Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Kerstin Brüchner"'
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Akademický článek
An optimized small animal tumour model for experimentation with low energy protons.
Autor: Elke Beyreuther, Kerstin Brüchner, Mechthild Krause, Margret Schmidt, Rita Szabo, Jörg Pawelke
Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0177428 (2017)
BACKGROUND:The long-term aim of developing laser based particle acceleration towards clinical application requires not only substantial technological progress, but also the radiobiological characterization of the resulting ultra-short and ultra-inten
Externí odkaz: https://doaj.org/article/890686b35e5347debac8372d5169da9d
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2
First systematic in vivo tumor irradiation in mice with laser-accelerated and dose-homogenized proton beams from the Draco PW laser
Autor: Sebastian Meister, Florian Kroll, Marvin Reimold, Elisabeth Lessmann, Florian-Emanuel Brack, Josefine Metzkes-Ng, Ulrich Schramm, Jörg Pawelke, Karl Zeil, Kerstin Brüchner, Alexej Nossula, Leonhard Karsch, Stephan Kraft, Elisabeth Bodenstein, Marvin E. P. Umlandt, Elke Beyreuther, Jens Pietzsch
Publikováno v: Laser Acceleration of Electrons, Protons, and Ions VI.
After the rediscovery of the normal tissue sparing effect of high dose rate radiation, i.e. the so-called FLASH effect, by Favaudon et al. in 2014, research activities on this topic have been revived and are flourishing ever since. Yet, the exact bio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a301dac3ad4f3f64453f4b9f53dda69a
https://doi.org/10.1117/12.2589523
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3
Effect of [F-18]FMISO stratified dose-escalation on local control in FaDu hSCC in nude mice
Autor: Jörg Kotzerke, Christina Schütze, A. Yaromina, Franziska Hessel, Ralf Bergmann, Jörg Steinbach, Kerstin Brüchner, Daniel Zips, Bettina Beuthien-Baumann, Mechthild Krause, Birgit Mosch, Howard D. Thames, Michael Baumann
Publikováno v: Radiotherapy and Oncology, 111(1), 81-87. Elsevier Ireland Ltd
Objective To investigate the effect of radiation dose-escalation on local control in hypoxic versus non-hypoxic hypoxic tumours defined using [ 18 F]fluoromisonidazole ([ 18 F]FMISO) PET. Materials and methods FaDu human squamous cell carcinomas (hSC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c2630e6674c181c9d2c21a9321ad68
https://doi.org/10.1016/j.radonc.2014.02.005
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4
Impact of pre- and early per-treatment FDG-PET based dose-escalation on local tumour control in fractionated irradiated FaDu xenograft tumours
Autor: Esther G.C. Troost, Jörg Steinbach, Mechthild Krause, Kerstin Brüchner, Christina Jentsch, Steffen Löck, Ralf Bergmann, Ala Yaromina, Birgit Mosch, Daniel Zips, Jörg Kotzerke, Michael Baumann, Bettina Beuthien-Baumann, Howard D. Thames
Publikováno v: Radiotherapy and Oncology 121(2016)3, 447-452
Radiotherapy and Oncology, 121(3), 447-452. Elsevier Ireland Ltd
Objective: To investigate local tumour control after dose-escalation based on [18F]2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) obtained before and early during fractionated irradiation. Materials and methods: 85 mice bearing F
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca54c9ea04644f6d5097f4947d4cb1bd
https://www.hzdr.de/publications/Publ-25039-1
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5
Radiation‐induced variations in urothelial expression of intercellular adhesion molecule 1 (ICAM‐1): association with changes in urinary bladder function
Autor: J Jaal, Kerstin Brüchner, Wolfgang Dörr, C Hoinkis
Publikováno v: International Journal of Radiation Biology. 80:65-72
To assess the effect of single-dose irradiation on intercellular adhesion molecule 1 (ICAM-1) expression in the urothelium of mouse urinary bladder and to correlate ICAM-1 variations with fluctuations in storage capacity during the early and late rad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c67d2b703d16d6fd7c0a5257791e6f
https://doi.org/10.1080/09553000310001632921
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6
Selective inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS and the improvement of growth delay, but not local control, after fractionated irradiation in human FaDu squamous cell carcinoma in the nude mouse
Autor: Cordula Petersen, D. Zips, Michael H. Baumann, Wolfgang Eicheler, J. Ahrens, Mechthild Krause, Kerstin Brüchner, Frank Hilberg, Annegret Dörfler
Publikováno v: International Journal of Radiation Biology. 79:547-559
To investigate the effect of BIBX1382BS, an inhibitor of the epidermal growth factor receptor tyrosine kinase, on proliferation and clonogenic cell survival of FaDu human squamous cell carcinoma in vitro, and on tumour growth and local tumour control
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2788336b4a6b8d743c93bb155331ec
https://doi.org/10.1080/0955300031000112839
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8
Comparison study of in vivo dose response to laser-driven versus conventional electron beam
Autor: Leonhard Karsch, Maria Nicolai, Elisabeth Leßmann, Michael Schürer, Kerstin Brüchner, L. Laschinsky, Josefin Hartmann, Ralf Bergmann, Melanie Oppelt, Malte C. Kaluza, Maria Reuter, Elke Beyreuther, Michael Schnell, A. Sävert, Michael Baumann, Christian Richter, Jörg Pawelke, Julia Woithe, Mechthild Krause
Publikováno v: Radiation and environmental biophysics. 54(2)
The long-term goal to integrate laser-based particle accelerators into radiotherapy clinics not only requires technological development of high-intensity lasers and new techniques for beam detection and dose delivery, but also characterization of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cfb2dda47fdb178a5f0c1a4df0fe57
https://pubmed.ncbi.nlm.nih.gov/25600561
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9
Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation
Autor: Holger Hess-Stumpp, Kristin Gurtner, Daniel Zips, Michael Baumann, Lydia Koi, Martin Pruschy, L. Helbig, Kerstin Brüchner, Ala Yaromina, Kerstin Unterschemmann
Publikováno v: International Journal of Radiation Oncology Biology Physics 88(2014)1, 159-166
International Journal of Radiation Oncology Biology Physics, 88(1), 159-166. Elsevier Science
Purpose To study the effects of BAY-84-7296, a novel orally bioavailable inhibitor of mitochondrial complex I and hypoxia-inducible factor 1 (HIF-1) activity, on hypoxia, microenvironment, and radiation response of tumors. Methods and Materials UT-SC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd55344e50d6567a5952c95a4b1322a
https://www.hzdr.de/publications/Publ-19847-1
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10
Radiolabeled anti-EGFR-antibody improves local tumor control after external beam radiotherapy and offers theragnostic potential
Autor: Ralf Bergmann, Jörg Steinbach, Kerstin Brüchner, Hans-Jürgen Pietzsch, Mechthild Krause, Jens Pietzsch, Lydia Koi, Michael Baumann, Daniel Zips
Publikováno v: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 110(2)
Purpose The effect of radioimmunotherapy (RIT) using the therapeutic radionuclide Y-90 bound to the anti-EGFR antibody cetuximab combined with external beam irradiation (EBRT) (EBRIT) on permanent local tumor control in vivo was examined. Methods Gro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c1d1f86132367c3d3255e45abbe37e
https://pubmed.ncbi.nlm.nih.gov/24440046
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