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Preclinical evaluation of the maximum tolerated dose and toxicokinetics of enteric-coated lantibiotic OG253 capsules.

Autor: Rajeshkumar NV; Intrexon Corporation, Human Therapeutics Division, 20358 Seneca Meadows Pkwy, Germantown, MD 20876, USA., Kers JA; Intrexon Corporation, Industrial Products Division, 29 Oyster Point Blvd., South San Francisco, CA 94080, USA., Moncrief S; Intrexon Corporation, Human Therapeutics Division, 20358 Seneca Meadows Pkwy, Germantown, MD 20876, USA., Defusco AW; Oragenics, Inc., 13700 Progress Blvd., Alachua, FL 32608, USA., Park JH; Oragenics, Inc., 13700 Progress Blvd., Alachua, FL 32608, USA., Handfield M; Oragenics, Inc., 13700 Progress Blvd., Alachua, FL 32608, USA. Electronic address: mhandfield@oragenics.com.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2019 Jul 01; Vol. 374, pp. 32-40. Date of Electronic Publication: 2019 Apr 26.

Blueprints for the rational design of therapeutic mutacin 1140 variants.

Autor: Kers JA; Intrexon Corp., Industrial Products Division, South San Francisco, California., Sharp RE; Intrexon Corp., Industrial Products Division, South San Francisco, California., Muley S; Intrexon Corp., Industrial Products Division, South San Francisco, California., Mayo M; Intrexon Corp., Industrial Products Division, South San Francisco, California., Colbeck J; Intrexon Corp., Industrial Products Division, South San Francisco, California., Zhu Y; Intrexon Corp., Industrial Products Division, South San Francisco, California., DeFusco AW; Oragenics, Inc., Alachua, Florida., Park JH; Oragenics, Inc., Alachua, Florida., Handfield M; Oragenics, Inc., Alachua, Florida.

Publikováno v: Chemical biology & drug design [Chem Biol Drug Des] 2018 Dec; Vol. 92 (6), pp. 1940-1953. Date of Electronic Publication: 2018 Aug 18.

Mutacin 1140 Lantibiotic Variants Are Efficacious Against Clostridium difficile Infection.

Autor: Kers JA; Industrial Products Division, Intrexon Corp., South San Francisco, CA, United States., Sharp RE; Industrial Products Division, Intrexon Corp., South San Francisco, CA, United States., Defusco AW; Oragenics, Inc., Tampa, FL, United States., Park JH; Oragenics, Inc., Tampa, FL, United States., Xu J; Department of Chemistry, University of Massachusetts Lowell, Lowell, MA, United States., Pulse ME; PreClinical Services, UNT System College of Pharmacy, Fort Worth, TX, United States., Weiss WJ; PreClinical Services, UNT System College of Pharmacy, Fort Worth, TX, United States., Handfield M; Oragenics, Inc., Tampa, FL, United States.

Publikováno v: Frontiers in microbiology [Front Microbiol] 2018 Mar 16; Vol. 9, pp. 415. Date of Electronic Publication: 2018 Mar 16 (Print Publication: 2018).

Second-site suppression of RNase E essentiality by mutation of the deaD RNA helicase in Escherichia coli.

Autor: Tamura M; Department of Genetics, School of Medicine, Stanford University, Stanford, California, USA., Kers JA, Cohen SN

Publikováno v: Journal of bacteriology [J Bacteriol] 2012 Apr; Vol. 194 (8), pp. 1919-26. Date of Electronic Publication: 2012 Feb 10.