Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kerrin Hansen"'
Autor:
Iga Jakobowska, Frank Becker, Stefano Minguzzi, Kerrin Hansen, Björn Henke, Nathan Hugo Epalle, Eric Beitz, Stefan Hannus
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 757 (2021)
Blocking lactate export in the parasitic protozoan Plasmodium falciparum is a novel strategy to combat malaria. We discovered small drug-like molecules that inhibit the sole plasmodial lactate transporter, PfFNT, and kill parasites in culture. The pe
Externí odkaz:
https://doaj.org/article/5aa87a5ca06b4543a7a20fec80386a82
Autor:
Jeyaprakashnarayanan Seenisamy, Frank Becker, Djordje Musil, Jörg Bomke, Jakub Gunera, Uwe Eckert, Timo Heinrich, Felix Rohdich, Kerrin Hansen, Beatrix Blume, Christian Siegl, Frank Zenke, Jens Pfalzgraf, Dieter Spuck, Ansgar Wegener, Birgitta Leuthner, Melanie Dietz, Manja Friese-Hamim
Publikováno v:
Journal of Medicinal Chemistry. 62:11119-11134
The recently disclosed next generation of reversible, selective, and potent MetAP-2 inhibitors introduced a cyclic tartronic diamide scaffold. However, the lead compound 1a suffered from enterohepatic circulation, preventing further development. Neve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::539fb7d602f3d1bbfe1d4a86e7331eb7
https://doi.org/10.1021/acs.jmedchem.9b01070
https://doi.org/10.1021/acs.jmedchem.9b01070
Autor:
Margaret S. Lee, Sharon Shacham, Marsha Crochiere, Frank Becker, Erkan Baloglu, Michael Kauffman, Kerrin Hansen, Stefan Hannus, Yosef Landesman
Publikováno v:
Oncotarget
XPO1 (exportin 1) is the main nuclear export protein with over 200 different protein cargos. XPO1 is overexpressed in tumor cells and high levels are correlated with poor prognosis. Selective Inhibitor of Nuclear Export (SINE) compounds block nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a20c36cb8ee7c00a27663ab673a5806
https://doi.org/10.18632/oncotarget.22801
https://doi.org/10.18632/oncotarget.22801
Autor:
Timo, Heinrich, Jeyaprakashnarayanan, Seenisamy, Frank, Becker, Beatrix, Blume, Jörg, Bomke, Melanie, Dietz, Uwe, Eckert, Manja, Friese-Hamim, Jakub, Gunera, Kerrin, Hansen, Birgitta, Leuthner, Djordje, Musil, Jens, Pfalzgraf, Felix, Rohdich, Christian, Siegl, Dieter, Spuck, Ansgar, Wegener, Frank T, Zenke
Publikováno v:
Journal of medicinal chemistry. 62(24)
The recently disclosed next generation of reversible, selective, and potent MetAP-2 inhibitors introduced a cyclic tartronic diamide scaffold. However, the lead compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b4dcbfeb991a35c29e879c5251cd665
https://pubmed.ncbi.nlm.nih.gov/31725285
https://pubmed.ncbi.nlm.nih.gov/31725285
Autor:
Stefan Hannus, Roland Brock, Heike Glauner, Kerrin Hansen, Frank Becker, Yi-Da Chung, Ben Steemers, Ivo R. Ruttekolk
Publikováno v:
British Journal of Pharmacology. 160:958-970
Background and purpose: In vitro assays that determine activities of drug candidates with isolated targets have only limited predictive value for activities in cellular assays. Poor membrane permeability and off-target binding are major reasons for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5831e9d9db5726809f168caa404ce0
https://doi.org/10.1111/j.1476-5381.2010.00732.x
https://doi.org/10.1111/j.1476-5381.2010.00732.x
Publikováno v:
Molecular Cancer Therapeutics. 17:LB-B09
The quantification of Target Occupancy (TO) in cells after application of an inhibitor is an important parameter to correlate the biochemical features of a drug with its in vivo efficacy. Experimental evidence of TO is a robust support of the target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65dbc488d494a3b909d7a3f52a95b4e1
https://doi.org/10.1158/1535-7163.targ-17-lb-b09
https://doi.org/10.1158/1535-7163.targ-17-lb-b09
Publikováno v:
Molecular Immunology, 46, 3269-77
Molecular Immunology, 46, 16, pp. 3269-77
Molecular Immunology, 46, 16, pp. 3269-77
Contains fulltext : 81245.pdf (Publisher’s version ) (Closed access) Antibodies of the IgG4 subclass, directed against cell surface antigens have received attention as therapeutic molecules due to their poor induction of the complement system. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f516c7f235dd9b536097516fd594a4
https://doi.org/10.1016/j.molimm.2009.07.031
https://doi.org/10.1016/j.molimm.2009.07.031
Autor:
Frank Becker, Yosef Landesman, Kerrin Hansen, Erkan Baloglu, Marsha Crochiere, Stefan Hannus, Michael Kauffman
Publikováno v:
Blood. 128:1563-1563
Introduction: Selective Inhibitor of Nuclear Export (SINE) compounds are a new class of oral anti-cancers drugs that block nuclear export by inhibiting the exportin XPO1 (also known as CRM1). The most advanced compounds in this class are selinexor an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b20eec64bf6ae9c25a9ab03ff32252a
https://doi.org/10.1182/blood.v128.22.1563.1563
https://doi.org/10.1182/blood.v128.22.1563.1563
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Autor:
Anna, Iervolin, Tim, Lange, Kerrin, Hansen, Florian, Siegerist, Elke, Hammer, Uwe, Völker, Karsten, Schulze, Giovambattista, Capasso, Karlhans, Endlich, Endlich, Nicole
Publikováno v:
Nephrology Dialysis Transplantation; 2019 Supplement, Vol. 34, pN.PAG-N.PAG, 1p