Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Kerry L, Price"'
Autor:
Marijke Brams, Cedric Govaerts, Kumiko Kambara, Kerry L Price, Radovan Spurny, Anant Gharpure, Els Pardon, Genevieve L Evans, Daniel Bertrand, Sarah CR Lummis, Ryan E Hibbs, Jan Steyaert, Chris Ulens
Publikováno v:
eLife, Vol 9 (2020)
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but modify coupling of liga
Externí odkaz:
https://doaj.org/article/342cb67467c141c1a4b0ebacf9821115
Publikováno v:
ACS chemical neuroscience. 11(10)
Nicotinic acetylcholine receptors (nAChR) are the archetypal members of the pentameric ligand-gated ion channel (pLGIC) family, an important class of cell signaling proteins. In all members of this family, each of the five subunits has four transmemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae15889920e78f9b479923f6734b9ad
https://pubmed.ncbi.nlm.nih.gov/32364364
https://pubmed.ncbi.nlm.nih.gov/32364364
Autor:
Chris Ulens, Els Pardon, Genevieve L. Evans, D. Bertrand, Kumiko Kambara, Jan Steyaert, Radovan Spurny, Cédric Govaerts, Marijke Brams, Kerry L. Price, Sarah C. R. Lummis, Ryan E. Hibbs, Anant Gharpure
Publikováno v:
eLife, 9
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but modify coupling of liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f200d44ca2bed9d9f15b016115158c76
https://hdl.handle.net/20.500.14017/ebfd9a6c-7f5a-4ce5-b0f7-d5a8a10d56d2
https://hdl.handle.net/20.500.14017/ebfd9a6c-7f5a-4ce5-b0f7-d5a8a10d56d2
Autor:
Cédric Govaerts, Radovan Spurny, Els Pardon, Sarah C. R. Lummis, Ryan E. Hibbs, Marijke Brams, Daniel Bertrand, Chris Ulens, Kerry L. Price, Kumiko Kambara, Jan Steyaert, Anant Gharpure, Genevieve L. Evans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d0c6450ee6f3fb72e132979c0087082
https://doi.org/10.7554/elife.51511.sa2
https://doi.org/10.7554/elife.51511.sa2
Autor:
Sarah C. R. Lummis, Kerry L. Price
Publikováno v:
ACS Chemical Neuroscience. 9:1409-1415
Cys-loop receptors are major sites of action for many important therapeutically active compounds, but the sites of action of those that do not act at the orthosteric binding site or at the pore are mostly poorly understood. To help understand these,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6ba58d213fd082ff621791728c494ed
https://doi.org/10.1021/acschemneuro.8b00028
https://doi.org/10.1021/acschemneuro.8b00028
Publikováno v:
ACS Chemical Neuroscience. 8:1085-1091
5-HT3 receptors are members of the Cys-loop family of ligand-gated ion channels, and, like most members of this family, there are multiple subunits that can contribute to functional pentameric receptors. 5-HT3A and 5-HT3AB receptors have been extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dda43c25ca7fa31d35e700136c64102
https://doi.org/10.1021/acschemneuro.6b00416
https://doi.org/10.1021/acschemneuro.6b00416
Autor:
Anant Gharpure, Els Pardon, Genevieve L. Evans, Marijke Brams, Radovan Spurny, Jan Steyaert, Sarah C. R. Lummis, Daniel Bertrand, Cédric Govaerts, Ryan E. Hibbs, Chris Ulens, Kumiko Kambara, Kerry L. Price
Pentameric ligand-gated ion channels (pLGICs) belong to a class of ion channels involved in fast synaptic signaling in the central and peripheral nervous systems. Molecules acting as allosteric modulators target binding sites that are remote from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20a0856acba74cd3d20e5473cefba55
https://doi.org/10.1101/770719
https://doi.org/10.1101/770719
Autor:
Marijke, Brams, Cedric, Govaerts, Kumiko, Kambara, Kerry L, Price, Radovan, Spurny, Anant, Gharpure, Els, Pardon, Genevieve L, Evans, Daniel, Bertrand, Sarah Cr, Lummis, Ryan E, Hibbs, Jan, Steyaert, Chris, Ulens
Publikováno v:
eLife
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but modify coupling of liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c3ed64939ed2946da544d5f4b660af5
https://pubmed.ncbi.nlm.nih.gov/31990273
https://pubmed.ncbi.nlm.nih.gov/31990273
Autor:
Kerry L, Price, Sarah C R, Lummis
Publikováno v:
ACS chemical neuroscience. 9(6)
Cys-loop receptors are major sites of action for many important therapeutically active compounds, but the sites of action of those that do not act at the orthosteric binding site or at the pore are mostly poorly understood. To help understand these,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b8da4d9ae021e21a706a7f924f2e654
https://pubmed.ncbi.nlm.nih.gov/29508995
https://pubmed.ncbi.nlm.nih.gov/29508995
Publikováno v:
Biochemistry. 56(15)
Prokaryotic homologues of Cys-loop receptors have proven to be useful in understanding their eukaryotic counterparts, but even the best studied of these, Gloeobacter ligand-gated ion channel (GLIC), is still not yet fully understood. GLIC is activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ccc9d9447fff0ec54862c2b4c2cbb25f
https://pubmed.ncbi.nlm.nih.gov/28383883
https://pubmed.ncbi.nlm.nih.gov/28383883