Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kerry O. Cresawn"'
Autor:
Jennifer R. Bruns, Gudrun Ihrke, Rebecca P. Hughey, Robert T. Youker, Kerry O. Cresawn, Ora A. Weisz, Polly E. Mattila, Di Mo
Publikováno v:
Traffic. 13:433-442
Many newly synthesized membrane proteins traverse endocytic intermediates en route to the surface in polarized epithelial cells; however, the biosynthetic itinerary of secreted proteins has not been elucidated. We monitored the trafficking route of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba921bd11a3d1a3e1ff7895c77fcc426
https://doi.org/10.1111/j.1600-0854.2011.01315.x
https://doi.org/10.1111/j.1600-0854.2011.01315.x
Autor:
Kerry O. Cresawn, Melissa A. Lewis, Martha Campbell-Thompson, Barry J. Byrne, Jeffry S. Kelley, Sean Germain, Denise A. Cloutier, Thomas J. Conlon, Darin J. Falk, David D. Fuller, Cathryn Mah, Thomas J. Fraites, Lara R. DeRuisseau
Publikováno v:
Molecular Therapy. 18:502-510
Pompe disease is a muscular dystrophy that results in respiratory insufficiency. We characterized the outcomes of targeted delivery of recombinant adeno-associated virus serotype 1 (rAAV2/1) vector to diaphragms of Pompe mice with varying stages of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da3eb92682c30bef5a153ecc148f70e
https://doi.org/10.1038/mt.2009.305
https://doi.org/10.1038/mt.2009.305
Publikováno v:
American Journal of Physiology-Renal Physiology. 291:F707-F713
The maintenance of apical and basolateral membrane domains with distinct protein and lipid compositions is necessary for the proper function of polarized epithelial cells. Delivery of cargo to the basolateral surface is thought to be mediated by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e100693dfd642f43142541240e7d83d0
https://doi.org/10.1152/ajprenal.00161.2006
https://doi.org/10.1152/ajprenal.00161.2006
Autor:
Melissa A. Lewis, Barry J. Byrne, Kerry O. Cresawn, I Zolotukhin, Thomas J. Fraites, Cathryn Mah, Christina A. Pacak
Publikováno v:
Gene Therapy. 12:1405-1409
Glycogen storage disease type II (GSDII) is caused by a lack of functional lysosomal acid alpha-glucosidase (GAA). Affected individuals store glycogen in lysosomes beginning during gestation, ultimately resulting in fatal hypertrophic cardiomyopathy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c75762ff4d321a1460b86af5f6e1f6
https://doi.org/10.1038/sj.gt.3302550
https://doi.org/10.1038/sj.gt.3302550
Autor:
Melissa A. Lewis, Cathryn Mah, Barry J. Byrne, Irene Zolotukhin, Thomas J. Fraites, Kerry O. Cresawn
Publikováno v:
Molecular Therapy. 9:458-463
Genetically modified mice are important models for evaluation of potential gene therapies for human diseases. However, their small size often precludes the use of clinically feasible methods for vector delivery, therefore, alternative methods must be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e4ab18493db41c8849ff56f5541d19
https://doi.org/10.1016/j.ymthe.2004.01.006
https://doi.org/10.1016/j.ymthe.2004.01.006
Publikováno v:
Concepts in Genetic Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d200d8f35bd3c04abcf5e3a08a2735f
https://doi.org/10.1002/9780470184585.ch10
https://doi.org/10.1002/9780470184585.ch10
Autor:
Beth A. Potter, Gudrun Ihrke, Ora A. Weisz, Gerard Apodaca, Kerry O. Cresawn, Asli Oztan, James R. Goldenring, Christopher J. Guerriero
Publikováno v:
The EMBO journal. 26(16)
Newly synthesized basolateral markers can traverse recycling endosomes en route to the surface of Madin–Darby canine kidney cells; however, the routes used by apical proteins are less clear. Here, we functionally inactivated subsets of endocytic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7657bf1eb277308133f2d8a014d6ea
https://pubmed.ncbi.nlm.nih.gov/17673908
https://pubmed.ncbi.nlm.nih.gov/17673908
Autor:
Kerry O. Cresawn, Cathryn Mah, Melissa A. Lewis, Christina A. Pacak, Barry J. Byrne, Sean Germain
Publikováno v:
Molecular Therapy. 13
Top of pageAbstract The long term goal of this project is to develop a clinically relevant gene therapy approach for the treatment of Pompe Disease. Pompe Disease is a form of muscular dystrophy and metabolic myopathy caused by mutations in the acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a824f265db546ed738df740123328811
Autor:
Barry J. Byrne, Kerry O. Cresawn
Publisher Summary This chapter discusses gene therapy for the treatment of lysosomal storage diseases (LRDs). Gene therapy is an attractive alternative to enzyme replacement therapy (ERT) for several reasons. Gene therapy offers the potential for a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ff9631ef90f0cd39880f96d72ece5e
https://doi.org/10.1016/s0075-7535(05)31010-2
https://doi.org/10.1016/s0075-7535(05)31010-2
Autor:
Melissa A. Lewis, Thomas J. Fraites, Cathryn Mah, Irene Zolotukhin, Kerry O. Cresawn, Barry J. Byrne
Publikováno v:
Molecular Therapy. 11:S351-S352
Top of pageAbstract Glycogen storage disease type II (GSDII), is a lysosomal storage disease caused by a partial to complete deficiency in the lysosomal hydrolase, acid |[alpha]|-glucosidase (GAA). From gestation, affected individuals store glycogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f2671493bae378b5c41fb3bf1af1472
https://doi.org/10.1016/j.ymthe.2005.07.452
https://doi.org/10.1016/j.ymthe.2005.07.452