Výsledky vyhledávání - "Kerry L. Sanders"

Gene Expression Analysis Reveals Distinct Pathways of Resistance to Bevacizumab in Xenograft Models of Human ER-Positive Breast Cancer

Autor: Chirayu P. Goswami, Mircea Ivan, George W. Sledge, Rachel A. Toroni, Bogdan Tanasa, Usha Sirimalle, Kerry L. Sanders, Yesim Gökmen-Polar, Changyu Shen, Sunil Badve, Rutika Mehta, Lang Li

Publikováno v: Journal of Cancer

Bevacizumab, the recombinant antibody targeting vascular endothelial growth factor (VEGF), improves progression-free but not overall survival in metastatic breast cancer. To seek further insights in resistance mechanisms to bevacizumab at the molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b604a6f49b5ce592a16e427a03a11dd3
https://doi.org/10.7150/jca.8466

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Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes

Autor: Mangesh A. Thorat, George W. Sledge, Spyro Mousses, David G. Huntsman, Rutika Mehta, Samuel Leung, Yesim Gökmen-Polar, Sukru Tuzmen, Dmitry Turbin, Kerry L. Sanders, Sunil Badve

Publikováno v: Breast Cancer Research and Treatment. 124:327-335

Protein kinase C betaII (PKCβII) represents a novel potential target for anticancer therapies in breast cancer. In order to identify patient subgroups which might benefit from PKC-targeting therapies, we investigated the expression of PKCβII in hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431032b63aa5aae81523b71e2a2610f9
https://doi.org/10.1007/s10549-010-0733-2

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Mycobacteria Induces Pleural Mesothelial Permeability by Down-Regulating β-Catenin Expression

Autor: Veena B. Antony, R D Van Horn, Joyce Hardwick, Kamal A. Mohammed, Kerry L. Sanders, Najmunnisa Nasreen

Publikováno v: Lung. 181:57-66

Patients with pulmonary tuberculosis develop pleural effusions with a high protein content. Pleural mesothelial adherens junctions promote mesothelial cell-cell adhesion and contribute to pleural integrity. In the present study we have investigated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274cf7205d0fab5bd5aa4b96181ebabc
https://doi.org/10.1007/s00408-003-1006-1

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Pleural Mesothelial Cell (PMC) Defense Mechanisms Against Malignancy

Autor: Joyce Hardwick, Chadi A. Hage, Kamal A. Mohammed, Kerry L. Sanders, Robert D. Van Horn, Carlos Ramirez-Icaza, Najmunnisa Nasreen, Veena B. Antony, P. S. Sriram

Publikováno v: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 14:155-161

Tumors such as ovarian, lung, and breast have been found to have a predilection for the pleura. Pleural mesothelial cells (PMCs) play an active role in pleural inflammation via release of cytokines. However, mechanisms whereby PMCs defend themselves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb2be15c72bb51e8641efe617b279c4
https://doi.org/10.3727/000000003771013053

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[Untitled]

Autor: Muna M. Kilani, Kerry L. Sanders, Robert D. Van Horn, Najmunnisa Nasreen, Kamal A. Mohammed, Ramit K. Sharma, Joyce Hardwick, Veena B. Antony

Publikováno v: Journal of Clinical Immunology. 23:1-10

In bacterial empyema, the recruited polymorphonuclear leukocytes (PMN) represent important phagocytic cells involved in antibacterial defense. In this study we demonstrate that pleural fluids (PF) obtained from patients with empyema (EMP) contains si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d27ec58494c0c65a22e2ea2ed52a7be6
https://doi.org/10.1023/a:1021958529763

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[Untitled]

Autor: Najmunnisa Nasreen, Veena B. Antony, Robert D. Van Horn, Joyce Hardwick, Kerry L. Sanders, Farzad Loghmani, Kamal A. Mohammed

Publikováno v: Inflammation. 26:73-82

Current knowledge implicates pleural mesothelial cells as mainly responsible for inflammatory responses in the pleural space. However, a vast body of recent evidence underscores the important role of fibroblasts in the process of inflammation in seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5392906e8a1192c78f2220d8e3fdfad
https://doi.org/10.1023/a:1014884127573

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Polar Production of Interleukin‐8 by Mesothelial Cells Promotes the Transmesothelial Migration of Neutrophils: Role of Intercellular Adhesion Molecule–1

Autor: Kerry L. Sanders, Jeff W. Hott, Robert D. Van Horn, Najmunnisa Nasreen, Joyce Hardwick, Veena B. Antony, C. M. Doerschuk, Kamal A. Mohammed

Publikováno v: The Journal of Infectious Diseases. 183:1638-1645

Migration of polymorphonuclear neutrophils (PMNL) from the vascular compartment into the pleural space occurs rapidly during the development of parapneumonic effusions. This study investigated the polarized secretion of interleukin (IL)-8 in activate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf853cedbf2a2933198aec56fca379f
https://doi.org/10.1086/320700

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Establishment and characterization of a novel cell line derived from human thymoma AB tumor

Autor: Gail H. Vance, Danielle Smith, Robert P. Nelson, Angelo A. Cardoso, Rohit Jain, Chirayu P. Goswami, Lang Li, Kenneth A. Kesler, Yesim Gökmen-Polar, Narjis A. Zaheer, Sunil Badve, Patrick J. Loehrer, Kerry L. Sanders, George W. Sledge, Oscar D Cano

Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 92(11)

Thymomas are low-grade epithelial tumors of the anterior mediastinum. The complexity of the disease and the lack of in vitro and in vivo models hamper the development of better therapeutics. In this study, we report a novel cell line, designated as I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87bc84f9013a3af50e9a3710ddaeea04
https://pubmed.ncbi.nlm.nih.gov/22926645

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Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models

Autor: Yesim Gökmen-Polar, Rachel A. Toroni, George W. Sledge, Christian Rommel, Rutika Mehta, Sunil Badve, Kerry L. Sanders, Yi Liu

Publikováno v: Breast cancer research and treatment. 136(3)

Aberrant activation of the mammalian target of rapamycin (mTOR) signaling plays an important role in breast cancer progression and represents a potential therapeutic target for breast cancer. In this study, we report the impact of the investigational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c15bf53cc75d356abb888cdf1667dd5
https://pubmed.ncbi.nlm.nih.gov/23085766

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