Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Kerry A. Chester"'
Autor:
Alessia Floerchinger, Jessica E. Klein, Maximiliane S. C. Finkbeiner, Theresa E. Schäfer, Gwendolin Fuchs, Johannes Doerner, Hubert Zirngibl, Maximilian Ackermann, Hans M. Kvasnicka, Kerry A. Chester, Dirk Jäger, Claudia R. Ball, Guy Ungerechts, Christine E. Engeland
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-15 (2023)
Abstract Treatment with oncolytic measles vaccines (MV) elicits activation of immune cells, including natural killer (NK) cells. However, we found that MV-activated NK cells show only modest direct cytotoxic activity against tumor cells. To specifica
Externí odkaz:
https://doaj.org/article/631734c3778d40469ec6d6b74ebecfb0
Autor:
Mathieu Ferrari, Claire Roddie, Shimobi Onuoha, Martin Pule, Matteo Righi, Farhaan Parekh, Jenny Yeung, Kerry A. Chester, Patrycja Wawrzyniecka, Biao Ma, Leila Mekkaoui, Fatemeh V. Dastjerdi, Francesco Nannini, Yuchen Bai
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Antibody phage display is a powerful platform for discovery of clinically applicable high affinity monoclonal antibodies against a broad range of targets. Libraries generated from immunized animals offer the advantage of in vivo affinity-maturation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7f85767707c4e0d5c3212ea9b099b4
https://doi.org/10.1038/s41598-020-76069-3
https://doi.org/10.1038/s41598-020-76069-3
Autor:
David Howard, Haitao Wang, Kelvin Siu Hoong Loke, Marc L Ooft, Martin Forster, Teresa Marafioti, Bing Tan, Yim Ling Yip, Christopher D. Steele, Liesa Marie Schreiber, I. Indrawati, Sai Wah Tsao, Jozsef Dudas, Ruilian Xu, Martin Philpott, Wayne Pearce, Quynh-Thu Le, Susanne Delecluse, Shuting Han, Feng Wu, Herbert Riechelmann, Nischalan Pillay, Cillian T. Forde, Guido Wollmann, Zhiqiang Cheng, Johannes Haybaeck, Rajeev Gupta, Jacklyn Liu, Volker Hans Schartinger, Joshua K. Tay, Wen Long Nei, Simon Wan, Mohd Afiq Mohd Slim, Wan He, Kerry A. Chester, Daniele Morelli, Joe Yeong, Susanne Sprung, Udo Oppermann, Matt Lechner, Stefan M. Willems, Amit Jain, Christopher G. Bell, Kwok Wai Lo, Yuk Yu Chan, Gary Royle, Henri Jacques Delecluse, Renske Fles, Graham Wells, Christian Uprimny, Liam Sutton, Chi Man Tsang, Philippe Busson, Christodoulos P. Pipinikas, Amrita Jay, Tim Meyer, Peter H. Hwang, Hongtao Jin, Julia Koller, Tim R. Fenton, Valerie J. Lund, Ka Fai To, Annika Krapp, Camelia Herdini, Liam Masterson, Christina Thirlwell, Melvin L.K. Chua, Grace Tin-Yun Chung, Robert B. West, Bart Vanhaesebroeck, Reshma Nibhani, Sagung Rai Indrasari
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12, ⟨10.1038/s41467-020-20308-8⟩
Nature Communications, 12(1):117. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Nature Publishing Group, 2021, 12, ⟨10.1038/s41467-020-20308-8⟩
Nature Communications, 12(1):117. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df23d13e881be6d36d9f87a03605c407
https://pubmed.ncbi.nlm.nih.gov/33402692
https://pubmed.ncbi.nlm.nih.gov/33402692
Autor:
Francis Vaz, Cillian T. Forde, Paul O'Flynn, Amrita Jay, Kerry A. Chester, Ankur Chakravarthy, Vonn Walter, Paul M. Weinberger, Nicholas Kalavrezos, Terry Jones, Matt Lechner, Richard A. McIndoe, D. Neil Hayes, Liam Masterson, Martin Forster, Tim R. Fenton, Andrew Feber
Publikováno v:
Oral Oncology. 83:32-37
Objectives\ud p16INK4A (p16) is the most widely used clinical biomarker for Human Papillomavirus (HPV) in head and neck squamous cell cancer (HNSCC). HPV is a favourable prognostic marker in HNSCC and is used for patient stratification. While p16 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fc3b4c1c28162837e084e326b55b8e
https://doi.org/10.1016/j.oraloncology.2018.06.006
https://doi.org/10.1016/j.oraloncology.2018.06.006
Publikováno v:
Current Opinion in Chemical Engineering. 19:153-162
Antibody therapy for cancer has potential to combine specific targeting with a range of effector mechanisms to produce potent anti-tumor responses. Antibody-based treatments are growing in success for adult cancers but have shown limited efficacy for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47bfc42541562aa39274dd397a83285e
