Výsledky vyhledávání - "Kerry A. Breheney"

scFv multimers of the anti-neuraminidase antibody NC10: length of the linker between VH and VL domains dictates precisely the transition between diabodies and triabodies

Autor: Alexander A. Kortt, Lynne J. Lawrence, Peter J. Hudson, Kerry A. Breheney, Airlie J. McCoy, John Leslie Atwell

Publikováno v: Protein Engineering, Design and Selection. 12:597-604

Single-chain Fv antibody fragments (scFvs) incorporate a polypeptide linker to tether the VH and VL domains together. An scFv molecule with a linker 5-12 residues long cannot fold into a functional Fv domain and instead associates with a second scFv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0f3852f9ec33b609c741513f3aa852
https://doi.org/10.1093/protein/12.7.597

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