Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kerry Chapman"'
Autor:
Stephen Schmidt, Kevin R Clark, Joseph P. Lyssikatos, Brent A. Appleton, Joy Drobnick, Huifen Chen, Christian Wiesmann, Kerry Chapman, Jason Halladay, Ivana Yen, Ping Wu, Lewis J. Gazzard, Simon Charles Goodacre, Steve Sideris, Shiva Malek, Karen Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5704-5709
Checkpoint kinase 1 (ChK1) is activated in response to DNA damage, acting to temporarily block cell cycle progression and allow for DNA repair. It is envisaged that inhibition of ChK1 will sensitize tumor cells to treatment with DNA-damaging therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ab92dabfac7006eb7c98b64e04605b
https://doi.org/10.1016/j.bmcl.2014.10.063
https://doi.org/10.1016/j.bmcl.2014.10.063
Autor:
Yuzhong Deng, Susan Summerhill, Benjamin Fauber, Maxine Norman, Alberto Gobbi, Adrian Barnard, Kerry Chapman, Adam R. Johnson, Olivier Rene, Harvey Wong, Christine Everett, Hank La, Gary Salmon, Celine Eidenschenk
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(18)
Modification of the δ-sultam ring of RORc inverse agonist 2 led to the discovery of more polar oxa-sultam 65. The less lipophilic inverse agonist (65) displayed high potency in a biochemical assay, which translated into inhibition of IL-17 productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fca3900a945d8ef4376c70bfb26aaf7
https://pubmed.ncbi.nlm.nih.gov/27524313
https://pubmed.ncbi.nlm.nih.gov/27524313
Autor:
Stewart Who, Mark Oakley, Michelle Nicolaou, Graham Alldus, John Ramsey, Paul I. Dargan, David M. Wood, Denise Huggett, Karen Sturgeon, Eren Bessim, Kelvin Julian, Kerry Chapman
Publikováno v:
Journal of Substance Use. 15:237-245
Background: Recreational drug use in common, particularly in those attending nightclubs. Their knowledge about the potential toxicity of drugs and how to manage this is variable.Methods: We therefore established a multidisciplinary local network of k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c5debb7bae497a234e2751b50e2bd09
https://doi.org/10.3109/14659890903141090
https://doi.org/10.3109/14659890903141090
Autor:
Guillaume Médard, Stephen P. Schmidt, Raman Narukulla, Emanuela Gancia, Jason Halladay, Sarah Major, Sharon Yee, Brenda Burton, Ping Wu, Lorraine Axford, Simon Charles Goodacre, Michael Flagella, Eileen Mary Seward, Joy Drobnick, Joanne Hewitt, Charles Ellwood, Lewis J. Gazzard, Judi Ramiscal, Samuel Kintz, Matthew Gill, Calum Macleod, Hazel Hunt, Kerry Chapman, Shiva Malek, Peter H. Crackett, Huifen Chen, Christian Wiesmann, Ivana Yen, Jennifer Epler, Karen Williams, Elizabeth Blackwood, Joseph P. Lyssikatos
Publikováno v:
Journal of medicinal chemistry. 58(12)
Checkpoint kinase 1 (ChK1) plays a key role in the DNA damage response, facilitating cell-cycle arrest to provide sufficient time for lesion repair. This leads to the hypothesis that inhibition of ChK1 might enhance the effectiveness of DNA-damaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfa27960fc92cee387acb5db5e8b8fb
https://pubmed.ncbi.nlm.nih.gov/25988399
https://pubmed.ncbi.nlm.nih.gov/25988399
Autor:
Fionna Moore, S L Greene, David M. Wood, Denise Huggett, Michelle Nicolaou, Graham Alldus, Kerry Chapman, Nicola Drake, Kim Heather, Paul I. Dargan
Publikováno v:
Substance Abuse Treatment, Prevention, and Policy, Vol 3, Iss 1, p 14 (2008)
Substance Abuse Treatment, Prevention, and Policy
Substance Abuse Treatment, Prevention, and Policy
Background Previously developed 'club guidelines' developed for club owners and promoters have tended to focus more on the legislative aspects of clubs, rather than the medical management of unwell clubbers within club environments. Despite this lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bbfcfb1df07b420ace5a67d31576df
http://www.substanceabusepolicy.com/content/3/1/14
http://www.substanceabusepolicy.com/content/3/1/14