Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kerry Purtell"'
Autor:
Xiaoting Zhou, You-Kyung Lee, Xianting Li, Henry Kim, Carlos Sanchez-Priego, Xian Han, Haiyan Tan, Suiping Zhou, Yingxue Fu, Kerry Purtell, Qian Wang, Gay R. Holstein, Beisha Tang, Junmin Peng, Nan Yang, Zhenyu Yue
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis. Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative diseases. However, the exact role and targets of autophagy in human n
Externí odkaz:
https://doaj.org/article/71903ec458994596b1e2fc44fc246235
Autor:
Insup Choi, Yuanxi Zhang, Steven P. Seegobin, Mathilde Pruvost, Qian Wang, Kerry Purtell, Bin Zhang, Zhenyu Yue
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Microglia perform important supporting roles for neurons in the brain. Here, the authors show that microglia clear neuron-derived α-synuclein through selective autophagy (synucleinphagy) to prevent accumulation of misfolded α-synuclein and subseque
Externí odkaz:
https://doaj.org/article/666741e7ee464c8c913aa49d57227aa6
Autor:
Xiaoting Zhou, You-Kyung Lee, Xianting Li, Henry Kim, Carlos Sanchez-Priego, Xian Han, Haiyan Tan, Suiping Zhou, Yingxue Fu, Kerry Purtell, Qian Wang, Gay Holstein, Beisha Tang, Junmin Peng, Nan Yang, Zhenyu Yue
Autophagy is a catabolic and self-degradative process crucial for maintaining cellular homeostasis. Malfunctional autophagy is implicated in neurodevelopmental and neurodegenerative diseases. However, the exact role and targets of autophagy in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50839d5033cfe280f20c417a489ab614
https://doi.org/10.1101/2022.12.04.519029
https://doi.org/10.1101/2022.12.04.519029
Autor:
Wolfgang H. Oertel, A. Jon Stoessl, Samuel Burke Nanni, Laura A. Volpicelli-Daley, Kelvin C. Luk, Jose A. Obeso, Yvette C. Wong, Dimitri Krainc, Zhenyu Yue, Kerry Purtell, Louis-Eric Trudeau
Publikováno v:
Mov Disord
While current effective therapies are available for the symptomatic control of PD, treatments to halt the progressive neurodegeneration still do not exist. Loss of dopamine neurons in the SNc and dopamine terminals in the striatum drive the motor fea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe02b81e652557cb9a3881a2bb3a054f
https://doi.org/10.1002/mds.27823
https://doi.org/10.1002/mds.27823
Autor:
Insup Choi, Jia-Hong Lu, Marian Blanca Ramirez, Qin Yu, Xianting Li, Zhenyu Yue, Kerry Purtell, Zhiqiang Deng
Publikováno v:
Proc Natl Acad Sci U S A
Autophagy is a catabolic pathway that provides self-nourishment and maintenance of cellular homeostasis. Autophagy is a fundamental cell protection pathway through metabolic recycling of various intracellular cargos and supplying the breakdown produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e254914c75a02b9f6c04bc160da6114
https://doi.org/10.1073/pnas.2020215118
https://doi.org/10.1073/pnas.2020215118
Autor:
Shui-Wang Ying, Vikram A Kanda, Zhaoyang Hu, Kerry Purtell, Elizabeth C King, Geoffrey W Abbott, Peter A Goldstein
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42756 (2012)
Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate the pacemaking current, I(h), which regulates neuronal excitability, burst firing activity, rhythmogenesis, and synaptic integration. The physiological consequence of HCN ac
Externí odkaz:
https://doaj.org/article/2337e8c03c534bae8367db928133a8f7
Autor:
Torsten K Roepke, Kerry Purtell, Elizabeth C King, Krista M D La Perle, Daniel J Lerner, Geoffrey W Abbott
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11451 (2010)
Gastric cancer is the second leading cause of cancer death worldwide. Predisposing factors include achlorhydria, Helicobacter pylori infection, oxyntic atrophy and TFF2-expressing metaplasia. In parietal cells, apical potassium channels comprising th
Externí odkaz:
https://doaj.org/article/eb9ee109b51f4099a945ce6ce58a15aa
Publikováno v:
Trends in Cell Biology. 27:491-504
Previously thought of as a nonselective digestion process, autophagy is now known to specifically degrade aggregated proteins and damaged cellular organelles through the action of autophagy receptors, which provides cellular quality control and maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8eaa9701910ec04207dc8be0c9ad852
https://doi.org/10.1016/j.tcb.2017.01.001
https://doi.org/10.1016/j.tcb.2017.01.001
Publikováno v:
British Journal of Anaesthesia. 115:112-121
The mechanisms by which volatile anaesthetics such as isoflurane alter neuronal function are poorly understood, in particular their presynaptic mechanisms. Presynaptic voltage-gated sodium channels (Na(v)) have been implicated as a target for anaesth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d8ccc290f253ef5497720846cea851
https://doi.org/10.1093/bja/aev203
https://doi.org/10.1093/bja/aev203
Autor:
Elizabeth C. King, Torsten K. Roepke, Kerry Purtell, Vikram A. Kanda, Geoffrey W. Abbott, Daniel J. Lerner
Publikováno v:
Roepke, TK; Kanda, VA; Purtell, K; King, EC; Lerner, DJ; & Abbott, GW. (2011). KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB JOURNAL, 25(12), 4264-4273. doi: 10.1096/fj.11-187609. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/310856xc
Cerebrospinal fluid (CSF) is crucial for normal function and mechanical protection of the CNS. The choroid plexus epithelium (CPe) is primarily responsible for secreting CSF and regulating its composition by mechanisms currently not fully understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92936df9320855930ad2958b5f3c6c92
https://doi.org/10.1096/fj.11-187609
https://doi.org/10.1096/fj.11-187609