Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Kerry Fenwick"'
Autor:
Katharina von Loga, Andrew Woolston, Marco Punta, Louise J. Barber, Beatrice Griffiths, Maria Semiannikova, Georgia Spain, Benjamin Challoner, Kerry Fenwick, Ronald Simon, Andreas Marx, Guido Sauter, Stefano Lise, Nik Matthews, Marco Gerlinger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Tumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.
Externí odkaz:
https://doaj.org/article/f202e0a95a5045ca81301d8ebb687ecf
Autor:
Jen Y. Lee, Rosalind J. Cutts, Ingrid White, Yolanda Augustin, Isaac Garcia-Murillas, Kerry Fenwick, Nik Matthews, Nicholas C. Turner, Kevin Harrington, Duncan C. Gilbert, Shreerang Bhide
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Background: Following chemo-radiotherapy (CRT) for human papilloma virus positive (HPV+) anal squamous cell carcinoma (ASCC), detection of residual/recurrent disease is challenging. Patients frequently undergo unnecessary repeated biopsies for abnorm
Externí odkaz:
https://doaj.org/article/237f71c14eef4ff8bb19bc7f8c8b1eea
Autor:
Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I. Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N. Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M. Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells, su
Externí odkaz:
https://doaj.org/article/1eb977c74fb546b0a7321e49be5d0643
Autor:
Joseph S. Baxter, Olivia C. Leavy, Nicola H. Dryden, Sarah Maguire, Nichola Johnson, Vita Fedele, Nikiana Simigdala, Lesley-Ann Martin, Simon Andrews, Steven W. Wingett, Ioannis Assiotis, Kerry Fenwick, Ritika Chauhan, Alistair G. Rust, Nick Orr, Frank Dudbridge, Syed Haider, Olivia Fletcher
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Risk loci for breast cancer have been identified by genome-wide association studies. Here, the authors use Capture Hi-C to identify 110 putative target genes at 33 loci and assessed associations of gene expression, SNP genotype, and survival, providi
Externí odkaz:
https://doaj.org/article/04f38edcab7d46faa2e61354e4ef0a11
Autor:
Saira Khalique, Sarah Nash, David Mansfield, Julian Wampfler, Ayoma Attygale, Katherine Vroobel, Harriet Kemp, Richard Buus, Hannah Cottom, Ioannis Roxanis, Thomas Jones, Katharina von Loga, Dipa Begum, Naomi Guppy, Pradeep Ramagiri, Kerry Fenwick, Nik Matthews, Michael J. F. Hubank, Christopher J. Lord, Syed Haider, Alan Melcher, Susana Banerjee, Rachael Natrajan
Publikováno v:
Cancers, Vol 13, Iss 15, p 3854 (2021)
Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer characterised by a high frequency of loss-of-function ARID1A mutations and a poor response to chemotherapy. Despite their generally low mutational burden, an intratumo
Externí odkaz:
https://doaj.org/article/4572fce1c8e0454eb8e4726155bb806e
Autor:
Irene Y. Chong, Naureen Starling, Alistair Rust, John Alexander, Lauren Aronson, Marta Llorca-Cardenosa, Ritika Chauhan, Asif Chaudry, Sacheen Kumar, Kerry Fenwick, Ioannis Assiotis, Nik Matthews, Ruwaida Begum, Andrew Wotherspoon, Monica Terlizzo, David Watkins, Ian Chau, Christopher J. Lord, Syed Haider, Sheela Rao, David Cunningham
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 2, p 215 (2021)
1. Background: The application of massively parallel sequencing has led to the identification of aberrant druggable pathways and somatic mutations within therapeutically relevant genes in gastro-oesophageal cancer. Given the widespread use of formali
Externí odkaz:
https://doaj.org/article/915bb413902f4856b83979729b3dfa2c
Autor:
Franciele H. Knebel, Louise J. Barber, Alice Newey, Dimitrios Kleftogiannis, Andrew Woolston, Beatrice Griffiths, Kerry Fenwick, Fabiana Bettoni, Maurício Fernando Silva Almeida Ribeiro, Leonardo da Fonseca, Frederico Costa, Fernanda Cunha Capareli, Paulo M. Hoff, Jorge Sabbaga, Anamaria A. Camargo, Marco Gerlinger
Publikováno v:
Cancers, Vol 12, Iss 12, p 3736 (2020)
Epidermal growth factor receptor antibodies (EGFR-Abs) confer a survival benefit in patients with RAS wild-type metastatic colorectal cancer (mCRC), but resistance invariably occurs. Previous data showed that only a minority of cancer cells harboured
Externí odkaz:
https://doaj.org/article/e970d1f815a34c0a9c494aaa8a281edc
Autor:
Katharina von Loga, Andrew Woolston, Marco Punta, Louise J. Barber, Beatrice Griffiths, Maria Semiannikova, Georgia Spain, Benjamin Challoner, Kerry Fenwick, Ronald Simon, Andreas Marx, Guido Sauter, Stefano Lise, Nik Matthews, Marco Gerlinger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ce49983b14724f1b9d01517d1acc50e3
Autor:
Alexandra Pender, Isaac Garcia-Murillas, Sareena Rana, Rosalind J Cutts, Gavin Kelly, Kerry Fenwick, Iwanka Kozarewa, David Gonzalez de Castro, Jaishree Bhosle, Mary O'Brien, Nicholas C Turner, Sanjay Popat, Julian Downward
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139074 (2015)
Droplet digital PCR (ddPCR) can be used to detect low frequency mutations in oncogene-driven lung cancer. The range of KRAS point mutations observed in NSCLC necessitates a multiplex approach to efficient mutation detection in circulating DNA. Here w
Externí odkaz:
https://doaj.org/article/88c33bf7384544fe97dd5e434f1ac05f
Autor:
Stephen J Pettitt, Farah L Rehman, Ilirjana Bajrami, Rachel Brough, Fredrik Wallberg, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, Lina Chen, James Campbell, Christopher J Lord, Alan Ashworth
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61520 (2013)
Genetic perturbation screens have the potential to dissect a wide range of cellular phenotypes. Such screens have historically been difficult in diploid mammalian cells. The recent derivation of haploid embryonic stem cells provides an opportunity to
Externí odkaz:
https://doaj.org/article/e0b684f60ba24e7a892ea6f6dcb1a2c1