Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kerri Lipinski"'
Autor:
Pooja P Pungaliya, Yuchen Bai, Kerri Lipinski, Vasanti S Anand, Saurabh Sen, Eugene L Brown, Brian Bates, Peter H Reinhart, Andrew B West, Warren D Hirst, Steven P Braithwaite
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13672 (2010)
Mutations in LRRK2 (leucine-rich repeat kinase 2) have been identified as major genetic determinants of Parkinson's disease (PD). The most prevalent mutation, G2019S, increases LRRK2's kinase activity, therefore understanding the sites and substrates
Externí odkaz:
https://doaj.org/article/7795cb510d11410bb3354211ec86ecfc
Autor:
Jing Zhou, Suresh B. Singh, Colin M. Tice, Rebecca Van Orden, Guozhou Chen, Geeta Kandpal, Shi Meng, Cheng-Guo Dong, Yuri Bukhtiyarov, Paul B. Noto, Stephen D. Lotesta, Wei Zhao, Lamont Howard, Katerina Leftheris, Andrew P. Marcus, Kristi Fan, Andrew W. Hardy, Deepak S. Lala, Paula Krosky, Linghang Zhuang, Brian M. McKeever, Gerard McGeehan, Kerri Lipinski, Ya-Jun Zheng, Joan Guo, Yi Zhao, Richard Gregg, David A. Claremon, Zhongren Wu
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(20)
Liver X receptor (LXR) agonists have been reported to lower brain amyloid beta (Aβ) and thus to have potential for the treatment of Alzheimer's disease. Structure and property based design led to the discovery of a series of orally bioavailable, bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dfa607065920889aae5780297b0a05
https://pubmed.ncbi.nlm.nih.gov/27599745
https://pubmed.ncbi.nlm.nih.gov/27599745
Autor:
Deepak S. Lala, Paula Krosky, Kerri Lipinski, Colin M. Tice, Ya-Jun Zheng, Lamont Howard, Richard Gregg, Paul B. Noto, Yi Zhao, Kristi Fan, David A. Claremon, Zhongren Wu, Andrew W. Hardy, Rebecca Van Orden, Jing Zhou, Gerard McGeehan, Joan Guo, Cheng-Guo Dong, Stephen D. Lotesta, Geeta Kandpal, Jun Shimada, Zhijie Liu, Katerina Leftheris, Shi Meng, Suresh B. Singh, Guozhou Chen, Linghang Zhuang, Brian M. McKeever, Peter Lindblom, Yuri Bukhtiyarov, Wei Zhao
Publikováno v:
Journal of medicinal chemistry. 59(7)
This article describes the application of Contour to the design and discovery of a novel, potent, orally efficacious liver X receptor β (LXRβ) agonist (17). Contour technology is a structure-based drug design platform that generates molecules using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72847825e5e910bcb4d0f464f422727e
https://pubmed.ncbi.nlm.nih.gov/26990539
https://pubmed.ncbi.nlm.nih.gov/26990539
Autor:
Arlene Joan Dietrich, Warren D. Hirst, Paul Jeffrey Dollings, Afshin Ghavami, Kerri Lipinski, Andrew F. Donnell, John A. Butera
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2163-2167
Substituted pyridazino[4,5-b]indolizines were identified as potent and selective PDE4B inhibitors. We describe the structure-activity relationships generated around an HTS hit that led to a series of compounds with low nanomolar affinity for PDE4B an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba711653bda7425ea68bc3a2b065dd3c
https://doi.org/10.1016/j.bmcl.2010.02.044
https://doi.org/10.1016/j.bmcl.2010.02.044
Autor:
Kerri Lipinski, Pooja Pungaliya, Vasanti S. Anand, Warren D. Hirst, Brian Bates, Peter H. Reinhart, Sercan Sen, Eugene L. Brown, Yuchen Bai, Steven P. Braithwaite, Andrew B. West
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 10, p e13672 (2010)
PLoS ONE, Vol 5, Iss 10, p e13672 (2010)
Mutations in LRRK2 (leucine-rich repeat kinase 2) have been identified as major genetic determinants of Parkinson's disease (PD). The most prevalent mutation, G2019S, increases LRRK2's kinase activity, therefore understanding the sites and substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fa6747a4bc89de8c0554b0507b8cf4
