Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kerry T. Blanchard"'
Autor:
Warren W. Ku, Brian Knight, Kerry T. Blanchard, Susan Emeigh Hart, Susan van Tongeren, Dale E. Sharp, Matthew S. Bogdanffy, Robert Francis Stachlewitz
Publikováno v:
International Journal of Toxicology. 33:436-449
Empagliflozin, a selective inhibitor of the renal tubular sodium-glucose cotransporter 2, was developed for treatment of type 2 diabetes mellitus. Nonclinical safety of empagliflozin was studied in a battery of tests to support global market authoriz
Autor:
Edward Dere, Jeffrey S. Moffit, Daniel J. Spade, Kerry T. Blanchard, Susan J. Hall, James D. Smith, Aimee Altemus, Kim Boekelheide, Jonathan A. Phillips
Publikováno v:
Toxicology and applied pharmacology. 320
The human testis is sensitive to toxicant-induced injury but current methods for detecting adverse effects are limited, insensitive and unreliable. Animal studies use sensitive histopathological endpoints to assess toxicity, but require testicular ti
Autor:
J. Todd Auman, Kevin Gerrish, Kerry T. Blanchard, Qihong Huang, Richard S. Paules, Supriya Jayadev, Jeff W. Chou
Publikováno v:
Environmental Health Perspectives
Background Toxicogenomics experiments often reveal thousands of transcript alterations that are related to multiple processes, making it difficult to identify key gene changes that are related to the toxicity of interest. Objectives The objective of
Autor:
Nader Rifai, Helen V. Ratajczak, Eugene H. Herman, Raymond E. Stoll, Frank D. Sistare, Alan Knapton, Kerry T. Blanchard, Donald G. Robertson, Jun Zhang, Michael D. Reily, Ronald Honchel
Publikováno v:
Toxicologic Pathology. 34:152-163
The cardiovascular injury of the type III selective PDE inhibitor SK&F 95654 was investigated in SHR. Twenty-four hours after a single sc injection of 100 or 200 mg/kg of the drug, rats exhibited cardiomyocyte necrosis and apoptosis, interstitial inf
Autor:
Kerry T. Blanchard, Sylvia M. Furst, John H. Mennear, James H. Stoltz, J. B. Majeska, P. D. Lilly, R. E. Stoll
Publikováno v:
Toxicological Sciences. 90:440-450
Phenolphthalein (800 and 2400 mg/kg/day by gavage and 2400 mg/kg/day by diet) and bisacodyl (800-500, 4000-2000, and 8000 mg/kg/day by gavage) were administered to 15 male and 15 female and 20 male and 20 female p53(+/-) mice respectively for 26 week
Autor:
James T. MacGregor, Kerry T. Blanchard, Jun Zhang, Scott W. Burchiel, Robert L. Johnson, Bernard M. Wagner, Heath C. Thomas, Mike Lawton, Calvert Louden, Paul W. Snyder, Lester W. Schwartz, Anthony Ward, David Essayan, William Kerns, Eric Fung, Don Robertson, Frederick W. Miller, Prakash S. Nagarkatti
Publikováno v:
Toxicology and Applied Pharmacology. 203:62-87
Autor:
Supriya Jayadev, Qihong Huang, Kerry T. Blanchard, Franklin D. Pack, Elias T. Gaillard, James H. Stoltz, Brian Knight, Xidong Jin
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 549:147-167
Microarray technology continues to gain increased acceptance in the drug development process, particularly at the stage of toxicology and safety assessment. In the current study, microarrays were used to investigate gene expression changes associated
Autor:
Jeff W. Chou, Elias T. Gaillard, Raymond E. Stoll, Kerry T. Blanchard, Pierre R. Bushel, Hisham K. Hamadeh, Charles J. Tucker, Qihong Huang, Jennifer B. Collins, Robert R. Maronpot, Supriya Jayadev, Cynthia A. Afshari
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 549:169-183
Molecular techniques, such as cDNA microarrays, are being used to aid in the elucidation of the mechanisms of toxicity of a variety of compounds. In this study, we evaluate the molecular effects of furan in the rat liver. Sprague-Dawley rats were exp
Autor:
Pierre R. Bushel, Lee Bennett, Raymond E. Stoll, J. Carl Barrett, Kerry T. Blanchard, Supriya Jayadev, Cynthia A. Afshari, Olimpia DiSorbo, Stella O. Sieber, Karla Martin, Richard S. Paules, Hisham K. Hamadeh, Raymond W. Tennant
Publikováno v:
Toxicological Sciences. 67:219-231
The application of gene expression profiling technology to examine multiple genes and signaling pathways simultaneously promises a significant advance in understanding toxic mechanisms to ultimately aid in protection of public health. Public and priv
Autor:
Lee Bennett, Pierre R. Bushel, Olimpia DiSorbo, Supriya Jayadev, Raymond E. Stoll, Raymond W. Tennant, Richard S. Paules, Leping Li, Hisham K. Hamadeh, J. Carl Barrett, Kerry T. Blanchard, Cynthia A. Afshari
Publikováno v:
Toxicological Sciences. 67:232-240
DNA microarrays, used to measure the gene expression of thousands of genes simultaneously, hold promise for future application in efficient screening of therapeutic drugs. This will be aided by the development and population of a database with gene e