https://doi.org/10.1016/j.coche.2018.01.005
https://doi.org/10.1016/j.coche.2018.01.005
Autor:
Manon Pillai, Andrea J. Byatte, Deborah J. Burt, Susan Wan, Fiona C Thistlethwaite, Robert E. Hawkins, Stephen Nabarro, Kerry A. Chester, David E. Gilham, Sarah E. R. Halford, Eric Austin, Dominic G. Rothwell, Natalia Kirillova, Ryan D. Guest, Surinder K. Sharma, Nigel B. Westwood, Juan W. Valle
Publikováno v:
Cancer Immunology, Immunotherapy
Thistlethwaite, F, Gilham, D, Guest, R, Rothwell, D, Pillai, M, Burt, D, Byatte, A J, Kirillova, N, Valle, J, Sharma, S K, Chester, K A, Westwood, N, Halford, S ER, Nabarro, S, Wan, S, Austin, E & Hawkins, R E 2017, ' The clinical efficacy of first generation carcinoembryonic antigen (CEACAM5) specific CAR T cells is limited by poor persistence and transient pre-conditioning dependent respiratory toxicity ', Cancer Immunology, Immunotherapy . https://doi.org/10.1007/s00262-017-2034-7
Thistlethwaite, F, Gilham, D, Guest, R, Rothwell, D, Pillai, M, Burt, D, Byatte, A J, Kirillova, N, Valle, J, Sharma, S K, Chester, K A, Westwood, N, Halford, S ER, Nabarro, S, Wan, S, Austin, E & Hawkins, R E 2017, ' The clinical efficacy of first generation carcinoembryonic antigen (CEACAM5) specific CAR T cells is limited by poor persistence and transient pre-conditioning dependent respiratory toxicity ', Cancer Immunology, Immunotherapy . https://doi.org/10.1007/s00262-017-2034-7
The primary aim of this clinical trial was to determine the feasibility of delivering first-generation CAR T cell therapy to patients with advanced, CEACAM5+ malignancy. Secondary aims were to assess clinical efficacy, immune effector function and op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7223f806af597e46891f1f0d5798376f
https://doi.org/10.1007/s00262-017-2034-7
https://doi.org/10.1007/s00262-017-2034-7
We have cloned and characterized a novel fusion protein (Sm3E-TNF), consisting of the monoclonal antibody Sm3E in single-chain Fv fragment format, fused to murine tumor necrosis factor. The protein, which was expressed in mammalian cells and purified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931b13b07fd3477405ba6770aeb8b1fa
https://doi.org/10.1101/698563
https://doi.org/10.1101/698563
Autor:
Amit C. Nathwani, Alessandro Barbarulo, Toby Batten, Fiona Germaschewski, Kerry A. Chester, Kathryn H. Brown, Parag Jasani, David Granger, Sarah Cook, Peter C. Phillips, Satyen H. Gohil, Kieran O'Donovan, Annalisa Baccaro, Vincent Muczynski
Publikováno v:
Journal of Clinical Oncology. 39:7549-7549
7549 Background: Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1) is a type I transmembrane protein is highly expressed on an array of haematological and solid tumours. NVG-111 is a humanised, tandem scFv ROR1xCD3 bispecific antibody previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87f8253d3ab84d36a6aa4a3ccb10578e
https://doi.org/10.1200/jco.2021.39.15_suppl.7549
https://doi.org/10.1200/jco.2021.39.15_suppl.7549
Autor:
Quentin A. Pankhurst, May Zaw Thin, Matthew Ellis, Fang-Yu Lin, Sergio A. Quezada, Giulia Agliardi, Clare Jones, Mark F. Lythgoe, Kerry A. Chester, Maxim Shevtsov, R. Barbara Pedley, Maha R. A. Abdollah, Thomas Carter, Paul Mulholland, Cordula Gruettner, Paul Southern, Angela Richard-Londt, Tammy L. Kalber, Mathew Robson, V. A. Ryzhov, Rafael Torres Martin de Rosales, Sebastian Brandner
Publikováno v:
Small. 17:2005241
Magnetic hyperthermia (MH) harnesses the heat-releasing properties of superparamagnetic iron oxide nanoparticles (SPIONs) and has potential to stimulate immune activation in the tumor microenvironment whilst sparing surrounding normal tissues. To ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d8f96c7bab52b48ecd37962801fd50
https://doi.org/10.1002/smll.202005241
https://doi.org/10.1002/smll.202005241
Publikováno v:
Clinical Oncology. 28(10):622-626
The median survival in glioblastoma is just over a year, with no standard second-line therapy. Ipilimumab is an immune checkpoint inhibitor that activates the anti-tumour immune response by cytotoxic T-lymphocyte antigen-4 blockade. There is signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5657fe09971ba7a5e770559c2a09e2