Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kerry P.S.J. Murphy"'
Autor:
S.W. Walters, Glenn Dallérac, Sarat C. Vatsavayai, K.A. Evans, Mark C. Hirst, C.J. Peddie, Kerry P.S.J. Murphy, Austen J. Milnerwood, Damian M. Cummings, Payam Rezaie
Publikováno v:
Neurodegenerative Diseases. 8:230-239
Background: The introduction of gene testing for Huntington’s disease (HD) has enabled the neuropsychiatric and cognitive profiling of human gene carriers prior to the onset of overt motor and cognitive symptoms. Such studies reveal an early declin
Autor:
C. Robinson, Felix Beacher, Eileen Daly, Verinder Prasher, Kerry P.S.J. Murphy, Andrew Simmons, Declan G. Murphy, Simon Lovestone, Robin G. Morris
Publikováno v:
Psychological Medicine. 39:675-684
BackgroundIndividuals with Down's syndrome (DS) are at high risk of developing Alzheimer's disease (AD). However, few studies have investigated brain anatomy in DS individuals with AD.MethodWe compared whole brain anatomy, as measured by volumetric m
Autor:
Austen J. Milnerwood, Glenn Dallérac, Kerry P.S.J. Murphy, Sarat C. Vatsavayai, Mark C. Hirst, Damian M. Cummings
Publikováno v:
Brain Research Bulletin. 72:103-107
Huntington's disease is a fatal neurodegenerative disorder characterised by a progressive motor, psychiatric and cognitive decline and associated with a marked loss of neurons in the cortex and striatum of affected individuals. The disease is inherit
Publikováno v:
Neuromolecular medicine. 18(1)
Altered dopamine receptor labelling has been demonstrated in presymptomatic and symptomatic Huntington's disease (HD) gene carriers, indicating that alterations in dopaminergic signalling are an early event in HD. We have previously described early a
Autor:
Glenn Dallérac, Damian M. Cummings, Jacki Y. Brown, Kerry P.S.J. Murphy, Payam Rezaie, Austen J. Milnerwood, Mark C. Hirst, Sarat C. Vatsavayai
Publikováno v:
Human Molecular Genetics. 15:1690-1703
Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor, psychiatric and cognitive decline. Marked neuronal loss occurs in the cortex and striatum. HD is inherited in an autosomal dominant fashion and caused
Autor:
Martín Cammarota, V. Brent, Kerry P.S.J. Murphy, K. Voss, Karl Peter Giese, K. Bradshaw, John A.P. Rostas, Timothy V. P. Bliss, Imre Lengyel
Publikováno v:
European Journal of Neuroscience. 20:3063-3072
A major role has been postulated for a maintained increase in the autonomous activity of CaMKII in the expression of long-term potentiation (LTP). However, attempts to inhibit the expression of LTP with CaMKII inhibitors have yielded inconsistent res
Publikováno v:
Neuroscience Letters. 329:217-221
The induction of long-term potentiation (LTP) at corticostriatal synapses is dependent on the activation of postsynaptic NMDA receptors, but the mechanisms involved in the maintenance of LTP are not known. We report here that forskolin, an activator
Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels
Autor:
Damian M. Cummings, Karen A. Evans, Igor Kraev, Austen J. Milnerwood, Grégoire Levasseur, Glenn Dallérac, Yoon Cho, Payam Rezaie, Sarat C. Vatsavayai, Steve W. Walters, Mark C. Hirst, Kerry P.S.J. Murphy, Chloé Huetz
Publikováno v:
Neuro-degenerative diseases. 15(2)
Background: Huntington's disease (HD) is a late-onset fatal neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the gene coding for the protein huntingtin and is characterised by progressive motor, psychiatric and cognitive d
Alterations in dopamine (DA) neurotransmission in Parkinson's disease are well known and widely studied. Much less is known about DA changes that accompany and underlie some of the symptoms of Huntington's disease (HD), a dominant inherited neurodege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1645c7c0a5cf221a9d69f0a9837f8b1
https://doi.org/10.1016/b978-0-444-63425-2.00010-6
https://doi.org/10.1016/b978-0-444-63425-2.00010-6
Autor:
Amarbirpal Mahal, Stephen B. Dunnett, Laura Mangiarini, Lisa Lione, A. Jennifer Morton, Kerry P.S.J. Murphy, Gillian P. Bates, Rebecca J. Carter
Publikováno v:
The Journal of Neuroscience. 20:5115-5123
Huntington's disease (HD) is an autosomal dominant progressive and fatal neurodegenerative brain disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the gene. Presymptomatic Huntington's disease patients often exhibit cogn