Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Kerry A Pierce"'
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
Autor:
Wayne Mitchell, Ludger JE Goeminne, Alexander Tyshkovskiy, Sirui Zhang, Julie Y Chen, Joao A Paulo, Kerry A Pierce, Angelina H Choy, Clary B Clish, Steven P Gygi, Vadim N Gladyshev
Publikováno v:
eLife, Vol 12 (2024)
Partial reprogramming by cyclic short-term expression of Yamanaka factors holds promise for shifting cells to younger states and consequently delaying the onset of many diseases of aging. However, the delivery of transgenes and potential risk of tera
Externí odkaz:
https://doaj.org/article/c3386c2215b54367bf7d646d779bdae7
Autor:
Andrei S Avanesov, Siming Ma, Kerry A Pierce, Sun Hee Yim, Byung Cheon Lee, Clary B Clish, Vadim N Gladyshev
Publikováno v:
eLife, Vol 3 (2014)
Aging is thought to be associated with increased molecular damage, but representative markers vary across conditions and organisms, making it difficult to assess properties of cumulative damage throughout lifespan. We used nontargeted metabolite prof
Externí odkaz:
https://doaj.org/article/e7ef3eed247c4913a85718b90e6c1b0a
Autor:
Wen Zhou, Petra Simic, Iris Y. Zhou, Peter Caravan, Xavier Vela Parada, Donghai Wen, Onica L. Washington, Maria Shvedova, Kerry A. Pierce, Clary B. Clish, Michael Mannstadt, Tatsuya Kobayashi, Marc N. Wein, Harald Jüppner, Eugene P. Rhee
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
How phosphate levels are detected in mammals is unknown. The bone-derived hormone fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney phosphate reabsorption and 1,25(OH)2D production, but phosphate does not directly s
Externí odkaz:
https://doaj.org/article/e89541dfb86a4e3cba30439d498ee8eb
Autor:
Emilie Heckel, Gael Cagnone, Tapan Agnihotri, Bertan Cakir, Ashim Das, Jin Sung Kim, Nicholas Kim, Geneviève Lavoie, Anu Situ, Sheetal Pundir, Ye Sun, Florian Wünnemann, Kerry A. Pierce, Courtney Dennis, Grant A. Mitchell, Sylvain Chemtob, Flavio A. Rezende, Gregor Andelfinger, Clary B. Clish, Philippe P. Roux, Przemyslaw Sapieha, Lois E.H. Smith, Jean-Sébastien Joyal
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Dyslipidemia and autophagy have been implicated in the pathogenesis of blinding neovascular age-related macular degeneration (NV-AMD). VLDL receptor (VLDLR), expressed in photoreceptors with a high metabolic rate, facilitates the uptake of triglyceri
Externí odkaz:
https://doaj.org/article/2daa7b5d47564630a41d65386cd0a30f
Autor:
Cristina Razquin, Miguel Ruiz-Canela, Clary B. Clish, Jun Li, Estefania Toledo, Courtney Dennis, Liming Liang, Albert Salas-Huetos, Kerry A. Pierce, Marta Guasch-Ferré, Dolores Corella, Emilio Ros, Ramon Estruch, Enrique Gómez-Gracia, Montse Fitó, Jose Lapetra, Dora Romaguera, Angel Alonso-Gómez, Lluis Serra-Majem, Jordi Salas-Salvadó, Frank B. Hu, Miguel A. Martínez-González
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-12 (2019)
Abstract Background The pandemic of cardiovascular disease (CVD) and type 2 diabetes (T2D) requires the identification of new predictor biomarkers. Biomarkers potentially modifiable with lifestyle changes deserve a special interest. Our aims were to
Externí odkaz:
https://doaj.org/article/867a62a89e52445e93ea1a90def82e6d
Autor:
Jon M. Madison, Karen Duong, Ellen F. Vieux, Namrata D. Udeshi, Sumaiya Iqbal, Elise Requadt, Shaunt Fereshetian, Michael C. Lewis, Antonio S. Gomes, Kerry A. Pierce, Randall J. Platt, Feng Zhang, Arthur J. Campbell, Dennis Lal, Florence F. Wagner, Clary B. Clish, Steven A. Carr, Morgan Sheng, Edward M. Scolnick, Jeffrey R. Cottrell
