Zobrazeno 1 - 10 of 137 pro vyhledávání: '"Kerry, Fenwick"'
1
Akademický článek
Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
Autor: Katharina von Loga, Andrew Woolston, Marco Punta, Louise J. Barber, Beatrice Griffiths, Maria Semiannikova, Georgia Spain, Benjamin Challoner, Kerry Fenwick, Ronald Simon, Andreas Marx, Guido Sauter, Stefano Lise, Nik Matthews, Marco Gerlinger
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Tumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.
Externí odkaz: https://doaj.org/article/f202e0a95a5045ca81301d8ebb687ecf
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2
Akademický článek
Next Generation Sequencing Assay for Detection of Circulating HPV DNA (cHPV-DNA) in Patients Undergoing Radical (Chemo)Radiotherapy in Anal Squamous Cell Carcinoma (ASCC)
Autor: Jen Y. Lee, Rosalind J. Cutts, Ingrid White, Yolanda Augustin, Isaac Garcia-Murillas, Kerry Fenwick, Nik Matthews, Nicholas C. Turner, Kevin Harrington, Duncan C. Gilbert, Shreerang Bhide
Publikováno v: Frontiers in Oncology, Vol 10 (2020)
Background: Following chemo-radiotherapy (CRT) for human papilloma virus positive (HPV+) anal squamous cell carcinoma (ASCC), detection of residual/recurrent disease is challenging. Patients frequently undergo unnecessary repeated biopsies for abnorm
Externí odkaz: https://doaj.org/article/237f71c14eef4ff8bb19bc7f8c8b1eea
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3
Akademický článek
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
Autor: Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I. Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N. Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M. Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J. Lord
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells, su
Externí odkaz: https://doaj.org/article/1eb977c74fb546b0a7321e49be5d0643
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4
Akademický článek
Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
Autor: Joseph S. Baxter, Olivia C. Leavy, Nicola H. Dryden, Sarah Maguire, Nichola Johnson, Vita Fedele, Nikiana Simigdala, Lesley-Ann Martin, Simon Andrews, Steven W. Wingett, Ioannis Assiotis, Kerry Fenwick, Ritika Chauhan, Alistair G. Rust, Nick Orr, Frank Dudbridge, Syed Haider, Olivia Fletcher
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Risk loci for breast cancer have been identified by genome-wide association studies. Here, the authors use Capture Hi-C to identify 110 putative target genes at 33 loci and assessed associations of gene expression, SNP genotype, and survival, providi
Externí odkaz: https://doaj.org/article/04f38edcab7d46faa2e61354e4ef0a11
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