Výsledky vyhledávání - "Kerry J. Goodworth"

Synthesis and in vivo biological activity of large-ringed calixarenes against Mycobacterium tuberculosis

Autor: Isabel Casades, M. Joseph Colston, Helen C. Hailes, Kerry J. Goodworth, Alison M. Hill, Ricardo E. Tascon, Gordon G. Weingarten, Gwenaelle Hervé, Anne-Cécile Hervé, Evangelos Stavropoulos

Publikováno v: Tetrahedron. 67:373-382

A series of large-ringed calix[6,7,8]arene analogues have been synthesised and their affect against Mycobacterium tuberculosis in vivo established. In general, when p-phenylcalixarenes and tert-butylcalixarenes were not functionalised at the lower ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c88d73917a5e7939ccadd81397e18f90
https://doi.org/10.1016/j.tet.2010.11.034

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Antimycobacterial Calixarenes Enhance Innate Defense Mechanisms in Murine Macrophages and Induce Control ofMycobacterium tuberculosisInfection in Mice

Autor: Evangelos Stavropoulos, Gwenaelle Hervé, Philip D. Hart, Peter J. Jenner, Kerry J. Goodworth, Ricardo E. Tascon, M. Joseph Colston, Helen C. Hailes, Alison M. Hill, Anne C. Herve

Publikováno v: Infection and Immunity. 72:6318-6323

Mycobacterium tuberculosis infects one-third of the world's population, and it accounts for more deaths each year than any other infectious bacterium (13). The problem, associated with multiple-drug resistance (12), has prompted a great interest in u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3febf90bd364d578ac2cdfe49c105d9
https://doi.org/10.1128/iai.72.11.6318-6323.2004

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The selective functionalisation and difunctionalisation of p-substituted calix[6]arene and calix[8]arenes using hydrophilic moieties

Autor: Gwenaelle Hervé, Helen C. Hailes, Anne-Cécile Hervé, Dirk Uwe Hahn, Kerry J. Goodworth, Alison M. Hill

Publikováno v: Organicbiomolecular chemistry. 1(2)

Methodologies to access water soluble large ringed calixarenes in good yield using efficient synthetic procedures have been investigated. Symmetrical partial functionalisations at the lower rim are described using activated [n]ethylene glycol chains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11130187c69999a0f5f60ca7c42a3b93
https://pubmed.ncbi.nlm.nih.gov/12929441

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