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101935- (2021)
Summary: Genetic variation of the 16p11.2 deletion locus containing the KCTD13 gene and of CUL3 is linked with autism. This genetic connection suggested that substrates of a CUL3-KCTD13 ubiquitin ligase may be involved in disease pathogenesis. Compar
Externí odkaz:
https://doaj.org/article/02815da01a7f40da86fd1e72b7901ade
Autor:
Daniel F. Rojas-Tapias, Eric M. Brown, Emily R. Temple, Michelle A. Onyekaba, Ahmed M. T. Mohamed, Kellyanne Duncan, Melanie Schirmer, Rebecca L. Walker, Toufic Mayassi, Kerry A. Pierce, Julián Ávila-Pacheco, Clary B. Clish, Hera Vlamakis, Ramnik J. Xavier
Publikováno v:
Nat Microbiol
Colonization of the intestine by oral microbes has been linked to multiple diseases such as inflammatory bowel disease and colon cancer, yet mechanisms allowing expansion in this niche remain largely unknown. Veillonella parvula, an asaccharolytic, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96365e93bbd93c708077b666c1bcf26
https://doi.org/10.1038/s41564-022-01224-7
https://doi.org/10.1038/s41564-022-01224-7
Autor:
Eugene P. Rhee, Qiong Yang, Bing Yu, Xuan Liu, Susan Cheng, Amy Deik, Kerry A. Pierce, Kevin Bullock, Jennifer E. Ho, Daniel Levy, Jose C. Florez, Sek Kathiresan, Martin G. Larson, Ramachandran S. Vasan, Clary B. Clish, Thomas J. Wang, Eric Boerwinkle, Christopher J. O’Donnell, Robert E. Gerszten
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Several GWAS have identified many common variants associated with blood metabolites. Here, the authors use an exome array to identify low frequency, potentially functional variants that impact human metabolism.
Externí odkaz:
https://doaj.org/article/2656afb9eb474ee0a0e2803a09511c00
Autor:
Brandon M. Cuevas, Katerina Politi, Bomiao Hu, Charles P. Fulco, Pratiksha I. Thakore, Michael S. Cuoco, Jan-Christian Hütter, William Colgan, Aaron N. Hata, Sara A. Hurvitz, Kerry A. Pierce, Amy Deik, Liat Amir-Zilberstein, Marcin Tabaka, Joan S. Brugge, Dennis J. Slamon, Aviv Regev, Galit Lahav, Michael Tsabar, Clary B. Clish, Yaara Oren, Elma Zaganjor, Heidie Frisco Cabanos
Publikováno v:
Nature, vol 596, iss 7873
Nature
Nature
Non-genetic mechanisms have recently emerged as important drivers of cancer therapy failure1, where some cancer cells can enter a reversible drug-tolerant persister state in response to treatment2. Although most cancer persisters remain arrested in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb44f4b5bdaa7e5d903499a8bbdcfcf
https://doi.org/10.1038/s41586-021-03796-6
https://doi.org/10.1038/s41586-021-03796-6
Autor:
Fernando Arós, Jun Li, Frank B. Hu, Kerry A. Pierce, Clary B. Clish, Miguel Ruiz-Canela, Christopher Papandreou, Liming Liang, Miguel Ángel Martínez-González, Mònica Bulló, Dolores Corella, Cristina Razquin, Lluis Serra-Majem, Estefanía Toledo, Marta Guasch-Ferré, Jesús García-Gavilán, Ramon Estruch, Jordi Salas-Salvadó, Montserrat Fitó, Emilio Ros, Chih-Hao Lee
Publikováno v:
Metabolism
Background Tricarboxylic acid (TCA) cycle deregulation may predispose to cardiovascular diseases, but the role of TCA cycle-related metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unexplored. This study sough
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87da8b1989b9c4d89e6ece5fd60f1019
https://europepmc.org/articles/PMC9206868/
https://europepmc.org/articles/PMC9206868/
