rosenberg, Brian R. Davidson, Anna Schurich, A. Katharina Simon, Mala K. Maini

Publikováno v: Cell Reports, Vol 30, Iss 3, Pp 687-698.e6 (2020)

Summary: Tissue-resident memory T cells have critical roles in long-term pathogen and tumor immune surveillance in the liver. We investigate the role of autophagy in equipping human memory T cells to acquire tissue residence and maintain functionalit

Externí odkaz: https://doaj.org/article/424ef329fece490388a8227ae3fca83e

CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity

Autor: Antonio Bertoletti, Kerstin A. Stegmann, Soragia Athina Gkazi, Andrea Pavesi, Jia Ying Joey Aw, Zhi Ming Tan, Waseem Qasim, Mala K. Maini, Christos Georgiadis, Roland Preece

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 149-161 (2020)
Molecular Therapy. Methods & Clinical Development

Emerging base editing technology exploits CRISPR RNA-guided DNA modification effects for highly specific C > T conversion, which has been used to efficiently disrupt gene expression. These tools can enhance synthetic T cell immunity by restricting sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3992bcb314b53e93f2d695a96f721d6f
http://www.sciencedirect.com/science/article/pii/S232905012030187X

NK cells limit therapeutic vaccine–induced CD8+T cell immunity in a PD-L1–dependent manner

Autor: Mariana O. Diniz, Anna Schurich, Senthil K. Chinnakannan, Marion Duriez, Kerstin A. Stegmann, Jessica Davies, Stephanie Kucykowicz, Kornelija Suveizdyte, Oliver E. Amin, Frances Alcock, Tamsin Cargill, Eleanor Barnes, Mala K. Maini

Publikováno v: Diniz, M O, Schurich, A, Chinnakannan, S K, Duriez, M, Stegmann, K A, Davies, J, Kucykowicz, S, Suveizdyte, K, Amin, O E, Alcock, F, Cargill, T, Barnes, E & Maini, M K 2022, ' NK cells limit therapeutic vaccine–induced CD8 + T cell immunity in a PD-L1–dependent manner ', Science Translational Medicine, vol. 14, no. 640, eabi4670 . https://doi.org/10.1126/scitranslmed.abi4670

A better understanding of mechanisms that regulate CD8 + T cell responses to therapeutic vaccines is needed to develop approaches to enhance vaccine efficacy for chronic viral infections and cancers. We show here that NK cell depletion enhanced antig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8b8a4db370a666b93d46c902bd6ad2
https://kclpure.kcl.ac.uk/ws/files/175375334/NK_cells_limit_therapeutic_DINIZ_Publishedonline13April2022_GREEN_AAM.pdf