http://europepmc.org/articles/PMC2965117
http://europepmc.org/articles/PMC2965117
Autor:
Joshua D Berkowitz, Boyd L. Harrison, Robert Martone, Hua Zhou, Micheal Chlenov, Yun Hu, Peimin Lu, Koi Michele Morris, June Sonnenberg-Reines, S. Aschmies, Joan E. Sabalski, Kerri Lipinski, George Diamantidis, Kevin Atchison, Thomas J. Caggiano, Shaiu-Ching Sun, Zheng Xu, Jun Pu, Anthony F. Kreft, Dave R. Riddell, Yiqun Wang, Lynn Resnick, Mei Jin, Donna M. Huryn, Erik Wagner, J. Steven Jacobsen
Publikováno v:
Bioorganicmedicinal chemistry. 17(13)
gamma-Secretase inhibitors have been shown to reduce the production of beta-amyloid, a component of the plaques that are found in brains of patients with Alzheimer's disease. A novel series of heterocyclic sulfonamide gamma-secretase inhibitors that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb35335c5e137415c463df8839ade10
https://pubmed.ncbi.nlm.nih.gov/19443228
https://pubmed.ncbi.nlm.nih.gov/19443228
Autor:
Steven M. Riddle, Eugene L. Brown, Vasanti S. Anand, Richard Somberg, Kerry Kelleher, Pooja Pungaliya, Wayne Stochaj, Warren D. Hirst, Peter H. Reinhart, Steven P. Braithwaite, Weili Duan, Kerri Lipinski, Laurie J. Reichling
Publikováno v:
The FEBS journal. 276(2)
Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the leading cause of autosomal dominant Parkinson's disease, with age of onset and symptoms identical to those of idiopathic forms of the disorder. Several of these pathogenic mutations are t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5050abbf28183f941c26ca55054721
https://pubmed.ncbi.nlm.nih.gov/19076219
https://pubmed.ncbi.nlm.nih.gov/19076219
Autor:
Magid Abou-Gharbia, Anthony Kreft, Peter H. Reinhart, J. Steven Jacobsen, Kevin Atchison, Robert Martone, Scott C. Mayer, Lynn Resnick, Ronald L. Magolda, Menelas N. Pangalos, Dennis M. Kubrak, Boyd L. Harrison, Kerri Lipinski, Ann Aulabaugh, Warren D. Hirst, Hua Zhou, Xinyi Huang, Michael K. May, Alex M. Porte, George Diamantidis
Publikováno v:
Alzheimer's & Dementia. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e136400868e4fe04c7474ae796b5ac4
https://doi.org/10.1016/j.jalz.2008.05.1414
https://doi.org/10.1016/j.jalz.2008.05.1414
Autor:
Gerard McGeehan, Yuri Bukhtiyarov, Yi Zhao, Shi Meng, Paul Noto, Jason Stadanlick, Barbara Kruk, Andrew Hardy, Kerri Lipinski, Geeta Kandpal, Bethany Algayer, Joan Guo, Rong Guo, Andrew Marcus, Stephen Lotesta, Chengguo Dong, Kristi Fan, Lanqi Jia, Jing Yuan, Yajun Zheng, Linghang Zhuang, Lawrence Dillard, David Claremon, Richard Gregg, Deepak Lala
Publikováno v:
The Journal of Immunology. 194:208.5-208.5|68.3
Increased production of the inflammatory cytokine IL-17A by Th17 cells is a driver of multiple autoimmune disorders, including psoriasis, ankylosing spondylitis (AS) and psoriatic arthritis (PsA). The nuclear receptor RORγt, IL-23 and TGFb are requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfb29b475ba7ba3df95dd43ac4b940cd
https://doi.org/10.4049/jimmunol.194.supp.208.5
https://doi.org/10.4049/jimmunol.194.supp.208.5
Autor:
Julia N. Heinrich, Frederick Lo, David Howland, Kerri Lipinski, Stephen Sturner, Ke-Yi Cheng, Seung Kwak, Jin Chen, Kelly Sullivan, Afshin Ghavami, Yijin She
Publikováno v:
Cellular signalling. 18(6)
Shc adapter proteins are thought to regulate cellular proliferation, differentiation and apoptosis by activating the SOS-Grb2-RAS-MAPK signaling cascade. Using the small hairpin RNA (shRNA) technique, we found that decreasing ShcA mRNA reduced the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97dde54c78089e7974245bfc4c8c4fb
https://pubmed.ncbi.nlm.nih.gov/16126371
https://pubmed.ncbi.nlm.nih.gov/16126371