Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Kerry D. Fisher"'
Autor:
Eleanor M. Scott, Egon J. Jacobus, Brian Lyons, Sally Frost, Joshua D. Freedman, Arthur Dyer, Hena Khalique, William K. Taverner, Alison Carr, Brian R. Champion, Kerry D. Fisher, Len W. Seymour, Margaret R. Duffy
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Background Tumour-associated macrophages (TAMs) are often implicated in cancer progression but can also exert anti-tumour activities. Selective eradication of cancer-promoting (M2-like) TAM subsets is a highly sought-after goal. Here, we hav
Externí odkaz:
https://doaj.org/article/d5fee97270fd469da9e2aa78cc47e661
Autor:
Janet Lei, Egon J. Jacobus, William K. Taverner, Kerry D. Fisher, Silvio Hemmi, Katy West, Lorna Slater, Fred Lilley, Alice Brown, Brian Champion, Margaret R. Duffy, Len W. Seymour
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-16 (2018)
Abstract Background Oncolytic viruses are currently experiencing accelerated development in several laboratories worldwide, with some forty-seven clinical trials currently recruiting. Many oncolytic viruses combine targeted cytotoxicity to cancer cel
Externí odkaz:
https://doaj.org/article/44a96f0e06e746ad9b16a6d3e39bf2b3
Autor:
Joshua D Freedman, Joachim Hagel, Eleanor M Scott, Ioannis Psallidas, Avinash Gupta, Laura Spiers, Paul Miller, Nikolaos Kanellakis, Rebecca Ashfield, Kerry D Fisher, Margaret R Duffy, Leonard W Seymour
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1067-1087 (2017)
Abstract Oncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group B adenovirus EnAdenotucirev (EnAd) to express a bi
Externí odkaz:
https://doaj.org/article/65cb8311f33a4664948ad2d02957a40c
Autor:
Arthur Dyer, Ying Di, Hugo Calderon, Sam Illingworth, Gray Kueberuwa, Alison Tedcastle, Phil Jakeman, Suet Lin Chia, Alice Brown, Michael A. Silva, David Barlow, John Beadle, Terry Hermiston, David J.P. Ferguson, Brian Champion, Kerry D. Fisher, Leonard W. Seymour
Publikováno v:
Molecular Therapy: Oncolytics, Vol 4, Iss C, Pp 18-30 (2017)
Enadenotucirev (EnAd) is a chimeric group B adenovirus isolated by bioselection from a library of adenovirus serotypes. It replicates selectively in and kills a diverse range of carcinoma cells, shows effective anticancer activity in preclinical syst
Externí odkaz:
https://doaj.org/article/002ab69ebda84c369b82dc56d1ee6d03
Autor:
Kerry D. Fisher, Leonard W. Seymour, Brian R. Champion, Paul Miller, Adam Lambert, Clare Verrill, Richard J. Bryant, Leticia Campo, Joachim Hagel, Eleanor M. Scott, Alice Muntzer, Janet Lei-Rossmann, Margaret R. Duffy, Joshua D. Freedman
Supplementary Files detailing additional experiments supporting the conclusions of the manuscript, including additional activation, cytotoxicity, and cytokine analyses. Supplementary tables contain more details on characterisation of patient biopsies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485e705c7efbfb716257f1d09ff10e04
https://doi.org/10.1158/0008-5472.22419483
https://doi.org/10.1158/0008-5472.22419483
Autor:
Kerry D. Fisher, Leonard W. Seymour, Brian R. Champion, Paul Miller, Adam Lambert, Clare Verrill, Richard J. Bryant, Leticia Campo, Joachim Hagel, Eleanor M. Scott, Alice Muntzer, Janet Lei-Rossmann, Margaret R. Duffy, Joshua D. Freedman
Time-lapse sequence of uninfected control cultures of DLD, NHDF, and T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2faf0839ee83d77b36795cc68ec037f
https://doi.org/10.1158/0008-5472.22419492.v1
https://doi.org/10.1158/0008-5472.22419492.v1
Autor:
Kerry D. Fisher, Leonard W. Seymour, Brian R. Champion, Paul Miller, Adam Lambert, Clare Verrill, Richard J. Bryant, Leticia Campo, Joachim Hagel, Eleanor M. Scott, Alice Muntzer, Janet Lei-Rossmann, Margaret R. Duffy, Joshua D. Freedman
Effective immunotherapy of stromal-rich tumors requires simultaneous targeting of cancer cells and immunosuppressive elements of the microenvironment. Here, we modified the oncolytic group B adenovirus enadenotucirev to express a stroma-targeted bisp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c1027b95bdb83ff43117766fe19c258
https://doi.org/10.1158/0008-5472.c.6510393.v1
https://doi.org/10.1158/0008-5472.c.6510393.v1
Autor:
Victor Ramos, Kerry D. Fisher, Claudia Hill, Robert Carlisle, Constantin C. Coussios, Len Seymour, Luca Bau, Joel Balkaran, Megan Grundy, Sheena Wallington
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 47-61 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Vaccinia virus (VV) is a powerful tool for cancer treatment with the potential for tumor tropism, efficient cell-to-cell spread, rapid replication in cancer cells, and stimulation of anti-tumor immunity. It has a well-defined safety profile and is be
Autor:
Sean M. O’Cathail, Tzveta D. Pokrovska, Timothy S. Maughan, Kerry D. Fisher, Leonard W. Seymour, Maria A. Hawkins
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Oncolytic viruses and radiotherapy represent two diverse areas of cancer therapy, utilizing quite different treatment modalities and with non-overlapping cytotoxicity profiles. It is, therefore, an intriguing possibility to consider that oncolytic (
Externí odkaz:
https://doaj.org/article/54f24e7536744acd8e74ee8f8364e959
Autor:
Nalini Marino, Sam Illingworth, Prithvi Kodialbail, Ashvin Patel, Hugo Calderon, Rochelle Lear, Kerry D Fisher, Brian R Champion, Alice C N Brown
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177810 (2017)
Oncolytic viruses which infect and kill tumour cells can also be genetically modified to express therapeutic genes that augment their anti-cancer activities. Modifying oncolytic viruses to produce effective cancer therapies is challenging as encoding
Externí odkaz:
https://doaj.org/article/91f88a97391341e4b1e62c1a9d9294db