Výsledky vyhledávání - "Kerry Breheney"

Akademický článek

Ammonium hydroxide treatment of Aβ produces an aggregate free solution suitable for biophysical and cell culture characterization

Autor: Timothy M. Ryan, Joanne Caine, Haydyn D.T. Mertens, Nigel Kirby, Julie Nigro, Kerry Breheney, Lynne J. Waddington, Victor A. Streltsov, Cyril Curtain, Colin L. Masters, Blaine R. Roberts

Publikováno v: PeerJ, Vol 1, p e73 (2013)

Alzheimer’s disease is the leading cause of dementia in the elderly. Pathologically it is characterized by the presence of amyloid plaques and neuronal loss within the brain tissue of affected individuals. It is now widely hypothesised that fibrill

Externí odkaz: https://doaj.org/article/7b1183117385402f99febb60c89c705d

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Engineered Bacterially Expressed Polypeptides: Assembly into Polymer Particles with Tailored Degradation Profiles

Autor: Denison H. C. Chang, Kim L. Wark, Angus P. R. Johnston, Frank Caruso, Kerry Breheney

Publikováno v: Angewandte Chemie. 124:475-479

In nature, the sequence of amino acids in a protein is determined by the genetic code. Biosynthesis of polypeptides by bacteria can be used to exploit this natural process to afford exact control over properties such as molecular weight, chemical fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c601c9fc009beb04fdcdf1c4d7bd55b
https://doi.org/10.1002/ange.201106033

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Design of non-aggregating variants of Aβ peptide

Autor: Victor A. Streltsov, Julie Nigro, Stewart D. Nuttall, Lynne J. Waddington, Colin L. Masters, Joanne M. Caine, Kerry Breheney, Quentin I. Churches

Publikováno v: Biochemical and biophysical research communications. 453(3)

Self association of the amyloid-β (Aβ42) peptide into oligomers, high molecular weight forms, fibrils and ultimately neuritic plaques, has been correlated with progressive cognitive decline in Alzheimer’s disease. Thus, insights into the drivers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9cc0fd819950d6876853cc6eb246d2
https://pubmed.ncbi.nlm.nih.gov/25281534

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Central amyloid-β-specific single chain variable fragment ameliorates Aβ aggregation and neurotoxicity

Autor: Stewart D. Nuttall, Meghan Hattarki, Kerry Breheney, Julie Nigro, Rebecca M. Nisbet, Joanne M. Caine

Publikováno v: Protein engineering, designselection : PEDS. 26(10)

Anti-amyloid-β immunotherapies are a promising therapeutic approach for the treatment and prevention of Alzheimer's disease (AD). Single chain antibody fragments (scFv) are an attractive alternative to whole antibodies due to their small size, singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f01d70e2ae2c351bfee913cf813afb
https://pubmed.ncbi.nlm.nih.gov/23766374

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Ammonium hydroxide treatment of Aβ produces an aggregate free solution suitable for biophysical and cell culture characterization

Autor: Blaine R. Roberts, Nigel Kirby, Colin L. Masters, Kerry Breheney, Haydyn D. T. Mertens, Timothy M. Ryan, Victor A. Streltsov, Julie Nigro, Lynne J. Waddington, Cyril C. Curtain, Joanne M. Caine

Publikováno v: PeerJ, Vol 1, p e73 (2013)
PeerJ

Alzheimer's disease is the leading cause of dementia in the elderly. Pathologically it is characterized by the presence of amyloid plaques and neuronal loss within the brain tissue of affected individuals. It is now widely hypothesised that fibrillar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc26584fea6cade2c4bccff83f1770c
https://peerj.com/articles/73/

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Biodistribution of polymer hydrogel capsules for the delivery of therapeutics

Autor: Kerry Breheney, Kim L. Wark, Mark Tizard, Joseph A. Nicolazzo, Tracey M. Hinton, Sander A.A. Kooijmans, Diane Green, Shuning Shi, Alexander N. Zelikin, Paul Monaghan

Publikováno v: Hinton, T M, Monaghan, P, Green, D, Kooijmans, S A A, Shi, S, Breheney, K, Tizard, M, Nicolazzo, J A, Zelikin, A N & Wark, K 2012, ' Biodistribution of polymer hydrogel capsules for the delivery of therapeutics ', Acta Biomaterialia, vol. 8, no. 9, pp. 3251-60 . https://doi.org/10.1016/j.actbio.2012.05.028

A key phase in the development of intelligently designed nanoparticle delivery vehicles for new therapeutic agents is to gain an understanding of their interaction with tissues and cells. We report a series of in vitro and in vivo experiments aimed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc40c02f91c9b229fae5f0e717004e57
https://pubmed.ncbi.nlm.nih.gov/22659177

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Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery

Autor: Francesca Ercole, Pascal D. Odermatt, Kim L. Wark, Brigitte Städler, Elli Saveriades, Frank Caruso, Rona Chandrawati, Kerry Breheney, Almar Postma, Leticia Hosta-Rigau

Publikováno v: Hosta-Rigau, L, Chandrawati, R, Saveriades, E, Odermatt, P D, Postma, A, Ercole, F, Breheney, K, Wark, K L, Stadler, B & Caruso, F 2010, ' Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery ', Biomacromolecules, vol. 11, pp. 3548-3555 .

We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to nonco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db6a88ae18fe195e4d64e4e1b232556
https://pure.au.dk/portal/da/publications/noncovalent-liposome-linkage-and-miniaturization-of-capsosomes-for-drug-delivery(4d7c7ec0-f962-11df-a891-000ea68e967b).html

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Cytotoxicity and internalization of polymer hydrogel capsules by mammalian cells

Autor: Elvira Tjipto, Remy Robert, Alexander N. Zelikin, Kerry Breheney, Kim L. Wark

Publikováno v: Biomacromolecules. 11(8)

Polymer hydrogel capsules comprised of poly(methacrylic acid) chains and cross-linked via disulfide linkages were investigated for their cytotoxicity and mechanism of internalization in a variety of mammalian cells. The capsules were internalized by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd53f7ddd59131e9caf56778b91d8e94
https://pubmed.ncbi.nlm.nih.gov/20614935

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A microreactor with thousands of subcompartments: enzyme-loaded liposomes within polymer capsules

Autor: Frank Caruso, Kerry Breheney, Rona Chandrawati, Andrew D. Price, Siow-Feng Chong, Luke A. Connal, Almar Postma, Alexander N. Zelikin, Brigitte Städler

Publikováno v: Angewandte Chemie (International ed. in English). 48(24)

Fully loaded: Noncovalent anchoring of liposomes into polymer multilayered films with cholesterol-modified polymers allows the preparation of capsosomes-liposome-compartmentalized polymer capsules (see picture). A quantitative enzymatic reaction conf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426b537898c5d5a72c1147b20f9e7cc2
https://pubmed.ncbi.nlm.nih.gov/19418505

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