Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kerri X, Yan"'
Autor:
James Dru, Diana V. Selverian, M.L Constanzer, Tuli Ahmed, Kevin J. Petty, Anup K. Majumdar, Howard E. Greenberg, Jacqueline B. McCrea, Kerri X. Yan, Glen S. Frick, Suna Barlas, Walter K. Kraft
Publikováno v:
The Journal of Clinical Pharmacology. 47:744-750
Oral aprepitant 125 mg, an antiemetic and a moderate inhibitor of the metabolism of oral midazolam, was assessed for interaction with intravenous midazolam in 12 subjects randomized to intravenous midazolam 2 mg +/- oral aprepitant 125 mg. The hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a439d4c297565d590aa34167dd5ed7
https://doi.org/10.1177/0091270007300807
https://doi.org/10.1177/0091270007300807
Autor:
Marina De Smet, Haiyuan Zhu, Zissi Matthijs, Katelijn Decochez, Hengchang Song, Amy O. Johnson-Levonas, Hannah O Maynor, Ronda K. Rippley, Jutta Miller, Kerri X. Yan, John A. Wagner, Bart Keymeulen, Keith Gottesdiener, Michael J. Davies, Kerry Riffel, Wesley Tanaka
Publikováno v:
Drugs in R & D. 7:99-110
Background: The objective of these studies was to evaluate the pharmacokinetics and pharmacodynamics of MK-0767, a prototypical dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist, following administration of single and multiple oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::953c7f84811c4be8d08b56ccde70484e
https://doi.org/10.2165/00126839-200607020-00004
https://doi.org/10.2165/00126839-200607020-00004
Publikováno v:
Journal of Chromatography B. 814:29-36
Turbulent flow chromatograph (TFC) is a technique for the direct and efficient analysis of drugs and metabolites in biological matrices. We report here TFC on-line with an HPLC-MS/MS assay for the determination of 5-[2,4-dioxothiazolidin-5-yl)methyl]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabbb5d082eacf7b244083fcaa91034d
https://doi.org/10.1016/j.jchromb.2004.09.033
https://doi.org/10.1016/j.jchromb.2004.09.033
Human pharmacokinetics and interconversion of enantiomers of MK-0767, a dual PPARalpha/gamma agonist
Autor:
Howard E. Greenberg, Natalie D. Matthews, Ronda K. Rippley, Kerri X. Yan, Gary A. Herman, John A. Wagner
Publikováno v:
Journal of clinical pharmacology. 47(3)
MK-0767, a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, has been studied as a potential treatment of type 2 diabetes and dyslipidemia. The pharmacokinetics and interconversion of (+)-(R)-MK-0767 and (-)-(S)-MK-0767 were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d4ea939ae6b44e70725027322cca02
https://pubmed.ncbi.nlm.nih.gov/17322144
https://pubmed.ncbi.nlm.nih.gov/17322144
Autor:
Katelijn, Decochez, Ronda K, Rippley, Jutta L, Miller, Marina, De Smet, Kerri X, Yan, Zissi, Matthijs, Kerry A, Riffel, Hengchang, Song, Haiyuan, Zhu, Hannah O, Maynor, Wesley, Tanaka, Amy O, Johnson-Levonas, Michael J, Davies, Keith M, Gottesdiener, Bart, Keymeulen, John A, Wagner
Publikováno v:
Drugs in RD. 7(2)
The objective of these studies was to evaluate the pharmacokinetics and pharmacodynamics of MK-0767, a prototypical dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, following administration of single and multiple oral doses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c159a5b96925e7d58739f456172eba8e
https://pubmed.ncbi.nlm.nih.gov/16542056
https://pubmed.ncbi.nlm.nih.gov/16542056
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 813(1-2)
A sensitive and selective analytical method for the enantioselective determination of MK-0767, a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, in human plasma has been developed and validated. The chromatography is based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69d52164d6c137084db99b371d38b1b
https://pubmed.ncbi.nlm.nih.gov/15556521
https://pubmed.ncbi.nlm.nih.gov/15556521
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 27(5)
A sensitive, specific, and robust liquid chromatography (LC)/mass spectrometry (MS)/MS method has been developed and validated for a novel M3 muscarinic receptor antagonist (I) and its active 5-OH metabolite (II) in human plasma. The assay involves a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e7b73041fa918ba0a484903d15839a
https://pubmed.ncbi.nlm.nih.gov/11814711
https://pubmed.ncbi.nlm.nih.gov/11814711
Autor:
Ronda K. Rippley, Jutta Miller, Keith Gottesdiener, Kerri X. Yan, C. Thach, John A. Wagner, Hengchang Song, David Hreniuk, K. C. Lasseter
Publikováno v:
Clinical Pharmacology & Therapeutics. 75:P58
This analysis investigated the effect of age and gender on the pharmacokinetics (PK) of MK-0767, a dual PPARα/γ agonist, in healthy men and women. Sixteen healthy elderly men and women received single doses of 10 mg MK-0767 (n=12; 6 males, 6 female
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39e52932998a63d717de7b7d0193aa27
https://doi.org/10.1016/j.clpt.2003.11.219
https://doi.org/10.1016/j.clpt.2003.11.219