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Autor:
Paul Waring, Joy Hendley, Anne Thompson, Doris Germain, Kerry Warren, Renee Dow, Andreja Pirkmaier, Soula Ganiatsas
Publikováno v:
Oncogene. 22(28)
The three human D-type cyclins, cyclin D1, D2 and D3 share the ability to bind to and activate cdk4 and 6. MMTV-cyclin D1 transgenic mice develop mainly adenocarcinoma, while MMTV-cyclin D2 mice show a lack of alveologenesis during pregnancy and only